Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T63068 | Target Info | |||
| Target Name | Serum albumin (ALB) | ||||
| Synonyms | Serum albumin | ||||
| Target Type | Successful Target | ||||
| Gene Name | ALB | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Myristic acid | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCCCC(=O)O | ||||
| InChI | 1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16) | ||||
| InChIKey | TUNFSRHWOTWDNC-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 11005 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6HSC Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
|
ARG10
4.143
LEU14
3.690
PHE19
4.793
LEU22
3.831
VAL23
3.603
ALA26
4.692
LEU66
4.104
PHE70
4.546
ARG117
2.627
MET123
4.040
PHE134
3.789
LEU135
3.977
TYR138
3.311
LEU139
4.692
ILE142
3.688
TYR150
2.416
PRO152
3.498
LEU154
3.780
PHE157
3.893
ALA158
3.403
TYR161
3.195
PHE165
3.285
LEU182
4.001
ARG186
3.117
LYS199
3.862
ARG209
3.282
LYS212
3.970
ALA213
3.757
TRP214
4.237
VAL216
4.006
ARG218
3.835
LEU219
3.723
ARG222
3.703
PHE223
4.341
PHE228
3.505
SER232
3.001
LEU238
3.622
VAL241
4.152
HIS242
3.354
LEU250
3.625
LEU251
3.615
ALA254
3.565
ARG257
3.002
ALA258
3.265
LEU260
3.986
ILE264
4.138
LEU283
3.421
LEU284
3.576
SER287
2.709
ILE290
3.405
ALA291
3.609
ASP324
3.200
VAL325
3.524
LEU327
3.521
GLY328
4.003
MET329
3.991
SER342
2.400
VAL344
3.416
LEU345
3.824
ARG348
2.849
ALA350
4.294
GLU354
4.865
PRO384
3.583
LEU387
3.642
ILE388
3.705
ASN391
3.915
TYR401
2.293
PHE403
3.967
ASN405
3.710
LEU407
3.800
ARG410
3.763
TYR411
2.366
LYS414
4.587
VAL415
1.492
VAL418
4.024
LEU423
4.528
VAL426
4.496
LEU430
3.816
GLY431
4.758
VAL433
4.309
GLY434
3.795
MET446
3.618
ALA449
3.868
GLU450
3.526
LEU453
3.617
LEU457
3.702
LEU460
3.803
VAL473
4.516
ARG485
3.015
PRO486
4.598
PHE488
3.598
SER489
2.745
LEU491
4.763
PHE502
4.216
PHE507
3.519
PHE509
4.540
LYS525
3.080
GLN526
4.874
ALA528
3.740
LEU529
3.751
LEU532
3.585
HIS535
4.876
VAL547
3.978
MET548
3.866
PHE551
3.479
LEU575
4.644
VAL576
3.911
SER579
4.028
GLN580
4.863
|
|||||
| PDB ID: 7OV1 Structure of Human Serum Albumin in complex with Myristic Acid | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [2] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
|
ARG10
3.951
LEU14
3.650
PHE19
4.356
LEU22
4.216
VAL23
3.911
ALA26
4.453
LEU66
4.851
LEU115
4.011
VAL116
4.725
ARG117
2.384
PRO118
4.723
MET123
4.533
PHE134
4.311
LEU135
4.213
TYR138
3.493
LEU139
4.047
ILE142
3.679
ARG145
3.898
HIS146
2.884
PHE149
3.685
TYR150
2.439
PRO152
3.703
LEU154
3.692
PHE157
3.750
ALA158
3.570
TYR161
3.171
PHE165
3.858
LEU182
3.942
LEU185
3.636
ARG186
3.790
GLY189
3.465
LYS190
3.839
SER193
3.654
LYS199
3.731
ARG209
4.096
ALA210
3.620
LYS212
3.889
ALA213
3.741
TRP214
3.407
VAL216
3.741
ARG218
4.301
LEU219
3.934
ARG222
3.403
PHE223
4.520
PHE228
4.405
SER232
4.771
LEU238
4.153
VAL241
3.589
HIS242
3.237
LEU250
4.294
LEU251
3.991
ALA254
3.678
ARG257
3.154
ALA258
3.708
LEU260
4.058
ILE264
3.620
LEU283
3.568
LEU284
3.556
SER287
2.523
HIS288
4.979
ILE290
4.027
ALA291
4.027
ASP324
