Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T49080 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv3.1 (KCNC1) | ||||
| Synonyms | Voltage-gated potassium channel subunit Kv4; Voltage-gated potassium channel subunit Kv3.1; Potassium voltage-gated channel subfamily C member 1; NGK2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KCNC1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Colfosceril palmitate | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC | ||||
| InChI | 1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1 | ||||
| InChIKey | KILNVBDSWZSGLL-KXQOOQHDSA-N | ||||
| PubChem Compound ID | 452110 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7PHI Human voltage-gated potassium channel Kv3.1 (with Zn) | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
SERIVINVGG
16 TRHQTHRSTL26 RTLPGTRLAW36 LAEPDAHSHF46 DYDPRADEFF56 FDRHPGVFAH 66 ILNYYRTGKL76 HCPADVCGPL86 YEEELAFWGI96 DETDVEPCCW106 MTYRQHRDAE 116 EALDRRWQPR175 IWALFEDPYS185 SRYARYVAFA195 SLFFILVSIT205 TFCLETHERF 215 NPIVNKTYYR237 EAETEAFLTY247 IEGVCVVWFT257 FEFLMRVIFC267 PNKVEFIKNS 277 LNIIDFVAIL287 PFYLEVGLSK301 AAKDVLGFLR311 VVRFVRILRI321 FKLTRHFVGL 331 RVLGHTLRAS341 TNEFLLLIIF351 LALGVLIFAT361 MIYYAERIGA371 QPNDPSASEH 381 THFKNIPIGF391 WWAVVTMTTL401 GYGDMYPQTW411 SGMLVGALCA421 LAGVLTIAMP 431 VPVIVNNFGM441 YYSLAMAKQK451 LPKKKKKHIP461 RPP
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| PDB ID: 7PHK Human voltage-gated potassium channel Kv3.1 in dimeric state (with Zn) | ||||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | No | [1] |
| PDB Sequence |
SERIVINVGG
16 TRHQTHRSTL26 RTLPGTRLAW36 LAEPDAHSHF46 DYDPRADEFF56 FDRHPGVFAH 66 ILNYYRTGKL76 HCPADVCGPL86 YEEELAFWGI96 DETDVEPCCW106 MTYRQHRDAE 116 EALDRRWQPR175 IWALFEDPYS185 SRYARYVAFA195 SLFFILVSIT205 TFCLETHERF 215 NPIVNKTYYR237 EAETEAFLTY247 IEGVCVVWFT257 FEFLMRVIFC267 PNKVEFIKNS 277 LNIIDFVAIL287 PFYLEVGLSK301 AAKDVLGFLR311 VVRFVRILRI321 FKLTRHFVGL 331 RVLGHTLRAS341 TNEFLLLIIF351 LALGVLIFAT361 MIYYAERIGA371 QPNDPSASEH 381 THFKNIPIGF391 WWAVVTMTTL401 GYGDMYPQTW411 SGMLVGALCA421 LAGVLTIAMP 431 VPVIVNNFGM441 YYSLAMAKQK451 LPKKKKKHIP461 RP
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| PDB ID: 7PHH Human voltage-gated potassium channel Kv3.1 (apo condition) | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
SERIVINVGG
16 TRHQTHRSTL26 RTLPGTRLAW36 LAEPDAHSHF46 DYDPRADEFF56 FDRHPGVFAH 66 ILNYYRTGKL76 HCPADVCGPL86 YEEELAFWGI96 DETDVEPCCW106 MTYRQHRDAE 116 EALDWRRWQP174 RIWALFEDPY184 SSRYARYVAF194 ASLFFILVSI204 TTFCLETHER 214 FNPIVNKTEY235 YREAETEAFL245 TYIEGVCVVW255 FTFEFLMRVI265 FCPNKVEFIK 275 NSLNIIDFVA285 ILPFYLEVGL295 SSKAAKDVLG308 FLRVVRFVRI318 LRIFKLTRHF 328 VGLRVLGHTL338 RASTNEFLLL348 IIFLALGVLI358 FATMIYYAER368 IGAQPNDPSA 378 SEHTHFKNIP388 IGFWWAVVTM398 TTLGYGDMYP408 QTWSGMLVGA418 LCALAGVLTI 428 AMPVPVIVNN438 FGMYYSLAMA448 KQKLPKKKKK458 HIPRPP
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| PDB ID: 7PHL Human voltage-gated potassium channel Kv3.1 (with EDTA) | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
SERIVINVGG
16 TRHQTHRSTL26 RTLPGTRLAW36 LAEPDAHSHF46 DYDPRADEFF56 FDRHPGVFAH 66 ILNYYRTGKL76 HCPADVCGPL86 YEEELAFWGI96 DETDVEPCCW106 MTYRQHRDAE 116 EALDRRWQPR175 IWALFEDPYS185 SRYARYVAFA195 SLFFILVSIT205 TFCLETHERF 215 NPIVNKTYRE238 AETEAFLTYI248 EGVCVVWFTF258 EFLMRVIFCP268 NKVEFIKNSL 278 NIIDFVAILP288 FYLEVGLSKA302 AKDVLGFLRV312 VRFVRILRIF322 KLTRHFVGLR 332 VLGHTLRAST342 NEFLLLIIFL352 ALGVLIFATM362 IYYAERIGAQ372 PNDPSASEHT 382 HFKNIPIGFW392 WAVVTMTTLG402 YGDMYPQTWS412 GMLVGALCAL422 AGVLTIAMPV 432 PVIVNNFGMY442 YSLAMAKQKL452 PKKKKKHIPR462 P
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Click to Show 3D Structure of This Binding Site
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nat Commun. 2022 Jul 15;13(1):4087. | ||||
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