Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92078 | Target Info | |||
| Target Name | Dihydropyrimidinase related protein 2 (DPYSL2) | ||||
| Synonyms | Unc33like phosphoprotein 2; Unc-33-like phosphoprotein 2; ULIP2; ULIP-2; N2A3; Dihydropyrimidinaserelated protein 2; Dihydropyrimidinase-related protein 2; DRP2; DRP-2; Collapsin response mediator protein 2; CRMP2; CRMP-2 | ||||
| Target Type | Successful Target | ||||
| Gene Name | DPYSL2 | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: 1beta-Hydroxyalantolactone | Ligand Info | |||||
| Structure Description | CYS179 and CYS504 of CRMP2 were covalently binded by a Sesquiterpene lactone | PDB:7X68 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
DRLLIKGGKI
24 VNDDQSFYAD34 IYMEDGLIKQ44 IGENLIVPGG54 VKTIEAHSRM64 VIPGGIDVHT 74 RFQMPDQGMT84 SADDFFQGTK94 AALAGGTTMI104 IDHVVPEPGT114 SLLAAFDQWR 124 EWADSKSCCD134 YSLHVDISEW144 HKGIQEEMEA154 LVKDHGVNSF164 LVYMAFKDRF 174 QLTDCQIYEV184 LSVIRDIGAI194 AQVHAENGDI204 IAEEQQRILD214 LGITGPEGHV 224 LSRPEEVEAE234 AVNRAITIAN244 QTNCPLYITK254 VMSKSSAEVI264 AQARKKGTVV 274 YGEPITASLG284 TDGSHYWSKN294 WAKAAAFVTS304 PPLSPDPTTP314 DFLNSLLSCG 324 DLQVTGSAHC334 TFNTAQKAVG344 KDNFTLIPEG354 TNGTEERMSV364 IWDKAVVTGK 374 MDENQFVAVT384 STNAAKVFNL394 YPRKGRIAVG404 SDADLVIWDP414 DSVKTISAKT 424 HNSSLEYNIF434 EGMECRGSPL444 VVISQGKIVL454 EDGTLHVTEG464 SGRYIPRKPF 474 PDFVYKRIKA484 RSRLAELRGV494 PRGLYDGPVC504 E
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | CYS179 and CYS504 of CRMP2 were covalently binded by a Sesquiterpene lactone | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.