3.571
LEU327
3.688
GLY328
4.195
LEU331
4.299
SER342
2.803
VAL344
3.519
LEU345
4.183
LEU347
4.408
ARG348
2.887
ALA350
3.912
LYS351
3.470
GLU354
3.855
PRO384
3.689
LEU387
3.692
ILE388
3.822
ASN391
3.244
CYS392
4.850
TYR401
2.715
PHE403
4.387
ASN405
3.894
LEU407
3.866
ARG410
3.552
TYR411
2.317
VAL415
4.361
VAL418
3.992
THR422
4.810
LEU423
3.621
VAL426
4.316
LEU430
3.412
VAL433
3.619
GLY434
4.214
CYS438
4.794
MET446
3.690
ALA449
4.016
GLU450
3.890
LEU453
4.050
LEU457
3.963
LEU460
3.410
SER480
3.819
VAL482
3.729
ARG485
2.785
PRO486
4.300
PHE488
3.881
SER489
3.806
LEU491
4.127
PHE502
4.013
PHE507
3.491
PHE509
4.266
LYS525
3.678
ALA528
4.384
LEU529
3.942
LEU532
4.050
HIS535
3.605
VAL547
3.698
MET548
3.573
PHE551
3.714
ALA552
4.679
LEU575
3.806
VAL576
4.419
SER579
3.502
GLN580
3.580
LEU583
4.842
|
|||||
| PDB ID: 7OV5 Structure of Human Serum Albumin in complex with Aristolochic Acid II at 1.9 A resolution | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [3] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
|
ARG10
4.064
LEU14
4.215
LEU22
4.226
VAL23
4.341
ALA26
4.132
LEU66
4.349
PHE70
3.735
LEU115
4.383
VAL116
4.915
ARG117
2.316
PRO118
4.202
MET123
3.765
PHE134
4.082
LEU135
4.223
TYR138
3.460
LEU139
4.093
ILE142
4.122
TYR150
2.654
PRO152
3.574
LEU154
3.614
PHE157
4.041
ALA158
3.637
TYR161
3.364
PHE165
3.505
LEU182
4.290
ARG186
3.614
PHE206
4.863
ARG209
3.479
ALA210
3.959
LYS212
3.885
ALA213
4.065
VAL216
3.660
VAL235
4.533
LEU250
3.903
LEU251
3.610
ALA254
3.568
ARG257
3.430
ALA258
3.487
ALA261
4.846
LEU283
3.439
LEU284
3.615
SER287
2.579
ASP324
3.838
LEU327
3.688
GLY328
3.919
LEU331
4.980
SER342
2.824
VAL344
3.439
LEU345
4.213
LEU347
4.409
ARG348
2.745
ALA350
3.656
LYS351
4.022
GLU354
4.355
PRO384
3.626
LEU387
3.528
ILE388
3.532
ASN391
3.333
CYS392
4.998
TYR401
2.620
PHE403
3.567
ASN405
3.365
LEU407
4.203
ARG410
2.553
TYR411
2.337
VAL415
4.464
VAL418
4.214
THR422
4.571
LEU423
4.044
VAL426
3.698
LEU430
3.708
VAL433
3.843
GLY434
4.382
CYS438
4.991
MET446
3.972
ALA449
4.112
GLU450
3.828
LEU453
3.473
LEU457
4.078
LEU460
3.659
SER480
3.884
VAL482
3.710
ARG485
2.735
PRO486
4.367
PHE488
3.569
SER489
3.303
LEU491
4.859
PHE502
4.026
PHE507
3.757
PHE509
4.253
LYS525
3.447
ALA528
4.135
LEU529
4.045
LEU532
3.818
HIS535
4.686
VAL547
3.668
MET548
3.809
PHE551
3.804
LEU575
4.297
VAL576
3.908
SER579
3.336
GLN580
4.229
|
|||||
| PDB ID: 7OV6 Structure of Human Serum Albumin in complex with Aristolochic Acid I at 1.9 A resolution - Optimized | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [4] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:46 or .A:66 or .A:70 or .A:150 or .A:152 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:219 or .A:222 or .A:223 or .A:228 or .A:232 or .A:235 or .A:238 or .A:241 or .A:242 or .A:245 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:287 or .A:290 or .A:291 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.903
LEU14
4.137
PHE19
4.940
LEU22
4.187
VAL23
3.751
ALA26
4.376
VAL46
4.364
LEU66
3.273
PHE70
3.973
TYR150
2.564
PRO152
3.756
LYS199
3.102
ARG209
