Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T90828 | Target Info | |||
| Target Name | Interleukin 5 receptor alpha (IL5RA) | ||||
| Synonyms | Interleukin-5 receptor subunit alpha; IL5R; IL-5RA; IL-5R-alpha; IL-5R subunit alpha; IL-5 receptor subunit alpha; CDw125; CD125 | ||||
| Target Type | Successful Target | ||||
| Gene Name | IL5RA | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Beta-D-Glucose | Ligand Info | |||||
| Structure Description | Structure of a cytokine ligand-receptor complex | PDB:3QT2 | ||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | Yes | [1] |
| PDB Sequence |
KISLLPPVNF
16 TIKVTGLAQV26 LLQWKPNPDQ36 EQRNVNLEYQ46 VKINAPKEDD56 YETRITESKA 66 VTILHMGFSA76 SVRTILQNDH86 SLLASSWASA96 ELHAPPGSPG106 TSIVNLTCTT 116 NTTEDNYSRL126 RSYQVSLHCT136 WMVGTDAPED146 TQYFLYYRYG156 SWTEECQEYS 166 MDTLGRNIAC176 WFPRTFILSK186 GRDWLAVLVN196 GSSKHSAIRP206 FDQLFALHAI 216 DQINPPLNVT226 AEIEGTRMSI236 QWEKPVSAFP246 IHCFDYEVKI256 HNTRNGYLQI 266 EKLMTNAFIS276 IIDDLSKYDV286 QVRAAVSSMC296 REAGLWSEWS306 QPIYVGF |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5RAlpha. Structure. 2011 Dec 7;19(12):1864-75. | ||||
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