Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T34429 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-7 (CHRNA7) | ||||
| Synonyms | Nicotinic acetylcholine receptor subunit alpha 7; Nicotinic acetylcholine receptor alpha7; CHRNA7; Alpha7 nicotinic receptor; Alpha7 nAChR; Alpha-7 nAChR; Alpha(7) nicotinic receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | CHRNA7 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | EVP-6124 | Ligand Info | |||
| Canonical SMILES | C1CN2CCC1C(C2)NC(=O)C3=CC4=C(S3)C(=CC=C4)Cl | ||||
| InChI | 1S/C16H17ClN2OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9H2,(H,18,20)/t13-/m0/s1 | ||||
| InChIKey | SSRDSYXGYPJKRR-ZDUSSCGKSA-N | ||||
| PubChem Compound ID | 46196517 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7EKP human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 | ||||||
| Method | Electron microscopy | Resolution | 2.85 Å | Mutation | No | [1] |
| PDB Sequence |
GEFQRKLYKE
32 LVKNYNPLER42 PVANDSQPLT52 VYFSLSLLQI62 MDVDEKNQVL72 TTNIWLQMSW 82 TDHYLQWNVS92 EYPGVKTVRF102 PDGQIWKPDI112 LLYNSADERF122 DATFHTNVLV 132 NSSGHCQYLP142 PGIFKSSCYI152 DVRWFPFDVQ162 HCKLKFGSWS172 YGGWSLDLQM 182 QEADISGYIP192 NGEWDLVGIP202 GKRSERFYEC212 CKEPYPDVTF222 TVTMRRRTLY 232 YGLNLLIPCV242 LISALALLVF252 LLPADSGEKI262 SLGITVLLSL272 TVFMLLVAEI 282 MPATSDSVPL292 IAQYFASTMI302 IVGLSVVVTV312 IVLQYHHHDP322 DGGKMPKWTR 332 VILLNWCAWF342 LRMKRDLAKI436 LEEVRYIANR446 FRCQDESEAV456 CSEWKFAACV 466 VDRLCLMAFS476 VFTIICTIGI486 LMSAPNFVEA496 VSKDFA
|
|||||
|
|
||||||
| PDB ID: 7EKT human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596 | ||||||
| Method | Electron microscopy | Resolution | 3.02 Å | Mutation | No | [1] |
| PDB Sequence |
GEFQRKLYKE
32 LVKNYNPLER42 PVANDSQPLT52 VYFSLSLLQI62 MDVDEKNQVL72 TTNIWLQMSW 82 TDHYLQWNVS92 EYPGVKTVRF102 PDGQIWKPDI112 LLYNSADERF122 DATFHTNVLV 132 NSSGHCQYLP142 PGIFKSSCYI152 DVRWFPFDVQ162 HCKLKFGSWS172 YGGWSLDLQM 182 QEADISGYIP192 NGEWDLVGIP202 GKRSERFYEC212 CKEPYPDVTF222 TVTMRRRTLY 232 YGLNLLIPCV242 LISALALLVF252 LLPADSGEKI262 SLGITVLLSL272 TVFMLLVAEI 282 MPATSDSVPL292 IAQYFASTMI302 IVGLSVVVTV312 IVLQYHHHDP322 DGGKMPKWTR 332 VILLNWCAWF342 LRMKRDLAKI436 LEEVRYIANR446 FRCQDESEAV456 CSEWKFAACV 466 VDRLCLMAFS476 VFTIICTIGI486 LMSAPNFVEA496 VSKDFA
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of human Alpha7 nicotinic acetylcholine receptor activation. Cell Res. 2021 Jun;31(6):713-716. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.