3.148
ALA210
3.491
LYS212
3.802
ALA213
3.787
TRP214
2.778
VAL216
3.689
LEU219
3.685
ARG222
3.908
PHE223
4.511
PHE228
4.751
SER232
4.386
VAL235
4.830
LEU238
3.962
VAL241
3.248
HIS242
3.106
CYS245
4.604
LEU250
3.719
LEU251
3.586
ALA254
3.756
ARG257
3.163
ALA258
3.417
LEU260
3.812
ILE264
3.801
LEU283
3.795
LEU284
3.792
SER287
2.554
ILE290
3.803
ALA291
3.663
ASP324
3.362
LEU327
3.365
GLY328
3.434
LEU331
4.621
SER342
2.628
VAL344
3.555
LEU345
3.985
LEU347
3.970
ARG348
2.963
ALA350
4.202
LYS351
4.269
GLU354
3.869
PRO384
3.654
LEU387
3.559
ILE388
3.558
ASN391
3.466
TYR401
2.592
PHE403
4.661
ASN405
3.871
LEU407
4.946
ARG410
2.572
TYR411
3.090
VAL415
4.288
VAL418
4.298
THR422
4.296
LEU423
3.463
VAL426
3.143
LEU430
3.812
VAL433
3.827
GLY434
4.250
CYS438
4.990
MET446
3.853
ALA449
4.207
GLU450
3.855
LEU453
3.489
LEU457
4.212
LEU460
3.124
VAL473
4.818
SER480
3.962
VAL482
3.514
ARG485
2.833
PRO486
4.278
PHE488
3.611
SER489
4.120
LEU491
4.375
PHE502
3.706
PHE507
3.493
PHE509
4.267
LYS525
3.186
ALA528
4.205
LEU529
4.047
LEU532
3.937
HIS535
4.449
VAL547
3.950
MET548
3.625
PHE551
3.475
ALA552
4.338
LEU575
3.666
VAL576
4.226
SER579
3.560
GLN580
4.617
|
|||||
| PDB ID: 7WOJ Crystal structure of HSA-Myr complex soaked with cisplatin for one week | ||||||
| Method | X-ray diffraction | Resolution | 2.89 Å | Mutation | No | [5] |
| PDB Sequence |
VAHRFKDLGE
16 ENFKALVLIA26 FAQYLQQCPF36 EDHVKLVNEV46 TEFAKTCVAD56 ESAENCDLHT 68 LFGDKLCTVA78 TLRETYGEMA88 DCCAKQEPER98 NECFLQHKDD108 NPNLPRLVRP 118 EVDVMCTAFH128 DNEETFLKKY138 LYEIARRHPY148 FYAPELLFFA158 KRYKAAFTEC 168 CQAADKAACL178 LPKLDELRDE188 GKASSAKQRL198 KCASLQKFGE208 RAFKAWAVAR 218 LSQRFPKAEF228 AEVSKLVTDL238 TKVHTECCHG248 DLLECADDRA258 DLAKYICENQ 268 DSISSKLKEC278 CEKPLLEKSH288 CIAEVENDEM298 PADLPSLAAD308 FVESKDVCKN 318 YAEAKDVFLG328 MFLYEYARRH338 PDYSVVLLLR348 LAKTYETTLE358 KCCAAADPHE 368 CYFDEFKPLV381 EEPQNLIKQN391 CELFEQLGEY401 KFQNALLVRY411 TKKVPQVSTP 421 TLVEVSRNLG431 KVGSKCCKHP441 EAKRMPCAED451 YLSVVLNQLC461 VLHEKTPVSD 471 RVTKCCTESL481 VNRRPCFSAL491 EVDETYVPKE501 FNAETFTFHA511 DICTLSEKER 521 QIKKQTALVE531 LVKHKPKATK541 EQLKAVMDDF551 AAFVEKCETC567 FAEEGKKLVA 577 ASQAALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:115 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:228 or .A:232 or .A:235 or .A:236 or .A:238 or .A:241 or .A:242 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:261 or .A:264 or .A:283 or .A:284 or .A:287 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:347 or .A:350 or .A:351 or .A:354 or .A:387 or .A:391 or .A:401 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:453 or .A:457 or .A:460 or .A:473 or .A:480 or .A:481 or .A:482 or .A:485 or .A:488 or .A:489 or .A:491 or .A:507 or .A:509 or .A:521 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:555 or .A:556 or .A:576 or .A:579; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU14
3.853
PHE19
3.338
LEU22
4.114
VAL23
3.342
VAL46
4.762
LEU115
4.621
ARG117
3.542
MET123
3.702
PHE134
3.689
LEU135
3.439
TYR138
3.269
LEU139
3.628
ILE142
4.215
TYR150
2.382
PRO152
3.395
