Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89515 | Target Info | |||
| Target Name | Polypeptide deformylase (PDF) | ||||
| Synonyms | |||||
| Target Type | Successful Target | ||||
| Gene Name | |||||
| Biochemical Class | CH-NH donor oxidoreductase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Actinonin | Ligand Info | |||||
| Structure Description | Structure and activity of human mitochondrial peptide deformylase, a novel cancer target | PDB:3G5K | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [1] |
| PDB Sequence |
HMSFSHVCQV
12 GDPVLRGVAA22 PVERAQLGGP32 ELQRLTQRLV42 QVMRRRRCVG52 LSAPQLGVPR 62 QVLALELPEA72 LCRECPPRQR82 ALRQMEPFPL92 RVFVNPSLRV102 LDSRLVTFPE 112 GCESVAGFLA122 CVPRFQAVQI132 SGLDPNGEQV142 VWQASGWAAR152 IIQHEMDHLQ 162 GCLFIDKMDS172 RTFTNVYWMK182 VND
|
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ARG49
4.673
CYS50
3.511
VAL51
3.263
GLY52
2.896
LEU53
4.176
SER54
4.815
GLN57
2.949
ARG85
4.640
PRO111
2.698
GLU112
3.465
GLY113
2.920
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure and activity of human mitochondrial peptide deformylase, a novel cancer target. J Mol Biol. 2009 Apr 17;387(5):1211-28. | ||||
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