Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T19334 | Target Info | |||
Target Name | Interleukin 21 receptor (IL21R) | ||||
Synonyms | UNQ3121/PRO10273; Novel interleukin receptor; NILR; Interleukin-21 receptor; IL21 receptor; IL-21R; IL-21 receptor; CD360 | ||||
Target Type | Clinical trial Target | ||||
Gene Name | IL21R | ||||
Biochemical Class | Cytokine receptor | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | Alpha-D-Mannose | Ligand Info | |||
Canonical SMILES | C(C1C(C(C(C(O1)O)O)O)O)O | ||||
InChI | 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1 | ||||
InChIKey | WQZGKKKJIJFFOK-PQMKYFCFSA-N | ||||
PubChem Compound ID | 185698 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 4NZD Interleukin 21 receptor | ||||||
Method | X-ray diffraction | Resolution | 2.75 Å | Mutation | No | [1] |
PDB Sequence |
CPDLVCYTDY
10 LQTVICILEM20 WNLHPSTLTL30 TWQEATSCSL48 HRSAHNATHA58 TYTCHMDVFH 68 FMADDIFSVQ78 ITDQSGQYSQ88 ECGSFLLAES98 IKPAPPFDVT108 VTFSGQYQIS 118 WRSDYEDPAF128 YMLKGKLQYE138 LQYRNRGDPW148 AVSPRRKLIS158 VDSRSVSLLP 168 LEFRKDSSYE178 LQVRAGPMPG188 SSYQGTWSEW198 SDPVIFQTQS208 EELKEHHHHH 218
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PDB ID: 3TGX IL-21:IL21R complex | ||||||
Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | Yes | [2] |
PDB Sequence |
CPDLVCYTDY
10 LQTVICILEM20 WNLHPSTLTL30 TWQDQYEELK40 DEATSCSLHR50 SAHNATHATY 60 TCHMDVFHFM70 ADDIFSVQIT80 DQSGQYSQEC90 GSFLLAESIK100 PAPPFDVTVT 110 FSGQYQISWR120 SDYEDPAFYM130 LKGKLQYELQ140 YRNRGDPWAV150 SPRRKLISVD 160 SRSVSLLPLE170 FRKDSSYELQ180 VRAGPMPGSS190 YQGTWSEWSD200 PVIFQTQS |
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PDB ID: 6PLH FAB fragment complexed with C-mannosylated tryptophan peptide | ||||||
Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [3] |
PDB Sequence |
TWSEWSDP
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References | Top | ||||
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REF 1 | Interleukin 21 receptor structure and function | ||||
REF 2 | Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J Biol Chem. 2012 Mar 16;287(12):9454-60. | ||||
REF 3 | Yeast- and antibody-based tools for studying tryptophan C-mannosylation. Nat Chem Biol. 2021 Apr;17(4):428-437. |
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