LEU154
3.961
PHE157
4.177
ALA158
3.715
TYR161
3.030
PHE165
3.497
LEU182
3.692
ARG186
3.897
LYS199
3.622
ARG209
3.508
ALA210
3.734
LYS212
3.671
ALA213
3.829
TRP214
3.837
VAL216
3.778
ARG218
3.503
LEU219
3.546
ARG222
4.005
PHE223
4.268
PHE228
3.702
SER232
2.809
VAL235
4.105
THR236
4.067
LEU238
3.143
VAL241
4.619
HIS242
2.713
LEU250
4.084
LEU251
3.749
ALA254
3.340
ARG257
3.353
ALA258
3.300
LEU260
3.639
ALA261
3.911
ILE264
4.461
LEU283
3.605
LEU284
3.673
SER287
3.396
ILE290
3.567
ALA291
3.298
ASP324
3.559
VAL325
4.196
LEU327
3.517
GLY328
3.563
LEU331
3.977
LEU347
3.859
ALA350
3.665
LYS351
3.841
GLU354
3.539
LEU387
3.448
ASN391
3.717
TYR401
3.279
LEU407
4.857
ARG410
4.420
TYR411
2.318
LYS414
4.417
VAL415
3.658
VAL418
3.807
LEU423
3.823
VAL426
4.048
LEU430
3.610
LEU453
3.982
LEU457
3.733
LEU460
3.660
VAL473
4.647
SER480
4.772
LEU481
4.380
VAL482
3.689
ARG485
3.683
PHE488
3.643
SER489
2.530
LEU491
4.945
PHE507
3.728
PHE509
3.738
ARG521
4.805
LYS525
2.771
ALA528
3.872
LEU529
4.041
LEU532
3.646
VAL547
4.004
MET548
3.776
PHE551
3.696
ALA552
4.103
VAL555
4.311
GLU556
4.820
VAL576
3.900
SER579
3.771
|
|||||
| PDB ID: 6YG9 CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN (HSA) IN COMPLEX WITH GN-07. | ||||||
| Method | X-ray diffraction | Resolution | 1.89 Å | Mutation | No | [6] |
| PDB Sequence |
AHKSEVAHRF
11 KDLGEENFKA21 LVLIAFAQYL31 QQCPFEDHVK41 LVNEVTEFAK51 TCVADESAEN 61 CDKSLHTLFG71 DKLCTVATLR81 ETYGEMADCC91 AKQEPERNEC101 FLQHKDDNPN 111 LPRLVRPEVD121 VMCTAFHDNE131 ETFLKKYLYE141 IARRHPYFYA151 PELLFFAKRY 161 KAAFTECCQA171 ADKAACLLPK181 LDELRDEGKA191 SSAKQRLKCA201 SLQKFGERAF 211 KAWAVARLSQ221 RFPKAEFAEV231 SKLVTDLTKV241 HTECCHGDLL251 ECADDRADLA 261 KYICENQDSI271 SSKLKECCEK281 PLLEKSHCIA291 EVENDEMPAD301 LPSLAADFVE 311 SKDVCKNYAE321 AKDVFLGMFL331 YEYARRHPDY341 SVVLLLRLAK351 TYETTLEKCC 361 APHECYAKVF374 DEFKPLVEEP384 QNLIKQNCEL394 FEQLGEYKFQ404 NALLVRYTKK 414 VPQVSTPTLV424 EVSRNLGKVG434 SKCCKHPEAK444 RMPCAEDYLS454 VVLNQLCVLH 464 EKTPVSDRVT474 KCCTESLVNR484 RPCFSALEVD494 ETYVPKEFNA504 ETFTFHADIC 514 TLSEKERQIK524 KQTALVELVK534 HKPKATKEQL544 KAVMDDFAET566 CFAEEGKKLV 576 AASQAALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:206 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:223 or .A:238 or .A:241 or .A:242 or .A:257 or .A:260 or .A:264 or .A:287 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:411 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:545 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU115
4.454
VAL116
4.923
ARG117
2.755
PRO118
4.735
MET123
3.674
PHE134
4.498
LEU135
4.124
TYR138
3.505
LEU139
4.524
ILE142
3.446
LEU154
4.766
PHE157
4.593
ALA158
3.619
TYR161
3.546
PHE165
3.207
LEU182
3.801
ARG186
3.430
PHE206
4.883
ARG209
3.763
ALA210
3.378
LYS212
4.329
ALA213
3.485
TRP214
4.505
VAL216
3.842
ARG218
4.196
LEU219
4.087
PHE223
4.530
LEU238
3.539
VAL241
4.720
HIS242
4.304
ARG257
3.409
LEU260
3.860
ILE264
3.620
SER287
3.207
ILE290
3.551
ALA291
3.926
ASP324
3.185
VAL325
4.356
LEU327
3.605
GLY328
3.671
LEU331
4.642
SER342
2.777
VAL344
3.389
LEU345
3.863
LEU347
3.838
