Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T88415 Target Info
Target Name Receptor-type protein-tyrosine phosphatase zeta (PTPRZ1)
Synonyms Receptor protein tyrosine phosphatase zeta; R-PTP-zeta; PTPRZ1
Target Type Literature-reported Target
Gene Name PTPRZ1
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTPRZ_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 3-{[2-Ethoxy-5-(Trifluoromethyl)benzyl]sulfanyl}-N-(Phenylsulfonyl)thiophene-2-Carboxamide Ligand Info
Structure Description Human PTPRZ D1 domain complexed with NAZ2329 PDB:5H08
Method X-ray diffraction Resolution 2.53 Å Mutation No [1]
PDB Sequence
GPAIPIKHFP
1705
KHVADLHASS
1715
GFTEEFEEVQ
1732
SCTVDLGITA
1742
DSSNHPDNKH
1752

KNRYINIVAY
1762
DHSRVKLAQL
1772
AEKDGKLTDY
1782
INANYVDGYN
1792
RPKAYIAAQG
1802

PLKSTAEDFW
1812
RMIWEHNVEV
1822
IVMITNLVEK
1832
GRRKCDQYWP
1842
ADGSEEYGNF
1852

LVTQKSVQVL
1862
AYYTVRNFTL
1872
RNTKIRVVTQ
1893
YHYTQWPDMG
1903
VPEYSLPVLT
1913

FVRKAAYAKR
1923
HAVGPVVVHC
1933
SAGVGRTGTY
1943
IVLDSMLQQI
1953
QHEGTVNIFG
1963

FLKHIRSQRN
1973
YLVQTEEQYV
1983
FIHDTLVEAI
1993
LS
Residue
Distance (Å)
ILE1826
3.610
GLU1831
4.970
TYR1896
3.697
GLN1898
3.589
TRP1899
3.294
PRO1900
4.583
VAL1904
4.600
PRO1905
3.322
GLU1906
4.131
VAL1911
3.807
PHE1914
4.201
Residue
Distance (Å)
VAL1915
3.621
GLY1938
3.712
ARG1939
2.786
THR1942
3.947
TYR1943
3.370
LEU1946
3.571
GLN1977
3.034
THR1978
3.947
GLU1980
3.629
GLN1981
3.215
PHE1984
3.402
References  Top
REF 1 Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells. Sci Rep. 2017 Jul 17;7(1):5609.

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