Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T77236 Target Info
Target Name Cathepsin F (CTSF)
Synonyms CATSF
Target Type Patented-recorded Target
Gene Name CTSF
Biochemical Class Peptidase
UniProt ID
CATF_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: N-[(2S)-1-[[(Z,3S)-1-(benzenesulfonyl)hex-1-en-3-yl]amino]-1-oxo-3-phenylpropan-2-yl]-4-morpholin-4-ylpiperidine-1-carboxamide Ligand Info
Structure Description Crystal structure of human cathepsin F PDB:1M6D
Method X-ray diffraction Resolution 1.70 Å Mutation Yes [1]
PDB Sequence
APPEWDWRSK
10
GAVTKVKDQG
20
MCGSCWAFSV
30
TGNVEGQWFL
40
NQGTLLSLSE
50

QELLDCDKMD
60
KACMGGLPSN
70
AYSAIKNLGG
79
LETEDDYSYQ
89
GHMQSCQFSA
99

EKAKVYIQDS
110
VELSQNEQKL
120
AAWLAKRGPI
130
SVAINAFGMQ
142
FYRHGISRPL
154A

RPLCSPWLID
158
HAVLLVGYGQ
167A
RSDVPFWAIK
174
NSWGTDWGEK
184
GYYYLHRGSG
198

ACGVNTMASS
208
AVVD
Residue
Distance (Å)
GLN19
3.004
CYS22
4.066
GLY23
3.420
SER24
4.582
CYS25
1.824
TRP26
3.209
CYS63
4.157
MET64
3.741
GLY65
3.099
GLY66
2.893
LEU67
3.537
Residue
Distance (Å)
PRO68
4.137
ALA133
3.839
ALA136
4.100
GLN142
3.246
ILE157
3.554
ASP158
3.048
HIS159
3.231
ALA160
4.561
TRP177
2.868
MET205
3.789
References  Top
REF 1 The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators. J Mol Biol. 2002 Sep 20;322(3):559-68.

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