ARG348
2.717
ALA350
3.641
LYS351
3.885
GLU354
3.265
PRO384
3.774
LEU387
3.336
ILE388
3.779
ASN391
3.897
TYR401
3.160
PHE403
4.200
ASN405
3.417
LEU407
4.699
TYR411
3.142
VAL415
3.827
VAL418
3.619
THR422
4.826
LEU423
3.820
VAL426
3.530
LEU430
3.454
VAL433
4.299
GLY434
4.207
MET446
3.648
ALA449
3.774
GLU450
4.242
LEU453
3.630
LEU457
3.860
LEU460
3.489
VAL473
3.594
VAL482
4.960
ARG485
2.815
PRO486
4.562
PHE488
3.640
SER489
3.648
LEU491
4.876
PHE502
3.739
PHE507
3.643
PHE509
3.672
LYS525
3.292
ALA528
3.739
LEU529
3.816
LEU532
3.602
HIS535
4.096
LYS545
3.270
LEU575
3.929
VAL576
4.033
SER579
3.702
GLN580
4.657
|
|||||
| PDB ID: 1N5U X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [7] |
| PDB Sequence |
AHKSEVAHRF
11 KDLGEENFKA21 LVLIAFAQYL31 QQCPFEDHVK41 LVNEVTEFAK51 TCVADESAEN 61 CDKSLHTLFG71 DKLCTVATLR81 ETYGEMADCC91 AKQEPERNEC101 FLQHKDDNPN 111 LPRLVRPEVD121 VMCTAFHDNE131 ETFLKKYLYE141 IARRHPYFYA151 PELLFFAKRY 161 KAAFTECCQA171 ADKAACLLPK181 LDELRDEGKA191 SSAKQRLKCA201 SLQKFGERAF 211 KAWAVARLSQ221 RFPKAEFAEV231 SKLVTDLTKV241 HTECCHGDLL251 ECADDRADLA 261 KYICENQDSI271 SSKLKECCEK281 PLLEKSHCIA291 EVENDEMPAD301 LPSLAADFVE 311 SKDVCKNYAE321 AKDVFLGMFL331 YEYARRHPDY341 SVVLLLRLAK351 TYETTLEKCC 361 AAADPHECYA371 KVFDEFKPLV381 EEPQNLIKQN391 CELFEQLGEY401 KFQNALLVRY 411 TKKVPQVSTP421 TLVEVSRNLG431 KVGSKCCKHP441 EAKRMPCAED451 YLSVVLNQLC 461 VLHEKTPVSD471 RVTKCCTESL481 VNRRPCFSAL491 EVDETYVPKE501 FNAETFTFHA 511 DICTLSEKER521 QIKKQTALVE531 LVKHKPKATK541 EQLKAVMDDF551 AAFVEKCCKA 561 DDKETCFAEE571 GKKLVAASQA581 ALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:27 or .A:46 or .A:66 or .A:70 or .A:150 or .A:152 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:235 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:431 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.346
LEU14
4.032
PHE19
4.533
LEU22
3.605
VAL23
3.507
PHE27
4.839
VAL46
4.279
LEU66
3.420
PHE70
3.450
TYR150
2.575
PRO152
3.701
ARG209
3.732
ALA210
3.352
LYS212
4.275
ALA213
3.701
VAL216
3.570
PHE228
4.280
SER232
3.297
VAL235
3.564
LEU250
4.362
LEU251
3.685
ALA254
3.612
ARG257
3.300
ALA258
3.403
LEU283
3.603
LEU284
3.991
SER287
2.818
ASP324
3.346
LEU327
4.161
GLY328
3.727
LEU331
4.667
SER342
2.583
VAL344
3.374
LEU345
4.008
LEU347
4.022
ARG348
2.570
ALA350
3.921
LYS351
4.170
GLU354
3.893
PRO384
4.159
LEU387
3.334
ILE388
3.415
ASN391
2.774
TYR401
3.215
PHE403
3.693
ASN405
3.764
LEU407
3.641
ARG410
3.178
TYR411
2.643
VAL415
3.648
VAL418
3.330
THR422
3.808
LEU423
3.612
VAL426
3.491
LEU430
3.316
GLY431
4.716
VAL433
3.789
GLY434
3.782
CYS438
4.807
MET446
3.767
ALA449
4.001
GLU450
3.917
LEU453
3.796
LEU457
3.852
LEU460
3.474
SER480
3.549
VAL482
3.691
ARG485
3.027
PRO486
4.215
PHE488
3.480
SER489
3.906
PHE502
3.745
PHE507
3.360
PHE509
3.831
LYS525
3.183
ALA528
3.870
LEU529
3.998
LEU532
4.253
HIS535
4.683
VAL547
3.793
MET548
3.522
PHE551
3.537
ALA552
3.664
LEU575
3.994
VAL576
4.153
SER579
3.457
GLN580
4.280
|
|||||
| PDB ID: 4L8U X-ray study of human serum albumin complexed with 9 amino camptothecin | ||||||
