Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23984 | Target Info | |||
| Target Name | Bromodomain-containing protein 7 (BRD7) | ||||
| Synonyms | Protein CELTIX-1; CELTIX1; BP75; 75 kDa bromodomain protein | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BRD7 | ||||
| Biochemical Class | Bromodomain | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One | Ligand Info | |||
| Canonical SMILES | CN1C=C(C2=C(C1=O)C=NC=C2)C3=C(C=C(C(=C3)OC)CN(C)C)OC | ||||
| InChI | 1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10,12H,11H2,1-5H3 | ||||
| InChIKey | BJFSUDWKXGMUKA-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 117072549 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6V1F Crystal structure of the bromodomain of human BRD7 bound to BI9564 | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [1] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQSLK 241 QSIDFMA
|
|||||
|
|
||||||
| PDB ID: 5MQ1 Crystal structure of the BRD7 bromodomain in complex with BI-9564 | ||||||
| Method | X-ray diffraction | Resolution | 1.50 Å | Mutation | No | [2] |
| PDB Sequence |
EQTPLQEALN
141 QLMRQLQRKD151 PSAFFSFPVT161 DFIAPGYSMI171 IKHPMDFSTM181 KEKIKNNDYQ 191 SIEELKDNFK201 LMCTNAMIYN211 KPETIYYKAA221 KKLLHSGMKI231 LSQERIQS |
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J Med Chem. 2020 Mar 26;63(6):3227-3237. | ||||
| REF 2 | Crystal structure of the BRD7 bromodomain in complex with BI-9564 | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.