Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58449 | Target Info | |||
| Target Name | Cyclin-dependent kinase 7 (CDK7) | ||||
| Synonyms | TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDK7 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | L-serine-O-phosphate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)N)OP(=O)(O)O | ||||
| InChI | 1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 | ||||
| InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N | ||||
| PubChem Compound ID | 68841 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6XD3 Structure of the human CAK in complex with THZ1 | ||||||
| Method | Electron microscopy | Resolution | 3.30 Å | Mutation | No | [1] |
| PDB Sequence |
KRYEKLDFLG
19 EGQFATVYKA29 RDKNTNQIVA39 IKKIKLAKDG54 INRTALREIK64 LLQELSHPNI 74 IGLLDAFGHK84 SNISLVFDFM94 ETDLEVIIKD104 NSLVLTPSHI114 KAYMLMTLQG 124 LEYLHQHWIL134 HRDLKPNNLL144 LDENGVLKLA154 DFGLAKSFGP165 NRAYTHQVVT 175 RWYRAPELLF185 GARMYGVGVD195 MWAVGCILAE205 LLLRVPFLPG215 DSDLDQLTRI 225 FETLGTPTEE235 QWPDMCSLPD245 YVTFKSFPGI255 PLHHIFSAAG265 DDLLDLIQGL 275 FLFNPCARIT285 ATQALKMKYF295 SNRPGPTPGC305 QLPRPNC
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| PDB ID: 6XBZ Structure of the human CDK-activating kinase | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | No | [1] |
| PDB Sequence |
KRYEKLDFLG
19 EGQFATVYKA29 RDKNTNQIVA39 IKKIKLAKDG54 INRTALREIK64 LLQELSHPNI 74 IGLLDAFGHK84 SNISLVFDFM94 ETDLEVIIKD104 NSLVLTPSHI114 KAYMLMTLQG 124 LEYLHQHWIL134 HRDLKPNNLL144 LDENGVLKLA154 DFGLAKSFGP165 NRAYTHQVVT 175 RWYRAPELLF185 GARMYGVGVD195 MWAVGCILAE205 LLLRVPFLPG215 DSDLDQLTRI 225 FETLGTPTEE235 QWPDMCSLPD245 YVTFKSFPGI255 PLHHIFSAAG265 DDLLDLIQGL 275 FLFNPCARIT285 ATQALKMKYF295 SNRPGPTPGC305 QLPRPNC
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The cryoelectron microscopy structure of the human CDK-activating kinase. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22849-22857. | ||||
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