Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T79062 | Target Info | |||
| Target Name | 5-HT 7 receptor (HTR7) | ||||
| Synonyms | Serotonin receptor 7; 5HT7; 5-hydroxytryptamine receptor 7; 5-HT7 receptor; 5-HT7; 5-HT-X; 5-HT-7 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | HTR7 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-CT | Ligand Info | |||||
| Structure Description | Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex | PDB:7XTC | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
EKVVIGSILT
89 LITLLTIAGN99 CLVVISVCFV109 KKLRQPSNYL119 IVSLALADLS129 VAVAVMPFVS 139 VTDLIGGKWI149 FGHFFCNVFI159 AMDVMCCTAS169 IMTLCVISID179 RYLGITRPLT 189 YPVRQNGKCM199 AKMILSVWLL209 SASITLPPLF219 GWAQNVNDDK229 VCLISQDFGY 239 TIYSTAVAFY249 IPMSVMLFMY259 YQIYKAARKS269 AAKHKFPGFP279 KAATTLGIIV 333 GAFTVCWLPF343 FLLSTARPFI353 CCIPLWVERT368 FLWLGYANSL378 INPFIYAFFN 388 RDLRTTYRSL398 LQCQY
|
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VAL134
4.819
ASP162
2.202
VAL163
2.405
CYS166
2.057
THR167
2.747
ILE213
2.824
ILE233
2.582
SER234
4.547
GLN235
3.609
TYR239
4.477
THR240
2.850
|
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Serotonin 7 (5-HT7) receptor-Gs-Nb35 complex | PDB:7XTC | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
EKVVIGSILT
89 LITLLTIAGN99 CLVVISVCFV109 KKLRQPSNYL119 IVSLALADLS129 VAVAVMPFVS 139 VTDLIGGKWI149 FGHFFCNVFI159 AMDVMCCTAS169 IMTLCVISID179 RYLGITRPLT 189 YPVRQNGKCM199 AKMILSVWLL209 SASITLPPLF219 GWAQNVNDDK229 VCLISQDFGY 239 TIYSTAVAFY249 IPMSVMLFMY259 YQIYKAARKS269 AAKHKFPGFP279 KAATTLGIIV 333 GAFTVCWLPF343 FLLSTARPFI353 CCIPLWVERT368 FLWLGYANSL378 INPFIYAFFN 388 RDLRTTYRSL398 LQCQY
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | GPCRs steer G(i) and G(s) selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol Cell. 2022 Jul 21;82(14):2681-2695.e6. | ||||
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