Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T98395 Target Info
Target Name PPAR-gamma coactivator 1-beta (PPARGC1B)
Synonyms Peroxisome proliferator-activated receptor gamma coactivator 1-beta; PPARGC1; PPARGC-1-beta; PGC1B; PGC1; PGC-1-related estrogen receptor alpha coactivator; PGC-1-beta; PERC
Target Type Literature-reported Target
Gene Name PPARGC1B
Biochemical Class RNA recognition motif
UniProt ID
PRGC2_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 3-iodotyrosine Ligand Info
Structure Description X-ray Crystal Structure of PGC-1beta C-terminus bound to the CBP80-CBP20 Cap Binding Complex PDB:6D0Y
Method X-ray diffraction Resolution 2.68 Å Mutation No [1]
PDB Sequence
SKEAMDFDSL
11
LKEAQQSL
Residue
Distance (Å)
SER1
3.277
LYS2
1.328
GLU4
1.329
ALA5
3.035
Residue
Distance (Å)
MET6
3.098
LEU11
2.566
GLU14
4.033
References  Top
REF 1 Transcriptional coactivator PGC-1Alpha contains a novel CBP80-binding motif that orchestrates efficient target gene expression. Genes Dev. 2018 Apr 1;32(7-8):555-567.

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