Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T94309 | Target Info | |||
| Target Name | Pancreatic triacylglycerol lipase (PNLIP) | ||||
| Synonyms | Pancreatic lipase; PTL; PL | ||||
| Target Type | Successful Target | ||||
| Gene Name | PNLIP | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: B-Octylglucoside | Ligand Info | |||||
| Structure Description | THE 2.46 ANGSTROMS RESOLUTION STRUCTURE OF THE PANCREATIC LIPASE COLIPASE COMPLEX INHIBITED BY A C11 ALKYL PHOSPHONATE | PDB:1LPB | ||||
| Method | X-ray diffraction | Resolution | 2.46 Å | Mutation | No | [1] |
| PDB Sequence |
KEVCYERLGC
10 FSDDSPWSGI20 TERPLHILPW30 SPKDVNTRFL39 LYTNENPNNF49 QEVAADSSSI 59 SGSNFKTNRK69 TRFIIHGFID79 KGEENWLANV89 CKNLFKVESV99 NCICVDWKGG 109 SRTGYTQASQ119 NIRIVGAEVA129 YFVEFLQSAF139 GYSPSNVHVI149 GHSLGAHAAG 159 EAGRRTNGTI169 GRITGLDPAE179 PCFQGTPELV189 RLDPSDAKFV199 DVIHTDGAPI 209 VPNLGFGMSQ219 VVGHLDFFPN229 GGVEMPGCKK239 NILSQIVDID249 GIWEGTRDFA 259 ACNHLRSYKY269 YTDSIVNPDG279 FAGFPCASYN289 VFTANKCFPC299 PSGGCPQMGH 309 YADRYPGKTN319 DVGQKFYLDT329 GDASNFARWR339 YKVSVTLSGK349 KVTGHILVSL 359 FGNKGNSKQY369 EIFKGTLKPD379 STHSNEFDSD389 VDVGDLQMVK399 FIWYNNVINP 410 TLPRVGASKI420 IVETNVGKQF430 NFCSPETVRE440 EVLLTLTPC
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LYS239
3.215
ASP247
2.918
ILE248
3.198
ASP331
2.570
ALA332
3.020
PHE77
4.954
ILE78
3.863
LYS80
2.143
GLU82
4.131
GLU83
3.347
ASN84
3.423
ARG111
3.690
LEU213
4.352
PHE215
3.604
GLU233
4.516
LYS238
3.312
LYS239
4.304
GLN244
4.683
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| Ligand Name: METHOXYUNDECYLPHOSPHINIC ACID | Ligand Info | |||||
| Structure Description | THE 2.46 ANGSTROMS RESOLUTION STRUCTURE OF THE PANCREATIC LIPASE COLIPASE COMPLEX INHIBITED BY A C11 ALKYL PHOSPHONATE | PDB:1LPB | ||||
| Method | X-ray diffraction | Resolution | 2.46 Å | Mutation | No | [1] |
| PDB Sequence |
KEVCYERLGC
10 FSDDSPWSGI20 TERPLHILPW30 SPKDVNTRFL39 LYTNENPNNF49 QEVAADSSSI 59 SGSNFKTNRK69 TRFIIHGFID79 KGEENWLANV89 CKNLFKVESV99 NCICVDWKGG 109 SRTGYTQASQ119 NIRIVGAEVA129 YFVEFLQSAF139 GYSPSNVHVI149 GHSLGAHAAG 159 EAGRRTNGTI169 GRITGLDPAE179 PCFQGTPELV189 RLDPSDAKFV199 DVIHTDGAPI 209 VPNLGFGMSQ219 VVGHLDFFPN229 GGVEMPGCKK239 NILSQIVDID249 GIWEGTRDFA 259 ACNHLRSYKY269 YTDSIVNPDG279 FAGFPCASYN289 VFTANKCFPC299 PSGGCPQMGH 309 YADRYPGKTN319 DVGQKFYLDT329 GDASNFARWR339 YKVSVTLSGK349 KVTGHILVSL 359 FGNKGNSKQY369 EIFKGTLKPD379 STHSNEFDSD389 VDVGDLQMVK399 FIWYNNVINP 410 TLPRVGASKI420 IVETNVGKQF430 NFCSPETVRE440 EVLLTLTPC
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| Ligand Name: B-Nonylglucoside | Ligand Info | |||||
