Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90553 | Target Info | |||
| Target Name | Microtubule affinity regulating kinase 3 (MARK3) | ||||
| Synonyms | cTAK1; Serine/threonine-protein kinase p78; Ser/Thr protein kinase PAR-1; Protein kinase STK10); Protein kinase STK10; Par-1a; MAP/microtubule affinity-regulating kinase 3; EMK2; EMK-2; ELKL motif kinase 2; Cdc25C-associated protein kinase 1; C-TAK1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MARK3 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 5-bromo-4-N-[2-(1H-imidazol-5-yl)ethyl]-2-N-[3-(morpholin-4-ylmethyl)phenyl]pyrimidine-2,4-diamine | Ligand Info | |||||
| Structure Description | The MARK3 Kinase Domain Bound To AA-CS-1-008 | PDB:7P1L | ||||
| Method | X-ray diffraction | Resolution | 1.95 Å | Mutation | No | [1] |
| PDB Sequence |
QPHIGNYRLL
59 KTIGKGNFAK69 VKLARHILTG79 REVAIKIIDK89 TQLNPTSLQK99 LFREVRIMKI 109 LNHPNIVKLF119 EVIETEKTLY129 LIMEYASGGE139 VFDYLVAHGR149 MKEKEARSKF 159 RQIVSAVQYC169 HQKRIVHRDL179 KAENLLLDAD189 MNIKIADFGF199 SNEFTVSPPY 218 AAPELDGPEV234 DVWSLGVILY244 TLVSGSLPFD254 GQNLKELRER264 VLRGKYRIPF 274 YMSTDCENLL284 KRFLVLNPIK294 RGTLEQIMKD304 RWINAGHEED314 ELKPFVEPEL 324 DISDQKRIDI334 MVGMGYSQEE344 IQESLSKMKY354 DEITATYLLL364 G |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. J Med Chem. 2022 Jan 27;65(2):1313-1328. | ||||
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