| Method | X-ray diffraction | Resolution | 2.01 Å | Mutation | No | [8] |
| PDB Sequence |
AHKSEVAHRF
11 KDLGEENFKA21 LVLIAFAQYL31 QQCPFEDHVK41 LVNEVTEFAK51 TCVADESAEN 61 CDKSLHTLFG71 DKLCTVATLR81 ETYGEMADCC91 AKQEPERNEC101 FLQHKDDNPN 111 LPRLVRPEVD121 VMCTAFHDNE131 ETFLKKYLYE141 IARRHPYFYA151 PELLFFAKRY 161 KAAFTECCQA171 ADKAACLLPK181 LDELRDEGKA191 SSAKQRLKCA201 SLQKFGERAF 211 KAWAVARLSQ221 RFPKAEFAEV231 SKLVTDLTKV241 HTECCHGDLL251 ECADDRADLA 261 KYICENQDSI271 SSKLKECCEK281 PLLEKSHCIA291 EVENDEMPAD301 LPSLAADFVE 311 SKDVCKNYAE321 AKDVFLGMFL331 YEYARRHPDY341 SVVLLLRLAK351 TYETTLEKCC 361 AAADPHECYA371 KVFDEFKPLV381 EEPQNLIKQN391 CELFEQLGEY401 KFQNALLVRY 411 TKKVPQVSTP421 TLVEVSRNLG431 KVGSKCCKHP441 EAKRMPCAED451 YLSVVLNQLC 461 VLHEKTPVSD471 RVTKCCTESL481 VNRRPCFSAL491 EVDETYVPKE501 FNAETFTFHA 511 DICTLSEKER521 QIKKQTALVE531 LVKHKPKATK541 EQLKAVMDDF551 AAFVEKCCKA 561 DDKETCFAEE571 GKKLVAASQA581 ALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:70 or .A:150 or .A:152 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:261 or .A:283 or .A:284 or .A:286 or .A:287 or .A:288 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.881
ARG10
3.990
LEU14
3.990
PHE19
4.441
LEU22
4.097
VAL23
3.570
VAL46
4.583
LEU66
4.263
PHE70
4.373
TYR150
2.313
PRO152
3.858
ARG209
4.107
ALA210
3.582
LYS212
4.115
ALA213
3.602
VAL216
4.040
PHE228
4.870
SER232
3.929
LEU250
4.239
LEU251
3.970
ALA254
3.489
ARG257
3.280
ALA258
3.744
ALA261
4.830
LEU283
4.000
LEU284
3.679
LYS286
4.908
SER287
2.421
HIS288
4.915
ASP324
3.501
VAL325
4.707
LEU327
3.670
GLY328
4.042
LEU331
4.343
SER342
2.656
VAL344
3.465
LEU345
4.027
LEU347
4.013
ARG348
2.773
ALA350
3.779
LYS351
4.235
GLU354
4.087
PRO384
3.789
LEU387
3.819
ILE388
3.862
ASN391
3.095
TYR401
3.135
PHE403
4.141
ASN405
3.911
LEU407
3.973
ARG410
3.069
TYR411
2.251
VAL415
4.287
VAL418
3.442
LEU423
3.625
VAL426
4.264
LEU430
3.206
VAL433
3.818
GLY434
4.206
MET446
4.190
ALA449
3.815
GLU450
3.806
LEU453
3.610
LEU457
3.890
LEU460
3.537
SER480
3.938
VAL482
3.462
ARG485
2.944
PRO486
4.215
PHE488
3.604
SER489
3.727
LEU491
4.385
PHE502
4.005
PHE507
3.762
PHE509
4.768
LYS525
3.265
ALA528
3.657
LEU529
3.579
LEU532
3.827
HIS535
4.196
VAL547
3.776
MET548
4.010
PHE551
3.707
ALA552
4.734
LEU575
4.036
VAL576
4.040
SER579
3.648
GLN580
4.177
|
|||||
| PDB ID: 3A73 Crystal Structure Analysis of Human serum albumin complexed with delta 12-prostaglandin J2 | ||||||
| Method | X-ray diffraction | Resolution | 2.19 Å | Mutation | No | [9] |
| PDB Sequence |
AHKSEVAHRF
11 KDLGEENFKA21 LVLIAFAQYL31 QQCPFEDHVK41 LVNEVTEFAK51 TCVADESAEN 61 CDKSLHTLFG71 DKLCTVATLR81 ETYGEMADCC91 AKQEPERNEC101 FLQHKDDNPN 111 LPRLVRPEVD121 VMCTAFHDNE131 ETFLKKYLYE141 IARRHPYFYA151 PELLFFAKRY 161 KAAFTECCQA171 ADKAACLLPK181 LDELRDEGKA191 SSAKQRLKCA201 SLQKFGERAF 211 KAWAVARLSQ221 RFPKAEFAEV231 SKLVTDLTKV241 HTECCHGDLL251 ECADDRADLA 261 KYICENQDSI271 SSKLKECCEK281 PLLEKSHCIA291 EVENDEMPAD301 LPSLAADFVE 311 SKDVCKNYAE321 AKDVFLGMFL331 YEYARRHPDY341 SVVLLLRLAK351 TYETTLEKCC 361 AAADPHECYA371 KVFDEFKPLV381 EEPQNLIKQN391 CELFEQLGEY401 KFQNALLVRY 411 TKKVPQVSTP421 