Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89055 | Target Info | |||
| Target Name | ERK activator kinase 2 (MEK2) | ||||
| Synonyms | PRKMK2; MKK2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; Dual specificity mitogenactivated protein kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MAP2K2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP | PDB:1S9I | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
QKAKVGELKD
69 DDFERISELG79 AGNGGVVTKV89 QHRPSGLIMA99 RKLIHLEIKP109 AIRNQIIREL 119 QVLHECNSPY129 IVGFYGAFYS139 DGEISICMEH149 MDGGSLDQVL159 KEAKRIPEEI 169 LGKVSIAVLR179 GLAYLREKHQ189 IMHRDVKPSN199 ILVNSRGEIK209 LCDFGVSGQL 219 IDSMVGTRSY233 MAPERLQGTH243 YSVQSDIWSM253 GLSLVELAVG263 RYPIPPPDAK 273 ELEAIFGRPV283 VDRPAMAIFE320 LLDYIVNEPP330 PKLPNGVFTP340 DFQEFVNKCL 350 IKNPAERADL360 KMLTNHTFIK370 RSEVEEVDFA380 GWLCKTLRLN390 QPG |
|||||
|
|
LEU78
3.604
GLY79
3.766
ALA80
3.733
GLY81
3.294
ASN82
3.329
GLY84
3.705
VAL85
4.565
VAL86
3.315
ALA99
3.651
LYS101
2.590
VAL131
4.165
MET147
3.368
GLU148
2.913
|
|||||
| Ligand Name: 5-{3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-N-(2-morpholin-4-ylethyl)-1,3,4-oxadiazol-2-amine | Ligand Info | |||||
| Structure Description | X-ray structure of the human mitogen-activated protein kinase kinase 2 (MEK2)in a complex with ligand and MgATP | PDB:1S9I | ||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
QKAKVGELKD
69 DDFERISELG79 AGNGGVVTKV89 QHRPSGLIMA99 RKLIHLEIKP109 AIRNQIIREL 119 QVLHECNSPY129 IVGFYGAFYS139 DGEISICMEH149 MDGGSLDQVL159 KEAKRIPEEI 169 LGKVSIAVLR179 GLAYLREKHQ189 IMHRDVKPSN199 ILVNSRGEIK209 LCDFGVSGQL 219 IDSMVGTRSY233 MAPERLQGTH243 YSVQSDIWSM253 GLSLVELAVG263 RYPIPPPDAK 273 ELEAIFGRPV283 VDRPAMAIFE320 LLDYIVNEPP330 PKLPNGVFTP340 DFQEFVNKCL 350 IKNPAERADL360 KMLTNHTFIK370 RSEVEEVDFA380 GWLCKTLRLN390 QPG |
|||||
|
|
GLY81
4.747
ASN82
3.131
GLY83
4.692
LYS101
3.063
ILE103
4.917
LEU119
3.258
LEU122
3.620
ILE130
4.871
VAL131
3.250
GLY132
3.953
PHE133
4.781
ILE145
3.745
MET147
3.479
ARG193
3.540
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. | ||||
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