Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01725 | Target Info | |||
| Target Name | Protein-cysteine N-palmitoyltransferase HHAT (HHAT) | ||||
| Synonyms | Skinny hedgehog protein 1; Melanoma antigen recognized by T-cells 2; MART-2; Hedgehog acyltransferase; HHAT | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | HHAT | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C | ||||
| InChI | 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 | ||||
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N | ||||
| PubChem Compound ID | 5997 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7Q1U Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map) | ||||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
MLPRWELALY
10 LLASLGFHFY20 SFYEVYKVSR30 EHEEELDQEF40 ELETDTLFGG50 LKKDATDFEW 60 SFWMEWGKQW70 LVWLLLGHMV80 VSQMATLLAR90 KHRPWILMLY100 GMWACWCVLG 110 TPGVAMVLLH120 TTISFCVAQF130 RSQLLTWLCS140 LLLLSTLRLQ150 GVEEVKRRWY 160 KTENEYYLLQ170 FTLTVRCLYY180 TNFSLELCTS198 YSFPWMLAYV208 FYYPVLHNGP 218 ILSFSEFIKQ228 MQQQEHDSLK238 ASLCVLALGL248 GRLLCWWWLA258 ELMAHLMYMH 268 AIYSSIPLLE278 TVSCWTLGGL288 ALAQVLFFYV298 KYLVLFGVPA308 LLMRLDGLTP 318 PALPRCVSTM328 FSFTGMWRYF338 DVGLHNFLIR348 YVYIPVGGSQ358 HGLLGTLFST 368 AMTFAFVSYW378 HGGYDYLWWA389 ALNWLGVTVE399 NGVRRLVETP409 CIQDSLARYF 419 SPQARRRFHA429 ALASCSTSML439 ILSNLVFLGG449 NEVGKTYWNR459 IFIQGWPWVT 469 LSVLGFLYCY479 SHVGIAWAQT489 YATD
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| PDB ID: 7Q6Z Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575 | ||||||
| Method | Electron microscopy | Resolution | 3.59 Å | Mutation | No | [1] |
| PDB Sequence |
MLPRWELALY
10 LLASLGFHFY20 SFYEVYKVSR30 EHEEELDQEF40 ELETDTLFGG50 LKKDATDFEW 60 SFWMEWGKQW70 LVWLLLGHMV80 VSQMATLLAR90 KHRPWILMLY100 GMWACWCVLG 110 TPGVAMVLLH120 TTISFCVAQF130 RSQLLTWLCS140 LLLLSTLRLQ150 GVEEVKRRWY 160 KTENEYYLLQ170 FTLTVRCLYY180 TNFSLELCTS198 YSFPWMLAYV208 FYYPVLHNGP 218 ILSFSEFIKQ228 MQQQEHDSLK238 ASLCVLALGL248 GRLLCWWWLA258 ELMAHLMYMH 268 AIYSSIPLLE278 TVSCWTLGGL288 ALAQVLFFYV298 KYLVLFGVPA308 LLMRLDGLTP 318 PALPRCVSTM328 FSFTGMWRYF338 DVGLHNFLIR348 YVYIPVGGSQ358 HGLLGTLFST 368 AMTFAFVSYW378 HGGYDYLWCW388 AALNWLGVTV398 ENGVRRLVET408 PCIQDSLARY 418 FSPQARRRFH428 AALASCSTSM438 LILSNLVFLG448 GNEVGKTYWN458 RIFIQGWPWV 468 TLSVLGFLYC478 YSHVGIAWAQ488 TYATD
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure, mechanism, and inhibition of Hedgehog acyltransferase. Mol Cell. 2021 Dec 16;81(24):5025-5038.e10. | ||||
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