Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56871 | Target Info | |||
| Target Name | Lysine-specific demethylase 5B (KDM5B) | ||||
| Synonyms | Retinoblastomabinding protein 2 homolog 1; Retinoblastoma-binding protein 2 homolog 1; RBP2H1; RBP2-H1; RBBP2H1; PLU1; PLU-1; Lysinespecific demethylase 5B; Jumonji/ARID domaincontaining protein 1B; Jumonji/ARID domain-containing protein 1B; JARID1B; Histone demethylase JARID1B; Cancer/testis antigen 31; CT31 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KDM5B | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Fumaric acid | Ligand Info | |||
| Canonical SMILES | C(=CC(=O)O)C(=O)O | ||||
| InChI | 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+ | ||||
| InChIKey | VZCYOOQTPOCHFL-OWOJBTEDSA-N | ||||
| PubChem Compound ID | 444972 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5FY4 Crystal structure of the catalytic domain of human JARID1B in complex with succinate | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | No | [1] |
| PDB Sequence |
SMFLPPPECP
33 VFEPSWEEFA43 DPFAFIHKIR53 PIAEQTGICK63 VRPPPDWQPP73 FACDVDKLHF 83 TPRIQRLNEL93 EAQTRVKRDY377 TLRTFGEMAD387 AFKSDYFNMP397 VHMVPTELVE 407 KEFWRLVSTI417 EEDVTVEYGA427 DIASKEFGSG437 FPVRDIKLSP449 EEEEYLDSGW 459 NLNNMPVMEQ469 SVLAHITADI479 CGMKLPWLYV489 GMCFSSFCWH499 IEDHWSYSIN 509 YLHWGEPKTW519 YGVPGYAAEQ529 LENVMKKLAP539 ELFVSQPDLL549 HQLVTIMNPN 559 TLMTHEVPVY569 RTNQCAGEFV579 ITFPRAYHSG589 FNQGFNFAEA599 VNFCTVDWLP 609 LGRQCVEHYR619 LLHRYCVFSH629 DEMICKMASK639 ADVLDVVVAS649 TVQKDMAIMI 659 EDEKALRETV669 RKLGVIDSER679 MDFELLPDDE689 RQCVKCKTTC699 FMSAISCSCK 709 PGLLVCLHHV719 KELCSCPPYK729 YKLRYRYTLD739 DLYPMMNALK749 LRAE |
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| PDB ID: 5FY5 Crystal structure of the catalytic domain of human JARID1B in complex with fumarate | ||||||
| Method | X-ray diffraction | Resolution | 2.47 Å | Mutation | No | [2] |
| PDB Sequence |
SMFLPPPECP
33 VFEPSWEEFA43 DPFAFIHKIR53 PIAEQTGICK63 VRPPPDWQPP73 FACDVDKLHF 83 TPRIQRLNEL93 EAQTRVRDYT378 LRTFGEMADA388 FKSDYFNMPV398 HMVPTELVEK 408 EFWRLVSTIE418 EDVTVEYGAD428 IASKEFGSGF438 PVRDIKLSPE450 EEEYLDSGWN 460 LNNMPVMEQS470 VLAHITADIC480 GMKLPWLYVG490 MCFSSFCWHI500 EDHWSYSINY 510 LHWGEPKTWY520 GVPGYAAEQL530 ENVMKKLAPE540 LFVSQPDLLH550 QLVTIMNPNT 560 LMTHEVPVYR570 TNQCAGEFVI580 TFPRAYHSGF590 NQGFNFAEAV600 NFCTVDWLPL 610 GRQCVEHYRL620 LHRYCVFSHD630 EMICKMASKA640 DVLDVVVAST650 VQKDMAIMIE 660 DEKALRETVR670 KLGVIDSERM680 DFELLPDDER690 QCVKCKTTCF700 MSAISCSCKP 710 GLLVCLHHVK720 ELCSCPPYKY730 KLRYRYTLDD740 LYPMMNALKL750 RAE |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Succinate | ||||
| REF 2 | Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Fumarate | ||||
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