Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97196 | Target Info | |||
| Target Name | ATM serine/threonine kinase (ATM) | ||||
| Synonyms | Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | ATM | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: AMP-PNP | Ligand Info | |||||
| Structure Description | Human ATM Dimer | PDB:7SIC | ||||
| Method | Electron microscopy | Resolution | 2.51 Å | Mutation | No | [1] |
| PDB Sequence |
LNDLLICCRQ
14 LEHDRATERK24 KEVEKFKRLI34 RDPETIKHLD44 NWDAVFRFLQ65 KYIQKETECQ 87 ASRQKKMQEI97 SSLVKYFIKC107 ANRRAPRLKC117 QELLNYIMDT127 VKDSSNGAIY 137 GADCSNILLK147 DILSVRKYWC157 EISQQQWLEL167 FSVYFRLYLK177 PSQDVHRVLV 187 ARIIHAVTKG197 CCSQTDGLNS207 KFLDFFSKAI217 QCARQEKSSS227 GLNHILAALT 237 IFLKTLAVNF247 RIRVCELGDE257 ILPTLLYIWT267 QHRLNDSLKE277 VIIELFQLQI 287 YIHHPKGAKT297 QEKGAYESTK307 WRSILYNLYD317 LLVNEISHIG327 SRRNIAVKEN 344 LIELMADICH354 QVFNIELGWE394 VIKDHLQKSQ404 NDFDLVPWLQ414 IATQLISKYP 424 ASLPNCELSP434 LLMILSQLLP444 QQRHGERTPY454 VLRCLTEVAL464 CQDKRSNLES 474 SQKSDLLKLW484 NKIWCITFRG494 ISSEQIQAEN504 FGLLGAIIQG514 SLVEVDREFW 524 KLFTGSACRP534 SCPAVCCLTL544 ALTTSIVPGT554 FSLKESIMKW579 LLFYQLETEV 595 PPILHSNFPH605 LVLEKILVSL615 TMKNCKAAMN625 FFQSVPECSF645 SEVEELFLQT 655 TFDKMDFLTG679 FSVHQNLKES689 LDRCLLGLSE699 QLLNNYSSEI709 TNSETLVRCS 719 RLLVGVLGCY729 CYMGVIAEEE739 AYKSELFQKA749 KSLMQCAGES759 ITLFKNKTNE 769 EFRIGSLRNM779 MQLCTRCLSN789 CTKKSPNKIA799 SGFFLRLLTS809 KLMNDIADIC 819 KSLASFISTI879 GAINPLAEEY889 LSKQDLLFLD899 MLKFLCLCVT909 TAQTNTVSFR 919 AADIRRKLLM929 LIDSSTLEPT939 KSLHLHMYLM949 LLKELPGEEY959 PLPMEDVLEL 969 LKPLSNVCSL979 YRRDQDVCKT989 ILNHVLHVVK999 NLGQSNMDSE1009 NTRDAQGQFL 1019 TVIGAFWHLT1029 KERKYIFSVR1039 MALVNCLKTL1049 LEADPYSKWA1059 ILNVMGKDFP 1069 VNEVFTQFLA1079 DNHHQVRMLA1089 AESINRLFQD1099 TKLKALPLKL1115 QQTAFENAYL 1125 KAQEGMREME1142 TLDEIYNRKS1152 VLLTLIAVVL1162 SCSPICEKQA1172 LFALCKSVKE 1182 NGLEPHLVKK1192 VLEKVSETFG1202 YRRLEDFMAS1212 HLDYLVLEWL1222 NLQDTEYNLS 1232 SFPFILLNYT1242 NIEDFYRSCY1252 KVLIPHLVIR1262 SHFDEVKSIA1272 NQIQEDWKSL 1282 LTDCFPKILV1292 NILPYFAYEG1302 TRDSGMAQQR1312 ETATKVYDML1322 KSENLLGKQI 1332 DHLFISNLPE1342 IVVELLMTLH1352 EPDLDPAPNP1378 PHFPSHVIKA1388 TFAYISNCHK 1398 TKLKSILEIL1408 SKSPDSYQKI1418 