Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56051 | Target Info | |||
| Target Name | Ubiquitin thioesterase L1 (UCHL1) | ||||
| Synonyms | Ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxy-terminal hydrolase L1; UCH-L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5 | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | UCHL1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Methyl 4-aminobutanoate | Ligand Info | |||
| Canonical SMILES | COC(=O)CCCN | ||||
| InChI | 1S/C5H11NO2/c1-8-5(7)3-2-4-6/h2-4,6H2,1H3 | ||||
| InChIKey | KVQGGLZHHFGHPU-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 18614 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3IFW Crystal structure of the S18Y variant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester. | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
MQLKPMEINP
10 EMLNKVLYRL20 GVAGQWRFVD30 VLGLEEESLG40 SVPAPACALL50 LLFPLTAQHE 60 NFRKKQIEEL70 KGQEVSPKVY80 FMKQTIGNSC90 GTIGLIHAVA100 NNQDKLGFED 110 GSVLKQFLSE120 TEKMSPEDRA130 KCFEKNEAIQ140 AAHDAVAQEG150 QCRVDDKVNF 160 HFILFNNVDG170 HLYELDGRMP180 FPVNHGASSE190 DTLLKDAAKV200 CREFTEREQG 210 EVRFSAVALC220 KAA
|
|||||
|
|
||||||
| PDB ID: 3KVF Crystal structure of the I93M mutant of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester | ||||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
MQLKPMEINP
10 EMLNKVLSRL20 GVAGQWRFVD30 VLGLEEESLG40 SVPAPACALL50 LLFPLTAQHE 60 NFRKKQIEEL70 KGQEVSPKVY80 FMKQTIGNSC90 GTMGLIHAVA100 NNQDKLGFED 110 GSVLKQFLSE120 TEKMSPEDRA130 KCFEKNEAIQ140 AAHDAVAQEG150 QCRVDDKVNF 160 HFILFNNVDG170 HLYELDGRMP180 FPVNHGASSE190 DTLLKDAAKV200 CREFTEREQG 210 EVRFSAVALC220 KAA
|
|||||
|
|
||||||
| PDB ID: 3KW5 Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester | ||||||
| Method | X-ray diffraction | Resolution | 2.83 Å | Mutation | No | [1] |
| PDB Sequence |
MQLKPMEINP
10 EMLNKVLSRL20 GVAGQWRFVD30 VLGLEEESLG40 SVPAPACALL50 LLFPLTAQHE 60 NFRKKQIEEL70 KGQEVSPKVY80 FMKQTIGNSC90 GTIGLIHAVA100 NNQDKLGFED 110 GSVLKQFLSE120 TEKMSPEDRA130 KCFEKNEAIQ140 AAHDAVAQEG150 QCRVDDKVNF 160 HFILFNNVDG170 HLYELDGRMP180 FPVNHGASSE190 DTLLKDAAKV200 CREFTEREQG 210 EVRFSAVALC220 KAA
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9117-22. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.