Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T89213 Target Info
Target Name Neuropeptide Y receptor type 1 (NPY1R)
Synonyms Neuropeptide Y-Y1 receptor; Neuropeptide Y receptor Y1; Neuropeptide Y Y(1) receptor; NPY1R; NPY1-R
Target Type Clinical trial Target
Gene Name NPY1R
Biochemical Class GPCR rhodopsin
UniProt ID
NPY1R_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino)ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide Ligand Info
Structure Description The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299 PDB:5ZBQ
Method X-ray diffraction Resolution 2.70 Å Mutation Yes [1]
PDB Sequence
FSEKNAQLLA
27
FENDDCHLPL
37
AMIFTLALAY
47
GAVIILGVSG
57
NLALIIIILK
67

QKEMRNVTNI
77
LIVNLSFSDL
87
LVAIMCLPFT
97
FVYTLMDHWV
107
FGEAMCKLNP
117

FVQCVSITVS
127
IWSLVLIAVE
137
RHQLIINPRG
147
WRPNNRHAYV
157
GIAVIWVLAV
167

ASSLPFLIYQ
177
VMTDEPFQNV
187
TLDAYKDKYV
197
CFDQFPSDSH
207
RLSYTTLLLV
217

LQYFGPLCFI
227
FICYFKIYIR
237
LKRRSETKRI
261
NIMLLSIVVA
271
FAVCWLPLTI
281

FNTVFDWNHQ
291
IIATCNHNLL
301
FLLCHLTAMI
311
STCVNPIFYG
321
FLNKNFQRDL
331

QFFFNFNIFE
1004
MLRIDEGLRL
1014
KIYKDTEGYY
1024
TIGIGHLLTK
1034
SPSLNAAKSE
1044

LDKAIGRNTN
1054
GVITKDEAEK
1064
LFNQDVDAAV
1074
RGILRNAKLK
1084
PVYDSLDAVR
1094

RAALINMVFQ
1104
MGETGVAGFT
1114
NSLRMLQQKR
1124
WDEAAVNSRW
1137
YNQTPNRAKR
1147

VITTFRTGTW
1157
DAY
Residue
Distance (Å)
LEU26
3.880
PRO117
3.586
GLN120
3.453
CYS121
3.564
ILE124
3.537
PHE173
3.428
ASP200
3.983
THR212
2.818
LEU215
4.117
LEU216
3.831
GLN219
3.014
TYR220
4.312
TRP276
4.041
Residue
Distance (Å)
LEU279
3.828
THR280
3.366
PHE282
3.638
ASN283
2.754
THR284
3.837
PHE286
3.470
ASP287
2.785
HIS290
3.836
ALA294
4.118
HIS298
3.955
ASN299
4.334
PHE302
3.195
HIS306
4.355
References  Top
REF 1 Structural basis of ligand binding modes at the neuropeptide Y Y(1) receptor. Nature. 2018 Apr;556(7702):520-524.

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