LLAICEQAAE1428 TNNVYKKHRI1438 LKIYHLFVSL 1448 LLKDIKSGLG1458 GAWAFVLRDV1468 IYTLIHYINQ1478 RPSCIMDVSL1488 RSFSLCCDLL 1498 SQVCQTAVTY1508 CKDALENHLH1518 VIVGTLIPLV1528 YEQVEVQKQV1538 LDLLKYLVID 1548 NKDNENLYIT1558 IKLLDPFPDH1568 VVFKDLRITQ1578 QKIKYSRGPF1588 SLLEEINHFL 1598 SVSVYDALPL1608 TRLEGLKDLR1618 RQLELHKDQM1628 VDIMRASQDN1638 PQDGIMVKLV 1648 VNLLQLSKMA1658 INHTGEKEVL1668 EAVGSCLGEV1678 GPIDFSTIAI1688 QHSKDASYTK 1698 ALKLFEDKEL1708 QWTFIMLTYL1718 NNTLVEDCVK1728 VRSAAVTCLK1738 NILATKTGHS 1748 FWEIYKMTTD1758 PMLAYLQPFR1768 TSRKKFLEVP1778 RFDKENPFEG1788 LDDINLWIPL 1798 SENHDIWIKT1808 LTCAFLDSGG1818 TKCEILQLLK1828 PMCEVKTDFC1838 QTVLPYLIHD 1848 ILLQDTNESW1858 RNLLSTHVQG1868 FFTSCLRHCC1900 LDKKSQRTML1910 AVVDYMRRQK 1920 RPSSGTIFND1930 AFWLDLNYLE1940 VAKVAQSCAA1950 HFTALLYAEI1960 YADKKSMDDQ 1970 EKRSTTISSL1989 SEKSKEETGI1999 SLQDLLLEIY2009 RSIGEPDSLY2019 GCGGGKMLQP 2029 ITRLRTYEHE2039 AMWGKALVTY2049 DLETAIPSST2059 RQAGIIQALQ2069 NLGLCHILSV 2079 YLKGLDYENK2089 DWCPELEELH2099 YQAAWRNMQW2109 DHCGTSYHES2127 LYNALQSLRD 2137 REFSTFYESL2147 KYARVKEVEE2157 MCKRSLESVY2167 SLYPTLSRLQ2177 AIGELESIGE 2187 LFSRSVTHRQ2197 LSEVYIKWQK2207 HSQLLKDSDF2217 SFQEPIMALR2227 TVILEILMEK 2237 EMDNSQRECI2247 KDILTKHLVE2257 LSILARTFKN2267 TQLPERAIFQ2277 IKQYNSVSCG 2287 VSEWQLEEAQ2297 VFWAKKEQSL2307 ALSILKQMIK2317 KLDASCAANN2327 PSLKLTYTEC 2337 LRVCGNWLAE2347 TCLENPAVIM2357 QTYLEKAVEV2367 AGNYDGESSD2377 ELRNGKMKAF 2387 LSLARFSDTQ2397 YQRIENYMKS2407 SEFENKQALL2417 KRAKERYTVK2440 VQRELELDEL 2450 ALRALKEDRK2460 RFLCKAVENY2470 INCLLSGEEH2480 DMWVFRLCSL2490 WLENSGVSEV 2500 NGMMKRDGMK2510 IPTYKFLPLM2520 YQLAARMGTK2530 MMGGLGFHEV2540 LNNLISRISM 2550 DHPHHTLFII2560 LALANANRDE2570 FLTSSQLDED2597 RTEAANRIIC2607 TIRSRRPQMV 2617 RSVEALCDAY2627 IILANLDATQ2637 WKTQRKGINI2647 PADQPITKLK2657 NLEDVVVPTM 2667 EIKVDHTGEY2677 GNLVTIQSFK2687 AEFRLAGGVN2697 LPKIIDCVGS2707 DGKERRQLVK 2717 GRDDLRQDAV2727 MQQVFQMCNT2737 LLQRNTETRK2747 RKLTICTYKV2757 VPLSQRSGVL 2767 EWCTGTVPIG2777 EFLVNNEDGA2787 HKRYRPNDFS2797 AFQCQKKMME2807 VQKKSFEEKY 2817 EVFMDVCQNF2827 QPVFRYFCME2837 KFLDPAIWFE2847 KRLAYTRSVA2857 TSSIVGYILG 2867 LGDRHVQNIL2877 INEQSAELVH2887 IDLGVAFEQG2897 KILPTPETVP2907 FRLTRDIVDG 2917 MGITGVEGVF2927 RRCCEKTMEV2937 MRNSQETLLT2947 IVEVLLYDPL2957 FDWTMNPLKA 2967 LYLQQRPSFN3003 KVAERVLMRL3013 QEKLKGVEEG3023 TVLSVGGQVN3033 LLIQQAIDPK 3043 NLSRLFPGWK3053 AWV
