Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T72702 | Target Info | |||
| Target Name | Tissue factor (F3) | ||||
| Synonyms | Thromboplastin; TF; F3; Coagulation factor III; CD142 antigen | ||||
| Target Type | Successful Target | ||||
| Gene Name | F3 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Gamma-Carboxy-Glutamic Acid | Ligand Info | |||||
| Structure Description | Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor | PDB:6R2W | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | Yes | [1] |
| PDB Sequence |
SGTTNTVAAY
10 NLTWKSTNFK20 TILEWEPKPV30 NQVYTVQIST40 KSGDWKSKCF50 YTTDTECDLT 60 DEIVKDVKQT70 YLARVFSYPA80 GNVESTGSAG90 EPLYENSPEF100 TPYLETNLGQ 110 PTIQSFEQVG120 TKVNVTVEDE130 RTLVRRNNTF140 LSLRDVFGKD150 LIYTLYYWKS 160 SSSGKKTAKT170 NTNEFLIDVD180 KGENYCFSVQ190 AVIPSRTVNR200 KSTDSPVECM 210
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Beta-L-fucose | Ligand Info | |||||
| Structure Description | Crystal Structure of tissue factor-factor VIIa complex | PDB:1J9C | ||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [2] |
| PDB Sequence |
SGTTNTVAAY
10 NLTWKSTNFK20 TILEWEPKPV30 NQVYTVQIST40 KSGDWKSKCF50 YTTDTECDLT 60 DEIVKDVKQT70 YLARVFSYPA80 GNVESTGSAG90 EPLYENSPEF100 TPYLETNLGQ 110 PTIQSFEQVG120 TKVNVTVEDE130 RTLVRRNNTF140 LSLRDVFGKD150 LIYTLYYWKS 160 SSSGKKTAKT170 NTNEFLIDVD180 KGENYCFSVQ190 AVIPSRTVNR200 KSTDSPVECM 210
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| Ligand Name: alpha-L-Fucose | Ligand Info | |||||
| Structure Description | Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor | PDB:6R2W | ||||
| Method | X-ray diffraction | Resolution | 1.25 Å | Mutation | Yes | [1] |
| PDB Sequence |
SGTTNTVAAY
10 NLTWKSTNFK20 TILEWEPKPV30 NQVYTVQIST40 KSGDWKSKCF50 YTTDTECDLT 60 DEIVKDVKQT70 YLARVFSYPA80 GNVESTGSAG90 EPLYENSPEF100 TPYLETNLGQ 110 PTIQSFEQVG120 TKVNVTVEDE130 RTLVRRNNTF140 LSLRDVFGKD150 LIYTLYYWKS 160 SSSGKKTAKT170 NTNEFLIDVD180 KGENYCFSVQ190 AVIPSRTVNR200 KSTDSPVECM 210
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .FUC or .FUC2 or .FUC3 or :3FUC;style chemicals stick;color identity;select .T:131 or .T:135 or .T:140; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Beating tissue factor at its own game: Design and properties of a soluble tissue factor-independent coagulation factor VIIa. J Biol Chem. 2020 Jan 10;295(2):517-528. | ||||
| REF 2 | Ligand Induced Conformational Transitions of Tissue Factor. Crystal Structure of the Tissue Factor:Factor VIIa Complex. | ||||
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