| Structure Description | INTERFACIAL ACTIVATION OF THE LIPASE-PROCOLIPASE COMPLEX BY MIXED MICELLES REVEALED BY X-RAY CRYSTALLOGRAPHY | PDB:1LPA | ||||
| Method | X-ray diffraction | Resolution | 3.04 Å | Mutation | No | [2] |
| PDB Sequence |
KEVCYERLGC
10 FSDDSPWSGI20 TERPLHILPW30 SPKDVNTRFL39 LYTNENPNNF49 QEVAADSSSI 59 SGSNFKTNRK69 TRFIIHGFID79 KGEENWLANV89 CKNLFKVESV99 NCICVDWKGG 109 SRTGYTQASQ119 NIRIVGAEVA129 YFVEFLQSAF139 GYSPSNVHVI149 GHSLGAHAAG 159 EAGRRTNGTI169 GRITGLDPAE179 PCFQGTPELV189 RLDPSDAKFV199 DVIHTDGAPI 209 VPNLGFGMSQ219 VVGHLDFFPN229 GGVEMPGCKK239 NILSQIVDID249 GIWEGTRDFA 259 ACNHLRSYKY269 YTDSIVNPDG279 FAGFPCASYN289 VFTANKCFPC299 PSGGCPQMGH 309 YADRYPGKTN319 DVGQKFYLDT329 GDASNFARWR339 YKVSVTLSGK349 KVTGHILVSL 359 FGNKGNSKQY369 EIFKGTLKPD379 STHSNEFDSD389 VDVGDLQMVK399 FIWYNNVINP 410 TLPRVGASKI420 IVETNVGKQF430 NFCSPETVRE440 EVLLTLTPC
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BNG or .BNG2 or .BNG3 or :3BNG;style chemicals stick;color identity;select .B:78 or .B:80 or .B:82 or .B:83 or .B:84 or .B:111 or .B:252; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| Ligand Name: Diundecyl Phosphatidyl Choline | Ligand Info | |||||
| Structure Description | INTERFACIAL ACTIVATION OF THE LIPASE-PROCOLIPASE COMPLEX BY MIXED MICELLES REVEALED BY X-RAY CRYSTALLOGRAPHY | PDB:1LPA | ||||
| Method | X-ray diffraction | Resolution | 3.04 Å | Mutation | No | [2] |
| PDB Sequence |
KEVCYERLGC
10 FSDDSPWSGI20 TERPLHILPW30 SPKDVNTRFL39 LYTNENPNNF49 QEVAADSSSI 59 SGSNFKTNRK69 TRFIIHGFID79 KGEENWLANV89 CKNLFKVESV99 NCICVDWKGG 109 SRTGYTQASQ119 NIRIVGAEVA129 YFVEFLQSAF139 GYSPSNVHVI149 GHSLGAHAAG 159 EAGRRTNGTI169 GRITGLDPAE179 PCFQGTPELV189 RLDPSDAKFV199 DVIHTDGAPI 209 VPNLGFGMSQ219 VVGHLDFFPN229 GGVEMPGCKK239 NILSQIVDID249 GIWEGTRDFA 259 ACNHLRSYKY269 YTDSIVNPDG279 FAGFPCASYN289 VFTANKCFPC299 PSGGCPQMGH 309 YADRYPGKTN319 DVGQKFYLDT329 GDASNFARWR339 YKVSVTLSGK349 KVTGHILVSL 359 FGNKGNSKQY369 EIFKGTLKPD379 STHSNEFDSD389 VDVGDLQMVK399 FIWYNNVINP 410 TLPRVGASKI420 IVETNVGKQF430 NFCSPETVRE440 EVLLTLTPC
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .PLC or .PLC2 or .PLC3 or :3PLC;style chemicals stick;color identity;select .B:76 or .B:77 or .B:78 or .B:79 or .B:114 or .B:151 or .B:152 or .B:153 or .B:178 or .B:180 or .B:209 or .B:213 or .B:215 or .B:252 or .B:255 or .B:256 or .B:259 or .B:260 or .B:263 or .B:264; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The 2.46 A resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. Biochemistry. 1995 Mar 7;34(9):2751-62. | ||||
| REF 2 | Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. Nature. 1993 Apr 29;362(6423):814-20. | ||||
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