Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T07400 | Target Info | |||
| Target Name | Advanced glycosylation end product receptor (AGER) | ||||
| Synonyms | Receptor foradvanced glycosylation end products; RAGESEC; RAGE; AGER | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | AGER | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 7-methyl-3-phenyl-1H-indole-2-carboxylic acid | Ligand Info | |||
| Canonical SMILES | CC1=C2C(=CC=C1)C(=C(N2)C(=O)O)C3=CC=CC=C3 | ||||
| InChI | 1S/C16H13NO2/c1-10-6-5-9-12-13(11-7-3-2-4-8-11)15(16(18)19)17-14(10)12/h2-9,17H,1H3,(H,18,19) | ||||
| InChIKey | OSOLISRTJWBBIW-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 16645886 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6XQ5 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragment 1 | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
GAMAQNITAR
29 IGEPLVLKCK39 GAPKKPPQRL49 EWKLNTGRTE59 AWKVLSPQGG69 GPWDSVARVL 79 PNGSLFLPAV89 GIQDEGIFRC99 QAMNRNGKET109 KSNYRVRVYQ119 IPGKPEIVDS 129 ASELTAGVPN139 KVGTCVSEGS149 YPAGTLSWHL159 DGKPLVPNEK169 GVSVKEQTRR 179 HPETGLFTLQ189 SELMVTPARG199 GDPRPTFSCS209 FSPGLPRHRA219 LRTAPIQPRV 229 WE
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| PDB ID: 6XQ8 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 11 | ||||||
| Method | X-ray diffraction | Resolution | 1.82 Å | Mutation | No | [1] |
| PDB Sequence |
GAMAQNITAR
29 IGEPLVLKCK39 GAPKKPPQRL49 EWKLNTGRTE59 AWKVLSPQGG69 GPWDSVARVL 79 PNGSLFLPAV89 GIQDEGIFRC99 QAMNRNGKET109 KSNYRVRVYQ119 IPGKPEIVDS 129 ASELTAGVPN139 KVGTCVSEGS149 YPAGTLSWHL159 DGKPLVPNEK169 GVSVKEQTRR 179 HPETGLFTLQ189 SELMVTPARG199 GDPRPTFSCS209 FSPLRTAPIQ226 PRVWE |
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| PDB ID: 6XQ9 Receptor for Advanced Glycation End Products VC1 domain in complex with Fragments 1 & 13 | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [1] |
| PDB Sequence |
GAMAQNITAR
29 IGEPLVLKCK39 GAPKKPPQRL49 EWKLNTGRTE59 AWKVLSPQGG69 GPWDSVARVL 79 PNGSLFLPAV89 GIQDEGIFRC99 QAMNRNGKET109 KSNYRVRVYQ119 IPGKPEIVDS 129 ASELTAGVPN139 KVGTCVSEGS149 YPAGTLSWHL159 DGKPLVPNEK169 GVSVKEQTRR 179 HPETGLFTLQ189 SELMVTPARG199 GDPRPTFSCS209 FSPGLPRHRA219 LRTAPIQPRV 229 WE
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A fragment-based approach to discovery of Receptor for Advanced Glycation End products inhibitors. Proteins. 2021 Nov;89(11):1399-1412. | ||||
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