Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T78581 Target Info
Target Name Galanin receptor type 1 (GAL1-R)
Synonyms GALR1; GALR-1; GALNR1; GALN1R; GAL1-R
Target Type Literature-reported Target
Gene Name GALR1
Biochemical Class GPCR rhodopsin
UniProt ID
GALR1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Cholesterol Ligand Info
Structure Description Galanin-bound galanin receptor 1 in complex with Gi PDB:7WQ3
Method Electron microscopy Resolution 2.70 Å Mutation Yes [1]
PDB Sequence
ENFVTLVVFG
41
LIFALGVLGN
51
SLVITVLARS
61
KPGKPRSTTN
71
LFILNLSIAD
81

LAYLLFCIPF
91
QATVYALPTW
101
VLGAFICKFI
111
HYFFTVSMLV
121
SIFTLAAMSV
131

DRYVAIVHSR
141
RSSSLRVSRN
151
ALLGVGCIWA
161
LSIAMASPVA
171
YHQGLFHPRA
181

SNQTFCWEQW
191
PDPRHKKAYV
201
VCTFVFGYLL
211
PLLLICFCYA
221
KVLNHLHKKL
231

KNMSKKSEAS
241
KKKTAQTVLV
251
VVVVFGISWL
261
PHHIIHLWAE
271
FGVFPLTPAS
281

FLFRITAHCL
291
AYSNSSVNPI
301
IYAFLSENFR
311
KAYKQVFKC
Residue
Distance (Å)
PHE73
4.424
ALA105
4.551
PHE106
3.601
LYS109
4.177
PHE110
3.593
TYR113
4.337
PHE124
3.976
ALA127
3.735
ALA128
3.753
VAL131
3.723
ASP132
4.430
LEU146
3.973
ARG147
3.361
VAL148
4.644
ASN151
3.298
GLY155
4.052
ILE159
3.859
ILE164
3.732
SER168
4.143
Residue
Distance (Å)
TYR172
3.517
ARG195
3.742
LYS198
4.769
ALA199
3.783
VAL202
3.741
VAL206
4.419
PHE207
4.235
LEU211
4.326
PRO212
4.131
LEU215
4.444
CYS217
4.242
TYR220
4.721
ALA221
3.717
LEU224
3.760
ASN225
4.880
HIS228
3.557
VAL249
4.126
VAL253
3.729
References  Top
REF 1 Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. doi:10.1038/s41467-022-29072-3.

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