Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78349 | Target Info | |||
| Target Name | ELAV-like protein 1 (ELAVL1) | ||||
| Synonyms | HuR; Hu-antigen R | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ELAVL1 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Diglyme | Ligand Info | |||||
| Structure Description | Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA | PDB:4ED5 | ||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
GRTNLIVNYL
27 PQNMTQDELR37 SLFSSIGEVE47 SAKLIRDKVA57 GHSLGYGFVN67 YVTAKDAERA 77 INTLNGLRLQ87 SKTIKVSYAR97 PSSEVIKDAN107 LYISGLPRTM117 TQKDVEDMFS 127 RFGRIINSRV137 LVDQTTGLSR147 GVAFIRFDKR157 SEAEEAITSF167 NGHKPPGSSE 177 PITVKFAA
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding. Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):373-80. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.