Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T47623 | Target Info | |||
| Target Name | Heparanase (HPSE) | ||||
| Synonyms | Hpa1; Heparanase-1; Heparanase 8 kDa subunit; Heparanase 50 kDa subunit; HSE1; HPSE1; HPR1; HPA; HEP protein; Endo-glucoronidase | ||||
| Target Type | Successful Target | ||||
| Gene Name | HPSE | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 4-Nitrophenol | Ligand Info | |||
| Canonical SMILES | C1=CC(=CC=C1[N+](=O)[O-])O | ||||
| InChI | 1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H | ||||
| InChIKey | BTJIUGUIPKRLHP-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 980 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5E97 Glycoside Hydrolase ligand structure 1 | ||||||
| Method | X-ray diffraction | Resolution | 1.63 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
KFKNSTYSRS 168 SVDVLYTFAN178 CSGLDLIFGL188 NALLRTADLQ198 WNSSNAQLLL208 DYCSSKGYNI 218 SWELGNEPNS228 FLKKADIFIN238 GSQLGEDFIQ248 LHKLLRKSTF258 KNAKLYGPDV 268 GQPRRKTAKM278 LKSFLKAGGE288 VIDSVTWHHY298 YLNGRTATRE308 DFLNPDVLDI 318 FISSVQKVFQ328 VVESTRPGKK338 VWLGETSSAY348 GGGAPLLSDT358 FAAGFMWLDK 368 LGLSARMGIE378 VVMRQVFFGA388 GNYHLVDENF398 DPLPDYWLSL408 LFKKLVGTKV 418 LMASVQGSKR428 RKLRVYLHCT438 NTDNPRYKEG448 DLTLYAINLH458 NVTKYLRLPY 468 PFSNKQVDKY478 LLRPLGPHGL488 LSKSVQLNGL498 TLKMVDDQTL508 PPLMEKPLRP 518 GSSLGLPAFS528 YSFFVIRNAK538 VAACI> Chain B QDVVDLDFFT 45 QEPLHLVSPS55 FLSVTIDANL65 ATDPRFLILL75 GSPKLRTLAR85 GLSPAYLRFG 95 GTKTDFLIFD105 PKKE
|
|||||
|
|
||||||
| PDB ID: 5E98 Crystal structure of human heparanase in complex with HepMer M04S02a | ||||||
| Method | X-ray diffraction | Resolution | 1.63 Å | Mutation | No | [1] |
| PDB Sequence |
> Chain A
KFKNSTYSRS 168 SVDVLYTFAN178 CSGLDLIFGL188 NALLRTADLQ198 WNSSNAQLLL208 DYCSSKGYNI 218 SWELGNEPNS228 FLKKADIFIN238 GSQLGEDFIQ248 LHKLLRKSTF258 KNAKLYGPDV 268 GQPRRKTAKM278 LKSFLKAGGE288 VIDSVTWHHY298 YLNGRTATRE308 DFLNPDVLDI 318 FISSVQKVFQ328 VVESTRPGKK338 VWLGETSSAY348 GGGAPLLSDT358 FAAGFMWLDK 368 LGLSARMGIE378 VVMRQVFFGA388 GNYHLVDENF398 DPLPDYWLSL408 LFKKLVGTKV 418 LMASVQGSKR428 RKLRVYLHCT438 NTDNPRYKEG448 DLTLYAINLH458 NVTKYLRLPY 468 PFSNKQVDKY478 LLRPLGPHGL488 LSKSVQLNGL498 TLKMVDDQTL508 PPLMEKPLRP 518 GSSLGLPAFS528 YSFFVIRNAK538 VAACI> Chain B QDVVDLDFFT 45 QEPLHLVSPS55 FLSVTIDANL65 ATDPRFLILL75 GSPKLRTLAR85 GLSPAYLRFG 95 GTKTDFLIFD105 PKKE
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural characterization of human heparanase reveals insights into substrate recognition. Nat Struct Mol Biol. 2015 Dec;22(12):1016-22. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.