Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00938 | Target Info | |||
| Target Name | Melanoma antigen gp75 (TYRP1) | ||||
| Synonyms | Tyrosinaserelated protein 1; TYRP1; TRP; Glycoprotein 75; Catalase B; 5,6dihydroxyindole2carboxylic acid oxidase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TYRP1 | ||||
| Biochemical Class | Tyrosinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Tropolone | Ligand Info | |||
| Canonical SMILES | C1=CC=C(C(=O)C=C1)O | ||||
| InChI | 1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9) | ||||
| InChIKey | MDYOLVRUBBJPFM-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 10789 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5M8T Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone | ||||||
| Method | X-ray diffraction | Resolution | 2.35 Å | Mutation | Yes | [1] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGFSD364 PTGKYDPAVS374 SLHNLAHLFL 384 NGTGGQVHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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| PDB ID: 5M8O Crystal structure of human tyrosinase related protein 1 in complex with tropolone | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [1] |
| PDB Sequence |
QFPRQCATVE
34 ALRSGMCCPD44 LSPVSGPGTD54 RCGSSSGRGR64 CEAVTADSRP74 HSPQYPHDGR 84 DDREVWPLRF94 FNRTCHCNGN104 FSGHNCGTCR114 PGWRGAACDQ124 RVLIVRRNLL 134 DLSKEEKNHF144 VRALDMAKRT154 THPLFVIATR164 RSEEILGPDG174 NTPQFENISI 184 YNYFVWTHYY194 SVKKTFLGVG204 QESFGEVDFS214 HEGPAFLTWH224 RYHLLRLEKD 234 MQEMLQEPSF244 SLPYWNFATG254 KNVCDICTDD264 LMGSRSNFDS274 TLISPNSVFS 284 QWRVVCDSLE294 DYDTLGTLCN304 STEDGPIRRN314 PAGNVARPMV324 QRLPEPQDVA 334 QCLEVGLFDT344 PPFYSNSTNS354 FRNTVEGYSD364 PTGKYDPAVR374 SLHNLAHLFL 384 NGTGGQTHLS394 PNDPIFVLLH404 TFTDAVFDEW414 LRRYNADIST424 FPLENAPIGH 434 NRQYNMVPFW444 PPVTNTEMFV454 TAPDNLGYTY464 EIQWPS
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of Human Tyrosinase Related Protein?1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9812-9815. | ||||
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