Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T79473 Target Info
Target Name Luteinizing hormone receptor (LHCGR)
Synonyms Luteinizing hormone-releasing hormone receptor; LSH-R; LHRH receptor; LHCGR; LH/CG-R
Target Type Successful Target
Gene Name LHCGR
Biochemical Class GPCR rhodopsin
UniProt ID
LSHR_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: CID 9914457 Ligand Info
Structure Description luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex PDB:7FIH
Method Electron microscopy Resolution 3.20 Å Mutation Yes [1]
PDB Sequence
TRLSLAYLPV
61
KVIPSQAFRG
71
LNEVIKIEIS
81
QIDSLERIEA
91
NAFDNLLNLS
101

EILIQNTKNL
111
RYIEPGAFIN
121
LPRLKYLSIC
131
NTGIRKFPDV
141
TKVFSSESNF
151

ILEICDNLHI
161
TTIPGNAFQG
171
MNNESVTLKL
181
YGNGFEEVQS
191
HAFNGTTLTS
201

LELKENVHLE
211
KMHNGAFRGA
221
TGPKTLDISS
231
TKLQALPSYG
241
LESIQRLIAT
251

SSYSLKKLPS
261
RETFVNLLEA
271
TLTYPIHCCA
281
FRNLPDYEYG
334
FCLPKTPRCA
344

PEPDAFNPCE
354
DIMGYDFLRV
364
LIWLINILAI
374
MGNMTVLFVL
384
LTSRYKLTVP
394

RFLMCNLSFA
404
DFCMGLYLLL
414
IASVDSQTKG
424
QYYNHAIDWQ
434
TGSGCSTAGF
444

FTVFASELSV
454
YTLTVITLER
464
WHTITYAIHL
474
DQKLRLRHAI
484
LIMLGGWLFS
494

SLIAMLPLVG
504
VSNYMKVSIC
514
FPMDVETTLS
524
QVYILTILIL
534
NVVAFFIICA
544

CYIKIYFAVR
554
NPELMATNKD
564
TKIAKKMAIL
574
IFTDFTCMAP
584
ISFFAISAAF
594

KVPLITVTNS
604
KVLLVLFYPI
614
NSCANPFLYA
624
IFTKTFQRDF
634
FLLLSKFGCC
644
Residue
Distance (Å)
ALA349
4.194
PHE350
3.344
THR446
4.519
VAL447
3.960
SER450
4.066
GLU451
3.534
PHE515
3.209
PRO516
3.374
MET517
3.490
VAL519
3.413
ILE528
3.667
ILE531
3.520
LEU532
4.732
ASN535
4.404
Residue
Distance (Å)
ILE585
4.480
PHE588
4.250
ALA589
3.843
ALA592
3.580
ALA593
4.332
LYS595
3.411
PRO597
3.266
ILE599
3.864
THR600
4.595
VAL601
3.493
SER604
2.779
LEU607
4.900
TYR612
3.781
References  Top
REF 1 Structures of full-length glycoprotein hormone receptor signalling complexes. Nature. 2021 Oct;598(7882):688-692.

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