TLVEVSRNLG431 KVGSKCCKHP441 EAKRMPCAED451 YLSVVLNQLC 461 VLHEKTPVSD471 RVTKCCTESL481 VNRRPCFSAL491 EVDETYVPKE501 FNAETFTFHA 511 DICTLSEKER521 QIKKQTALVE531 LVKHKPKATK541 EQLKAVMDDF551 AAFVEKCCCF 568 AEEGKKLVAA578 SQAALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:26 or .A:30 or .A:70 or .A:150 or .A:152 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:235 or .A:238 or .A:241 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:287 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:437 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:480 or .A:481 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.118
LEU14
3.476
LEU22
3.716
ALA26
3.616
TYR30
4.627
PHE70
3.679
TYR150
2.564
PRO152
3.836
LYS199
4.688
ARG209
3.952
ALA210
3.745
LYS212
4.429
ALA213
3.760
TRP214
4.209
VAL216
2.943
ARG218
3.966
LEU219
3.717
ARG222
2.836
PHE223
3.989
VAL235
4.775
LEU238
4.132
VAL241
3.729
LEU250
3.414
LEU251
3.280
ALA254
3.549
ARG257
3.139
ALA258
3.787
LEU260
4.194
ILE264
4.061
LEU283
3.760
LEU284
3.881
SER287
2.555
ILE290
3.572
ALA291
3.956
ASP324
3.341
VAL325
4.958
LEU327
4.002
GLY328
3.147
LEU331
4.470
SER342
3.162
VAL344
3.625
LEU345
4.256
LEU347
4.151
ARG348
2.621
ALA350
3.863
LYS351
3.690
GLU354
4.283
PRO384
3.916
LEU387
4.019
ILE388
3.925
ASN391
3.926
CYS392
3.597
TYR401
2.525
PHE403
4.421
ASN405
3.233
LEU407
4.710
ARG410
4.054
TYR411
2.788
LYS414
4.655
VAL415
3.303
VAL418
3.451
LEU423
4.261
VAL426
3.770
LEU430
3.884
VAL433
3.978
GLY434
3.859
CYS437
4.247
CYS438
3.935
MET446
4.177
ALA449
4.330
GLU450
4.122
LEU453
3.682
LEU457
3.843
LEU460
3.323
VAL473
4.272
SER480
4.727
LEU481
4.005
VAL482
3.709
ARG485
2.706
PRO486
4.525
PHE488
3.425
SER489
2.374
PHE507
3.460
PHE509
4.348
LYS525
2.391
ALA528
3.879
LEU529
4.353
LEU532
4.402
VAL547
4.335
MET548
3.268
PHE551
3.381
ALA552
3.698
LEU575
4.018
VAL576
4.046
SER579
3.552
GLN580
4.965
|
|||||
| PDB ID: 3UIV Human serum albumin-myristate-amantadine hydrochloride complex | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [10] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:26 or .A:27 or .A:46 or .A:66 or .A:70 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:153 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:192 or .A:195 or .A:196 or .A:199 or .A:238 or .A:241 or .A:242 or .A:245 or .A:250 or .A:251 or .A:253 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:291 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.440
LEU14
4.073
LEU22
3.638
VAL23
3.669
ALA26
4.566
PHE27
4.834
VAL46
4.643
LEU66
3.488
PHE70
4.394
LEU115
4.257
VAL116
4.762
ARG117
3.021
PRO118
4.923
MET123
3.391
PHE134
4.676
LEU135
4.701
TYR138
3.261
LEU139
4.495
ILE142
4.386
TYR150
2.636
PRO152
3.663
GLU153
3.735
LEU154
4.035
PHE157
4.406
ALA158
3.637
TYR161
3.090
PHE165
4.038
LEU182
4.116
ARG186
3.767
SER192
3.745
LYS195
3.923
GLN196
3.494
LYS199
4.170
LEU238
3.548
VAL241
4.268
HIS242
3.076
CYS245
3.473
LEU250
4.639
LEU251
3.570
CYS253
4.296
ALA254
3.392
ARG257
2.833
ALA258
3.692
LEU283
3.924
LEU284
4.065
SER287
2.386
ALA291
3.893
SER342
2.863
VAL344
