Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T44919 Target Info
Target Name Glucagon (GCG)
Synonyms GRPP; GLP2; GLP1; GLP-1
Target Type Clinical trial Target
Gene Name GCG
Biochemical Class Glucagon
UniProt ID
GLUC_HUMAN
Ligand General Information  Top
Ligand Name L-glutamic acid Ligand Info
Canonical SMILES C(CC(=O)O)C(C(=O)O)N
InChI 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKey WHUUTDBJXJRKMK-VKHMYHEASA-N
PubChem Compound ID 33032
Drug Binding Sites of Target  Top
PDB ID: 2M5P      Solution structure of lipidated glucagon analog in water
Method Solution NMR Resolution N.A. Mutation Yes [1]
PDB Sequence
HQGTFTSDYS
11
KKLDRRAQDF
22
VQWLMNT
Residue
Distance (Å)
GLN3
3.808
GLY4
3.792
THR5
2.984
SER8
2.347
LYS12
1.686
Residue
Distance (Å)
LYS13
1.325
LEU14
4.063
ASP15
4.413
ARG17
1.851
ARG18
2.976
PDB ID: 2M5Q      Solution structure of lipidated glucagon analog in d-TFE
Method Solution NMR Resolution N.A. Mutation Yes [2]
PDB Sequence
HQGTFTSDYS
11
KKLDRRAQDF
22
VQWLMNT
Residue
Distance (Å)
THR5
4.562
PHE6
4.209
ASP9
2.520
Residue
Distance (Å)
TYR10
2.626
LYS13
1.329
References  Top
REF 1 Structural Changes Associated with Peptide Lipidation Broaden Biological Function
REF 2 Structural Changes Associated with Peptide Lipidation Broaden Biological Function

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.