|
|||||
|
|
ALA2693
4.239
GLY2694
3.436
GLY2695
4.218
VAL2696
4.171
ASN2697
4.069
PRO2699
4.858
LEU2715
3.786
LYS2717
3.014
ASP2720
4.489
TYR2755
3.901
LEU2767
3.356
|
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: KU-55933 | Ligand Info | |||||
| Structure Description | Human ATM kinase with bound inhibitor KU-55933 | PDB:7NI5 | ||||
| Method | Electron microscopy | Resolution | 2.78 Å | Mutation | No | [2] |
| PDB Sequence |
LVLNDLLICC
12 RQLEHDRATE22 RKKEVEKFKR32 LIRDPETIKH42 LDRHSDSKQG52 KYLNWDAVFR 62 FLQKYIQKET72 ECLRIASTQA88 SRQKKMQEIS98 SLVKYFIKCA108 NRRAPRLKCQ 118 ELLNYIMDTV128 KDSSNGAIYG138 ADCSNILLKD148 ILSVRKYWCE158 ISQQQWLELF 168 SVYFRLYLKP178 SQDVHRVLVA188 RIIHAVTKGC198 CSQTDGLNSK208 FLDFFSKAIQ 218 CARQEKSSSG228 LNHILAALTI238 FLKTLAVNFR248 IRVCELGDEI258 LPTLLYIWTQ 268 HRLNDSLKEV278 IIELFQLQIY288 IHHPKGAKTQ298 EKGAYESTKW308 RSILYNLYDL 318 LVNEISHIGS328 RGKYSSGFRN338 IAVKENLIEL348 MADICHQVFI389 ELGWEVIKDH 399 LQKSQNDFDL409 VPWLQIATQL419 ISKYPASLPN429 CELSPLLMIL439 SQLLPQQRHG 449 ERTPYVLRCL459 TEVALCQDKR469 SNLESSQKSD479 LLKLWNKIWC489 ITFRGISSEQ 499 IQAENFGLLG509 AIIQGSLVEV519 DREFWKLFTG529 SACRPSCPAV539 CCLTLALTTS 549 IVPGTFSLKE574 SIMKWLLFYQ584 EVPPILHSNF603 PHLVLEKILV613 SLTMKNCKAA 623 MNFFQSVPEC633 EHHQKDKEEL643 SFSEVEELFL653 QTTFDKMDFL663 TSSIGFSVHQ 684 NLKESLDRCL694 LGLSEQLLNN704 YSSEITNSET714 LVRCSRLLVG724 VLGCYCYMGV 734 IAEEEAYKSE744 LFQKAKSLMQ754 CAGESITLFK764 NKTNEEFRIG774 SLRNMMQLCT 784 RCLSNCTKKS794 PNKIASGFFL804 RLLTSKLMND814 IADICKSLAS824 FIKKIGAINP 884 LAEEYLSKQD894 LLFLDMLKFL904 CLCVTTAQTN914 TVSFRAADIR924 RKLLMLIDSS 934 TLEPTKSLHL944 HMYLMLLKEL954 PGEEYPLPME964 DVLELLKPLS974 NVCSLYRRDQ 984 DVCKTILNHV994 LHVVKNLGQS1004 NMDSENTRDA1014 QGQFLTVIGA1024 FWHLTKERKY 1034 IFSVRMALVN1044 CLKTLLEADP1054 YSKWAILNVM1064 GKDFPVNEVF1074 TQFLADNHHQ 1084 VRMLAAESIN1094 RLFQDTLLKA1110 LPLKLQQTAF1120 ENAYLKAQEG1130 MREMSHSAEN 1140 PETLDEIYNR1150 KSVLLTLIAV1160 VLSCSPICEK1170 QALFALCKSV1180 KENGLEPHLV 1190 KKVLEKVSET1200 FGYRRLEDFM1210 ASHLDYLVLE1220 WLNLQDTEYN1230 LSSFPFILLN 1240 YTNIEDFYRS1250 CYKVLIPHLV1260 IRSHFDEVKS1270 IANQIQEDWK1280 