Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T24836 Target Info
Target Name Vitamin K-dependent protein C (PROC)
Synonyms Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; PROC; Blood coagulation factor XIV; Autoprothrombin IIA; Anticoagulant protein C; Activation peptide
Target Type Successful Target
Gene Name PROC
Biochemical Class Peptidase
UniProt ID
PROC_HUMAN
Ligand General Information  Top
Ligand Name phosphatidylethanolamine Ligand Info
Canonical SMILES CC(=O)OCC(COP(=O)(O)OCCN)OC(=O)C
InChI 1S/C9H18NO8P/c1-7(11)15-5-9(18-8(2)12)6-17-19(13,14)16-4-3-10/h9H,3-6,10H2,1-2H3,(H,13,14)/t9-/m1/s1
InChIKey CFWRDBDJAOHXSH-SECBINFHSA-N
PubChem Compound ID 5327011
Drug Binding Sites of Target  Top
PDB ID: 1LQV      Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C.
Method X-ray diffraction Resolution 1.60 Å Mutation Yes [1]
PDB Sequence
ANSFLLRHSS
12
LRCIICDFAK
28
IFQN
Residue
Distance (Å)
PHE4
4.282
Residue
Distance (Å)
PDB ID: 3JTC      Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of Vitamin K-Dependent clotting and anticlotting Proteins
Method X-ray diffraction Resolution 1.60 Å Mutation No [2]
PDB Sequence
ANSFLLRHSS
12
LRCIICDFAK
28
IFQN
Residue
Distance (Å)
PHE4
4.227
Residue
Distance (Å)
References  Top
REF 1 The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem. 2002 Jul 12;277(28):24851-4.
REF 2 Structural and functional studies of Gamma-carboxyglutamic acid domains of factor VIIa and activated Protein C: role of magnesium at physiological calcium. J Mol Biol. 2013 Jun 12;425(11):1961-1981.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.