Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T57278 Target Info
Target Name Ephrin type-A receptor 2 (EPHA2)
Synonyms Tyrosine-protein kinase receptor ECK; Epithelial cell kinase; EphA2receptor; ECK
Target Type Clinical trial Target
Gene Name EPHA2
Biochemical Class Kinase
UniProt ID
EPHA2_HUMAN
Ligand General Information  Top
Ligand Name Biotin Ligand Info
Canonical SMILES C1C2C(C(S1)CCCCC(=O)O)NC(=O)N2
InChI 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChIKey YBJHBAHKTGYVGT-ZKWXMUAHSA-N
PubChem Compound ID 171548
Drug Binding Sites of Target  Top
PDB ID: 6NJZ      EphA2 LBD in complex with YSA-GSGSK-bio peptide
Method X-ray diffraction Resolution 1.90 Å Mutation No [1]
PDB Sequence
GEVVLLDFAA
36
AGGELGWLTH
46
PYGKGWDLMQ
56
NIMNDMPIYM
66
YSVCNVMSGD
76

QDNWLRTNWV
86
YRGEAERIFI
96
ELKFTVRDCN
106
SFPGGASSCK
116
ETFNLYYAES
126

DLDYGTNFQK
136
RLFTKIDTIA
146
PDEITVSSDF
156
EARHVKLNVE
166
ERSVGPLTRK
176

GFYLAFQDIG
186
ACVALLSVRV
196
YYKKAHHHH
Residue
Distance (Å)
LEU44
2.854
THR45
4.897
Residue
Distance (Å)
TYR48
3.896
THR132
2.830
PDB ID: 6NKP      EphA2 LBD in complex with bA-WLA-YSKbio peptide
Method X-ray diffraction Resolution 2.03 Å Mutation No [1]
PDB Sequence
PGEVVLLDFA
35
AAGGELGWLT
45
HPYGKGWDLM
55
QNIMNDMPIY
65
MYSVCNVMSG
75

DQDNWLRTNW
85
VYRGEAERIF
95
IELKFTVRDC
105
NSFPGGASSC
115
KETFNLYYAE
125

SDLDYGTNFQ
135
KRLFTKIDTI
145
APDEITVSSD
155
FEARHVKLNV
165
EERSVGPLTR
175

KGFYLAFQDI
185
GACVALLSVR
195
VYYKK
Residue
Distance (Å)
LEU44
3.718
THR45
4.573
Residue
Distance (Å)
TYR48
3.078
THR132
2.895
References  Top
REF 1 Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling. J Biol Chem. 2019 May 31;294(22):8791-8805.

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