SLLTDCFPKI 1290 LVNILPYFAY1300 EGTRDSGMAQ1310 QRETATKVYD1320 MLKSENLLGK1330 QIDHLFISNL 1340 PEIVVELLMT1350 LHEPDLDPAP1376 NPPHFPSHVI1386 KATFAYISNC1396 ILEILSKSPD 1413 SYQKILLAIC1423 EQAAETNNVY1433 KKHRILKIYH1443 LFVSLLLKDI1453 KSGLGGAWAF 1463 VLRDVIYTLI1473 HYINQRPSCI1483 MDVSLRSFSL1493 CCDLLSQVCQ1503 TAVTYCKDAL 1513 ENHLHVIVGT1523 LIPLVYEQVE1533 VQKQVLDLLK1543 YLVIDNKDNE1553 NLYITIKLLD 1563 PFPDHVVFKD1573 LRITQQKIKY1583 SRGPFSLLEE1593 INHFLSVSVY1603 DALPLTRLEG 1613 LKDLRRQLEL1623 HKDQMVDIMR1633 ASQDNPQDGI1643 MVKLVVNLLQ1653 LSKMAINHTG 1663 EKEVLEAVGS1673 CLGEVGPIDF1683 STIAIQHSKD1693 ASYTKALKLF1703 EDKELQWTFI 1713 MLTYLNNTLV1723 EDCVKVRSAA1733 VTCLKNILAT1743 KTGHSFWEIY1753 KMTTDPMLAY 1763 LQPFRTSRKK1773 FLEVPRFDKE1783 NPFEGLDDIN1793 LWIPLSENHD1803 IWIKTLTCAF 1813 LDSGGTKCEI1823 LQLLKPMCEV1833 KTDFCQTVLP1843 YLIHDILLQD1853 TNESWRNLLS 1863 THVQGFFTSC1873 LRHHFFRCCL1901 DKKSQRTMLA1911 VVDYMRRQKR1921 PSSGTIFNDA 1931 FWLDLNYLEV1941 AKVAQSCAAH1951 FTALLYAEIY1961 ADKKSMDDQE1971 KISSLSEKSK 1994 EETGISLQDL2004 LLEIYRSIGE2014 PDSLYGCGGG2024 KMLQPITRLR2034 TYEHEAMWGK 2044 ALVTYDLETA2054 IPSSTRQAGI2064 IQALQNLGLC2074 HILSVYLKGL2084 DYENKDWCPE 2094 LEELHYQAAW2104 RNMQWDHCGT2122 SYHESLYNAL2132 QSLRDREFST2142 FYESLKYARV 2152 KEVEEMCKRS2162 LESVYSLYPT2172 LSRLQAIGEL2182 ESIGELFSRS2192 VTHRQLSEVY 2202 IKWQKHSQLL2212 KDSDFSFQEP2222 IMALRTVILE2232 ILMEKEMDNS2242 QRECIKDILT 2252 KHLVELSILA2262 RTFKNTQLPE2272 RAIFQIKQYN2282 SVSCGVSEWQ2292 LEEAQVFWAK 2302 KEQSLALSIL2312 KQMIKKLDAS2322 CAANNPSLKL2332 TYTECLRVCG2342 NWLAETCLEN 2352 PAVIMQTYLE2362 KAVEVASDEL2379 RNGKMKAFLS2389 LARFSDTQYQ2399 RIENYMKSSE 2409 FENKQALLKR2419 QRELELDELA2451 LRALKEDRKR2461 FLCKAVENYI2471 NCLLSGEEHD 2481 MWVFRLCSLW2491 LENSGVSEVN2501 GMMKRDGMKI2511 PTYKFLPLMY2521 QLAARMGTKM 2531 MGGLGFHEVL2541 NNLISRISMD2551 HPHHTLFIIL2561 ALANANRDEF2571 LTKSQLDEDR 2598 TEAANRIICT2608 IRSRRPQMVR2618 SVEALCDAYI2628 ILANLDATQW2638 KTQRKGINIP 2648 ADQPITKLKN2658 LEDVVVPTME2668 IKVDHTGEYG2678 NLVTIQSFKA2688 EFRLAGGVNL 2698 PKIIDCVGSD2708 GKERRQLVKG2718 RDDLRQDAVM2728 QQVFQMCNTL2738 LQRNTETRKR 2748 KLTICTYKVV2758 PLSQRSGVLE2768 WCTGTVPIGE2778 FLVNNEDGAH2788 KRYRPNDFSA 2798 FQCQKKMMEV2808 QKKSFEEKYE2818 VFMDVCQNFQ2828 PVFRYFCMEK2838 FLDPAIWFEK 2848 RLAYTRSVAT2858 SSIVGYILGL2868 GDRHVQNILI2878 NEQSAELVHI2888 DLGVAFEQGK 2898 ILPTPETVPF2908 RLTRDIVDGM2918 GITGVEGVFR2928 RCCEKTMEVM2938 RNSQETLLTI 2948 VEVLLYDPLF2958 DWTMNPLKAL2968 YLQQQSFNKV3005 AERVLMRLQE3015 KLKGVEEGTV 3025 LSVGGQVNLL3035 IQQAIDPKNL3045 SRLFPGWKAW3055 V
