Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T86264 Target Info
Target Name Solute carrier family 40 member 1 (SLC40A1)
Synonyms SLC11A3; MSTP079; IREG1; Ferroportin-1; FPN1
Target Type Clinical trial Target
Gene Name SLC40A1
Biochemical Class Ferroportin protein
UniProt ID
S40A1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: (1S)-2-{[{[(2S)-2,3-Dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(pentanoyloxy)methyl]ethyl octanoate Ligand Info
Structure Description Structure of human ferroportin bound to hepcidin and cobalt in lipid nanodisc PDB:6WBV
Method Electron microscopy Resolution 2.50 Å Mutation No [1]
PDB Sequence
SLADYLTSAK
25
FLLYLGHSLS
35
TWGDRMWHFA
45
VSVFLVELYG
55
NSLLLTAVYG
65

LVVAGSVLVL
75
GAIIGDWVDK
85
NARLKVAQTS
95
LVVQNVSVIL
105
CGIILMMVFL
115

HKHELLTMYH
125
GWVLTSCYIL
135
IITIANIANL
145
ASTATAITIQ
155
RDWIVVVAGE
165

DRSKLANMNA
175
TIRRIDQLTN
185
ILAPMAVGQI
195
MTFGSPVIGC
205
GFISGWNLVS
215

MCVEYVLLWK
225
VYQKTPALAV
235
KAGAEPFRTF
295
RDGWVSYYNQ
305
PVFLAGMGLA
315

FLYMTVLGFD
325
CITTGYAYTQ
335
GLSGSILSIL
345
MGASAITGIM
355
GTVAFTWLRR
365

KCGLVRTGLI
375
SGLAQLSCLI
385
LCVISVFMPG
395
SPLPIISVSL
457
LFAGVIAARI
467

GLWSFDLTVT
477
QLLQENVIES
487
ERGIINGVQN
497
SMNYLLDLLH
507
FIMVILAPNP
517

EAFGLLVLIS
527
VSFVAMGHIM
537
YFRFAQNTL
Residue
Distance (Å)
TYR20
2.885
LEU21
3.517
THR22
3.188
LYS25
4.044
PHE26
3.655
LEU27
3.601
TYR29
3.309
LEU30
4.432
SER33
3.616
ASN172
3.736
Residue
Distance (Å)
THR176
3.254
ARG179
3.316
ILE180
3.760
LEU183
3.989
THR184
4.800
VAL218
3.881
VAL221
4.533
LEU222
4.447
LYS225
2.325
LYS229
3.405
References  Top
REF 1 Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature. 2020 Oct;586(7831):807-811.

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