Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T88404 Target Info
Target Name Optic atrophy protein 1 (OPA1)
Synonyms OPA1; Dynaminlike 120 kDa protein, mitochondrial; Dynaminlike 120 kDa protein, form S1
Target Type Literature-reported Target
Gene Name OPA1
Biochemical Class Carbon-carbon hydrolase
UniProt ID
OPA1_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Guanosine-5'-Diphosphate Ligand Info
Structure Description Structural insights into G domain dimerization and pathogenic mutations of OPA1 PDB:6JTG
Method X-ray diffraction Resolution 2.40 Å Mutation No [1]
PDB Sequence
SLIDMYSEVL
10
DVLSDYDASY
20
NTQDHLPRVV
30
VVGDQSAGKT
40
SVLEMIAQAR
50

IFPRGSGEMM
60
TRSPVKVTLS
70
EGPHHVALFK
80
DSSREFDLTK
90
EEDLAALRHE
100

IELRMRKNVK
110
EGCTVSPETI
120
SLNVKGPGLQ
130
RMVLVDLPGV
140
INTVTSGMAP
150

DTKETIFSIS
160
KAYMQNPNAI
170
ILCIQDGSVD
180
AERSIVTDLV
190
SQMDPHGRRT
200

IFVLTKVDLA
210
EKNVASPSRI
220
QQIIEGKLFP
230
MKALGYFAVV
240
TGKGNSSESI
250

EAIREYEEEF
260
FQNSKLLKTS
270
MLKAHQVTTR
280
NLSLAVSDCF
290
WKMVRESVEQ
300

QADSFKATRF
310
NLEVREIQEK
338
LDAFIEALHQ
348
Residue
Distance (Å)
ASP34
3.878
GLN35
4.215
SER36
3.056
ALA37
3.303
GLY38
2.759
LYS39
2.695
THR40
2.772
SER41
2.595
PRO53
4.654
ARG54
3.430
GLY55
2.912
SER56
3.047
MET60
4.525
THR61
4.416
Residue
Distance (Å)
ASP136
4.805
THR205
4.315
LYS206
3.102
VAL207
4.702
ASP208
2.876
LEU209
3.363
VAL239
3.973
VAL240
3.211
THR241
2.731
GLY242
2.869
LYS243
3.624
GLY244
3.568
TYR256
4.942
References  Top
REF 1 Structural insights into G domain dimerization and pathogenic mutation of OPA1. J Cell Biol. 2020 Jul 6;219(7):e201907098.

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