|
|||||
|
|
ALA2693
3.772
GLY2694
4.223
GLY2695
4.235
PRO2699
3.548
LEU2715
3.906
LYS2717
3.454
ASP2725
4.126
TYR2755
3.824
LEU2767
3.765
GLU2768
3.594
|
|||||
| Ligand Name: ATM Inhibitor-5 | Ligand Info | |||||
| Structure Description | Human ATM kinase domain with bound M4076 inhibitor | PDB:7NI4 | ||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | No | [2] |
| PDB Sequence |
LENHLHVIVG
1522 TLIPLVYEQV1532 EVQKQVLDLL1542 KYLVIDNKDN1552 ENLYITIKLL1562 DPFPDHVVFK 1572 DLRITQQKIK1582 YSRGPFSLLE1592 EINHFLSVSV1602 YDALPLTRLE1612 GLKDLRRQLE 1622 LHKDQMVDIM1632 RASQDNPQDG1642 IMVKLVVNLL1652 QLSKMAINHT1662 GEKEVLEAVG 1672 SCLGEVGPID1682 FSTIAIQHSK1692 DASYTKALKL1702 FEDKELQWTF1712 IMLTYLNNTL 1722 VEDCVKVRSA1732 AVTCLKNILA1742 TKTGHSFWEI1752 YKMTTDPMLA1762 YLQPFRTSRK 1772 KFLEVPRFDK1782 ENPFEGLDDI1792 NLWIPLSENH1802 DIWIKTLTCA1812 FLDSGGTKCE 1822 ILQLLKPMCE1832 VKTDFCQTVL1842 PYLIHDILLQ1852 DTNESWRNLL1862 STHVQGFFTS 1872 CLRHHFFRCC1900 LDKKSQRTML1910 AVVDYMRRQK1920 RPSSGTIFND1930 AFWLDLNYLE 1940 VAKVAQSCAA1950 HFTALLYAEI1960 YADKKSMDDQ1970 EKISSLSEKS1993 KEETGISLQD 2003 LLLEIYRSIG2013 EPDSLYGCGG2023 GKMLQPITRL2033 RTYEHEAMWG2043 KALVTYDLET 2053 AIPSSTRQAG2063 IIQALQNLGL2073 CHILSVYLKG2083 LDYENKDWCP2093 ELEELHYQAA 2103 WRNMQWDHCG2121 TSYHESLYNA2131 LQSLRDREFS2141 TFYESLKYAR2151 VKEVEEMCKR 2161 SLESVYSLYP2171 TLSRLQAIGE2181 LESIGELFSR2191 SVTHRQLSEV2201 YIKWQKHSQL 2211 LKDSDFSFQE2221 PIMALRTVIL2231 EILMEKEMDN2241 SQRECIKDIL2251 TKHLVELSIL 2261 ARTFKNTQLP2271 ERAIFQIKQY2281 NSVSCGVSEW2291 QLEEAQVFWA2301 KKEQSLALSI 2311 LKQMIKKLDA2321 SCAANNPSLK2331 LTYTECLRVC2341 GNWLAETCLE2351 NPAVIMQTYL 2361 EKAVEVASDE2378 LRNGKMKAFL2388 SLARFSDTQY2398 QRIENYMKSS2408 EFENKQALLK 2418 RQRELELDEL2450 ALRALKEDRK2460 RFLCKAVENY2470 INCLLSGEEH2480 DMWVFRLCSL 2490 WLENSGVSEV2500 NGMMKRDGMK2510 IPTYKFLPLM2520 YQLAARMGTK2530 MMGGLGFHEV 2540 LNNLISRISM2550 DHPHHTLFII2560 LALANANRDE2570 FLTKSQLDED2597 RTEAANRIIC 2607 TIRSRRPQMV2617 