Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T93653 Target Info
Target Name Cathepsin V (CTSV)
Synonyms UNQ268/PRO305; Cathepsin U; Cathepsin L2; CTSU; CTSL2; CATL2
Target Type Patented-recorded Target
Gene Name CTSV
Biochemical Class Peptidase
UniProt ID
CATL2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: Nalpha-[(4-Methylpiperazin-1-Yl)carbonyl]-N-[(3s)-1-Phenyl-5-(Phenylsulfonyl)pentan-3-Yl]-L-Phenylalaninamide Ligand Info
Structure Description CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR PDB:1FH0
Method X-ray diffraction Resolution 1.60 Å Mutation Yes [1]
PDB Sequence
LPKSVDWRKK
10
GYVTPVKNQK
20
QCGSCWAFSA
30
TGALEGQMFR
40
KTGKLVSLSE
50

QNLVDCSRPQ
60
GNQGCNGGFM
70
ARAFQYVKEN
80
GGLDSEESYP
90
YVAVDEICKY
100

RPENSVAQDT
110
GFTVVAPGKE
119
KALMKAVATV
129
GPISVAMDAG
139
HSSFQFYKSG
149

IYFEPDCSSK
159
NLDHGVLVVG
169
YGFEGANSDN
179
SKYWLVKNSW
189
GPEWGSNGYV
199

KIAKDKNNHC
209
GIATAASYPN
219
V
Residue
Distance (Å)
GLN19
2.887
CYS22
4.618
GLY23
3.500
SER24
4.765
CYS25
1.793
TRP26
3.148
GLY61
3.738
GLN63
3.596
CYS65
3.457
ASN66
3.417
GLY67
3.126
GLY68
2.896
Residue
Distance (Å)
PHE69
3.350
MET70
4.009
ALA135
3.416
ALA138
3.839
GLY139
4.261
LEU161
3.795
ASP162
3.156
HIS163
3.132
GLY164
4.073
TRP189
2.966
ALA214
4.599
References  Top
REF 1 Crystal structure of human cathepsin V. Biochemistry. 2000 Oct 17;39(41):12543-51.

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