Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92403 | Target Info | |||
| Target Name | Sodium/hydrogen exchanger 3 (SLC9A3) | ||||
| Synonyms | SLC9A3; Na(+)/H(+) exchanger 3; NHE-3 | ||||
| Target Type | Successful Target | ||||
| Gene Name | SLC9A3 | ||||
| Biochemical Class | Monovalent cation:proton antiporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (1s)-2-{[{[(2r)-2,3-Dihydroxypropyl]oxy}(Hydroxy)phosphoryl]oxy}-1-[(Palmitoyloxy)methyl]ethyl Stearate | Ligand Info | |||||
| Structure Description | Structure of a human NHE3-CHP1 complex in the autoinhibited state | PDB:7X2U | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
GGFQVVTFEW
49 AHVQDPYVIA59 LWILVASLAK69 IGFHLSHKVT79 SVVPESALLI89 VLGLVLGGIV 99 WAADHIASFT109 LTPTVFFFYL119 LPPIVLDAGY129 FMPNRLFFGN139 LGTILLYAVV 149 GTVWNAATTG159 LSLYGVFLSG169 LMGDLQIGLL179 DFLLFGSLMA189 AVDPVAVLAV 199 FEEVHVNEVL209 FIIVFGESLL219 NDAVTVVLYN229 VFESFVALGG239 DNVTGVDCVK 249 GIVSFFVVSL259 GGTLVGVVFA269 FLLSLVTRFT279 KHVRIIEPGF289 VFIISYLSYL 299 TSEMLSLSAI309 LAITFCGICC319 QKYVKANISE329 QSATTVRYTM339 KMLASSAETI 349 IFMFLGISAV359 NPFIWTWNTA369 FVLLTLVFIS379 VYRAIGVVLQ389 TWLLNRYRMV 399 QLEPIDQVVL409 SYGGLRGAVA419 FALVVLLDGD429 KVKEKNLFVS439 TTIIVVFFTV 449 IFQGLTIKPL459 VQWLKVRLNE477 KLHGRAFDHI487 LSAIEDISGQ497 IGHNYLRDKW 507 SHFDRKFLSR517 VLMRRSAQKS527 RDRILNVFHE537 LNHHTLQQYL624 YKPRQEYKHL 634 YSRHELTPTE644 DEKQDREIFH654 RTMRKRLESF664 K
|
|||||
|
|
TRP49
4.017
GLN53
3.422
ASP54
3.547
VAL57
3.786
ILE58
3.939
LEU60
4.601
TRP61
3.906
ILE62
4.057
LEU95
4.049
ILE98
3.952
VAL99
3.756
ALA102
3.955
HIS104
3.735
SER107
3.565
PHE108
3.444
THR109
3.647
THR111
4.307
THR113
4.253
|
|||||
| Ligand Name: D-myo-Inositol 1-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl hydrogen phosphate] | Ligand Info | |||||
| Structure Description | Structure of a human NHE3-CHP1 complex in the autoinhibited state | PDB:7X2U | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
GGFQVVTFEW
49 AHVQDPYVIA59 LWILVASLAK69 IGFHLSHKVT79 SVVPESALLI89 VLGLVLGGIV 99 WAADHIASFT109 LTPTVFFFYL119 LPPIVLDAGY129 FMPNRLFFGN139 LGTILLYAVV 149 GTVWNAATTG159 LSLYGVFLSG169 LMGDLQIGLL179 DFLLFGSLMA189 AVDPVAVLAV 199 FEEVHVNEVL209 FIIVFGESLL219 NDAVTVVLYN229 VFESFVALGG239 DNVTGVDCVK 249 GIVSFFVVSL259 GGTLVGVVFA269 FLLSLVTRFT279 KHVRIIEPGF289 VFIISYLSYL 299 TSEMLSLSAI309 LAITFCGICC319 QKYVKANISE329 QSATTVRYTM339 KMLASSAETI 349 IFMFLGISAV359 NPFIWTWNTA369 FVLLTLVFIS379 VYRAIGVVLQ389 TWLLNRYRMV 399 QLEPIDQVVL409 SYGGLRGAVA419 FALVVLLDGD429 KVKEKNLFVS439 TTIIVVFFTV 449 IFQGLTIKPL459 VQWLKVRLNE477 KLHGRAFDHI487 LSAIEDISGQ497 IGHNYLRDKW 507 SHFDRKFLSR517 VLMRRSAQKS527 RDRILNVFHE537 LNHHTLQQYL624 YKPRQEYKHL 634 YSRHELTPTE644 DEKQDREIFH654 RTMRKRLESF664 K
|
|||||
|
|
GLY138
2.262
ASN139
3.339
LEU140
3.929
GLY141
3.145
THR142
2.894
LEU144
3.808
LEU145
3.763
VAL148
3.792
VAL149
3.985
VAL152
3.616
TRP153
4.602
PHE254
4.709
PHE255
3.701
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of a human NHE3-CHP1 complex in the autoinhibited state | ||||
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