RSVEALCDAY2627 IILANLDATQ2637 WKTQRKGINI2647 PADQPITKLK 2657 NLEDVVVPTM2667 EIKVDHTGEY2677 GNLVTIQSFK2687 AEFRLAGGVN2697 LPKIIDCVGS 2707 DGKERRQLVK2717 GRDDLRQDAV2727 MQQVFQMCNT2737 LLQRNTETRK2747 RKLTICTYKV 2757 VPLSQRSGVL2767 EWCTGTVPIG2777 EFLVNNEDGA2787 HKRYRPNDFS2797 AFQCQKKMME 2807 VQKKSFEEKY2817 EVFMDVCQNF2827 QPVFRYFCME2837 KFLDPAIWFE2847 KRLAYTRSVA 2857 TSSIVGYILG2867 LGDRHVQNIL2877 INEQSAELVH2887 IDLGVAFEQG2897 KILPTPETVP 2907 FRLTRDIVDG2917 MGITGVEGVF2927 RRCCEKTMEV2937 MRNSQETLLT2947 IVEVLLYDPL 2957 FDWTMNPLKA2967 LYLQQQSFNK3004 VAERVLMRLQ3014 EKLKGVEEGT3024 VLSVGGQVNL 3034 LIQQAIDPKN3044 LSRLFPGWKA3054 WV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .UGK or .UGK2 or .UGK3 or :3UGK;style chemicals stick;color identity;select .A:2693 or .A:2694 or .A:2695 or .A:2699 or .A:2701 or .A:2715 or .A:2717 or .A:2722 or .A:2725 or .A:2755 or .A:2767 or .A:2768 or .A:2769 or .A:2770 or .A:2773 or .A:2774 or .A:2775 or .A:2874 or .A:2877 or .A:2888 or .A:2889; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA2693
3.440
GLY2694
3.519
GLY2695
4.638
PRO2699
3.857
ILE2701
4.980
LEU2715
3.577
LYS2717
2.774
LEU2722
4.877
ASP2725
3.502
TYR2755
3.402
LEU2767
3.111
|
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| Ligand Name: Phosphothiophosphoric acid-adenylate ester | Ligand Info | |||||
| Structure Description | Human ATM kinase with bound ATPyS | PDB:7NI6 | ||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
HLHVIVGTLI
1525 PLVYEQVEVQ1535 KQVLDLLKYL1545 VIDNKDNENL1555 YITIKLLDPF1565 PDHVVFKDLR 1575 ITQQKIKYSR1585 GPFSLLEEIN1595 HFLSVSVYDA1605 LPLTRLEGLK1615 DLRRQLELHK 1625 DQMVDIMRAS1635 QDNPQDGIMV1645 KLVVNLLQLS1655 KMAINHTGEK1665 EVLEAVGSCL 1675 GEVGPIDFST1685 IAIQHSKDAS1695 YTKALKLFED1705 KELQWTFIML1715 TYLNNTLVED 1725 CVKVRSAAVT1735 CLKNILATKT1745 GHSFWEIYKM1755 TTDPMLAYLQ1765 PFRTSRKKFL 1775 EVPRFDKENP1785 FEGLDDINLW1795 IPLSENHDIW1805 IKTLTCAFLD1815 SGGTKCEILQ 1825 LLKPMCEVKT1835 DFCQTVLPYL1845 IHDILLQDTN1855 ESWRNLLSTH1865 VQGFFTSCLR 1875 HHFFRCCLDK1903 KSQRTMLAVV1913 DYMRRQKRPS1923 SGTIFNDAFW1933 LDLNYLEVAK 1943 VAQSCAAHFT1953 ALLYAEIYAD1963 KKSMDDQEKI1986 SSLSEKSKEE1996 TGISLQDLLL 2006 EIYRSIGEPD2016 SLYGCGGGKM2026 LQPITRLRTY2036 EHEAMWGKAL2046 VTYDLETAIP 