Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T71390 Target Info
Target Name Steroid 5-alpha-reductase 2 (SRD5A2)
Synonyms Type 2 steroid 5alpha-reductase (5alpha-R); SRD5A2; SR type 2; 5-alpha reductase 2; 5 alpha-SR2
Target Type Successful Target
Gene Name SRD5A2
Biochemical Class CH-CH donor oxidoreductase
UniProt ID
S5A2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: [[(2~{R},3~{S},4~{R},5~{R})-5-[4-[(1~{S},3~{a}~{S},3~{b}~{S},5~{a}~{R},8~{S},9~{a}~{R},9~{b}~{S},11~{a}~{S})-1-(~{tert}-butylcarbamoyl)-9~{a},11~{a}-dimethyl-7-oxidanylidene-1,2,3,3~{a},3~{b},4,5,5~{a},6,8,9,9~{b},10,11-tetradecahydroindeno[5,4-f]quinolin-8-yl]-3-aminocarbonyl-4~{H}-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate Ligand Info
Structure Description Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride PDB:7BW1
Method X-ray diffraction Resolution 2.80 Å Mutation No [1]
PDB Sequence
CQQSPVLAGS
14
ATLVALGALA
24
LYVAKPSGYG
34
KHTEATRLPA
49
RAAWFLQELP
59

SFAVPAGILA
69
RQPLSLFGPP
79
GTVLLGLFCV
89
HYFHRTFVYS
99
LLNRGRPYPA
109

ILILRGTAFC
119
TGNGVLQGYY
129
LIYCAEYPDG
139
WYTDIRFSLG
149
VFLFILGMGI
159

NIHSDYILRQ
169
LRKPGEISYR
179
IPQGGLFTYV
189
SGANFLGEII
199
EWIGYALATW
209

SLPALAFAFF
219
SLCFLGLRAF
229
HHHRFYLKMF
239
EDYPKSRKAL
249
IPFIF
Residue
Distance (Å)
LEU20
4.076
LEU23
3.946
ALA24
3.663
VAL27
4.792
SER31
3.364
TYR33
2.934
GLY34
3.380
LYS35
2.853
TRP53
3.433
GLN56
3.813
GLU57
2.866
TYR91
4.479
ARG94
2.866
TYR98
3.074
ASN102
2.812
ARG103
3.959
GLY104
3.289
ARG105
3.079
TYR107
3.743
LEU111
3.862
ARG114
3.007
GLY115
3.849
PHE118
3.352
Residue
Distance (Å)
CYS119
4.690
ASN160
2.767
ASP164
2.730
LEU167
3.629
LEU170
3.738
ARG171
3.021
SER177
3.593
TYR178
2.804
ARG179
2.870
PRO181
4.176
ASN193
2.952
PHE194
3.472
GLU197
2.815
TRP201
3.195
PHE216
3.944
PHE219
3.687
SER220
3.126
PHE223
3.389
LEU224
3.795
ARG227
2.520
HIS231
2.768
TYR235
3.122
References  Top
REF 1 Structure of human steroid 5Alpha-reductase 2 with anti-androgen drug finasteride. Res Sq. 2020 Jul 15:rs.3.rs-40159.

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