2056 SSTRQAGIIQ2066 ALQNLGLCHI2076 LSVYLKGLDY2086 CPELEELHYQ2101 AAWRNMQWDH 2111 CGTSYHESLY2129 NALQSLRDRE2139 FSTFYESLKY2149 ARVKEVEEMC2159 KRSLESVYSL 2169 YPTLSRLQAI2179 GELESIGELF2189 SRSVTHRQLS2199 EVYIKWQKHS2209 QLLKDSDFSF 2219 QEPIMALRTV2229 ILEILMEKEM2239 DNSQRECIKD2249 ILTKHLVELS2259 ILARTFKNTQ 2269 LPERAIFQIK2279 QYNSVSCGVS2289 EWQLEEAQVF2299 WAKKEQSLAL2309 SILKQMIKKL 2319 DASCAANNPS2329 LKLTYTECLR2339 VCGNWLAETC2349 LENPAVIMQT2359 YLEKAVEVAS 2376 DELRNGKMKA2386 FLSLARFSDT2396 QYQRIENYMK2406 SSEFENKQAL2416 LKRQRELELD 2448 ELALRALKED2458 RKRFLCKAVE2468 NYINCLLSGE2478 EHDMWVFRLC2488 SLWLENSGVS 2498 EVNGMMKRDG2508 MKIPTYKFLP2518 LMYQLAARMG2528 TKMMGGLGFH2538 EVLNNLISRI 2548 SMDHPHHTLF2558 IILALANANR2568 DEFLTKSQLD2595 EDRTEAANRI2605 ICTIRSRRPQ 2615 MVRSVEALCD2625 AYIILANLDA2635 TQWKTQRKGI2645 NIPADQPITK2655 LKNLEDVVVP 2665 TMEIKVDHTG2675 EYGNLVTIQS2685 FKAEFRLAGG2695 VNLPKIIDCV2705 GSDGKERRQL 2715 VKGRDDLRQD2725 AVMQQVFQMC2735 NTLLQRNTET2745 RKRKLTICTY2755 KVVPLSQRSG 2765 VLEWCTGTVP2775 IGEFLVNNED2785 GAHKRYRPND2795 FSAFQCQKKM2805 MEVQKKSFEE 2815 KYEVFMDVCQ2825 NFQPVFRYFC2835 MEKFLDPAIW2845 FEKRLAYTRS2855 VATSSIVGYI 2865 LGLGDRHVQN2875 ILINEQSAEL2885 VHIDLGVAFE2895 QGKILPTPET2905 VPFRLTRDIV 2915 DGMGITGVEG2925 VFRRCCEKTM2935 EVMRNSQETL2945 LTIVEVLLYD2955 PLFDWTMNPL 2965 KALYLQQQSF3002 NKVAERVLMR3012 LQEKLKGVEE3022 GTVLSVGGQV3032 NLLIQQAIDP 3042 KNLSRLFPGW3052 KAWV
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AGS or .AGS2 or .AGS3 or :3AGS;style chemicals stick;color identity;select .A:2693 or .A:2694 or .A:2695 or .A:2696 or .A:2697 or .A:2699 or .A:2715 or .A:2717 or .A:2720 or .A:2755 or .A:2767 or .A:2768 or .A:2769 or .A:2770 or .A:2773 or .A:2775 or .A:2874 or .A:2875 or .A:2877 or .A:2888 or .A:2889 or .A:2969; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ALA2693
3.332
GLY2694
3.780
GLY2695
3.618
VAL2696
4.181
ASN2697
4.549
PRO2699
4.286
LEU2715
3.585
LYS2717
2.363
ASP2720
4.652
TYR2755
3.943
LEU2767
3.595
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife. 2022 Jan 25;11:e74218. | ||||
| REF 2 | Molecular basis of human ATM kinase inhibition. Nat Struct Mol Biol. 2021 Oct;28(10):789-798. | ||||
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