3.368
LEU345
4.117
ARG348
2.756
PRO384
4.152
LEU387
3.233
ILE388
3.446
ASN391
3.884
TYR401
3.137
ASN405
3.390
ARG410
4.152
TYR411
3.146
LYS414
4.980
VAL415
3.839
LEU423
4.683
VAL426
4.045
LEU430
4.266
VAL433
4.307
GLY434
4.539
CYS438
4.896
MET446
3.483
ALA449
3.965
GLU450
4.060
LEU453
3.755
LEU457
3.815
LEU460
3.700
ARG485
2.881
PRO486
4.286
PHE488
3.782
SER489
2.383
LEU491
4.695
PHE502
4.277
PHE507
3.553
PHE509
3.964
LYS525
3.295
ALA528
4.202
LEU529
4.138
LEU532
3.631
VAL547
3.688
MET548
3.612
PHE551
3.667
ALA552
4.187
LEU575
3.986
VAL576
4.210
SER579
3.914
GLN580
4.497
|
|||||
| PDB ID: 6WUW Crystal structure of Human Serum Albumin complex with JMS-053 | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [11] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:150 or .A:152 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:285 or .A:286 or .A:287 or .A:288 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:407 or .A:411 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:482 or .A:485 or .A:486 or .A:502 or .A:507 or .A:509 or .A:525 or .A:526 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.712
LEU14
3.910
PHE19
3.965
LEU22
3.731
VAL23
4.066
LEU66
4.573
TYR150
2.535
PRO152
3.686
ARG209
3.863
ALA210
4.110
LYS212
4.539
ALA213
3.882
VAL216
4.071
LEU250
3.837
LEU251
3.973
ALA254
3.211
ARG257
3.246
ALA258
3.592
LEU283
3.567
LEU284
3.539
GLU285
4.803
LYS286
4.287
SER287
2.596
HIS288
4.380
ASP324
3.705
LEU327
3.937
GLY328
3.924
LEU331
4.425
SER342
2.844
VAL344
3.408
LEU345
4.323
LEU347
4.312
ARG348
2.808
ALA350
4.096
LYS351
4.051
GLU354
3.933
PRO384
4.094
LEU387
3.900
ILE388
3.802
ASN391
3.778
CYS392
4.998
TYR401
2.690
PHE403
4.178
ASN405
3.742
LEU407
4.369
TYR411
4.664
LEU430
3.556
VAL433
3.789
GLY434
3.328
CYS438
4.491
MET446
4.078
ALA449
3.818
GLU450
3.870
LEU453
3.797
VAL482
4.671
ARG485
2.741
PRO486
4.449
PHE502
4.231
PHE507
3.874
PHE509
4.106
LYS525
3.441
GLN526
4.997
ALA528
3.726
LEU529
4.056
LEU532
3.929
HIS535
4.542
VAL547
3.983
MET548
3.820
PHE551
4.018
ALA552
4.040
LEU575
4.479
VAL576
4.312
SER579
3.717
GLN580
4.243
LEU583
4.285
|
|||||
| PDB ID: 7QFE Crystal structure of Human Serum albumin in complex with Gemfibrozil | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [12] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 L
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:26 or .A:27 or .A:66 or .A:70 or .A:150 or .A:152 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:403 or .A:407 or .A:411 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:485 or .A:486; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.204
LEU14
4.174
LEU22
3.651
VAL23
4.071
ALA26
4.450
PHE27
4.943
LEU66
4.103
PHE70
3.859
TYR150
2.618
PRO152
3.659
LEU250
4.436
LEU251
3.503
ALA254
3.674
ARG257
2.856
ALA258
3.764
LEU283
3.754
LEU284
3.567
SER287
2.378
SER342
3.047
VAL344
3.310
|
|||||
| PDB ID: 2BXP Human serum albumin complexed with myristate and phenylbutazone | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 L
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:198 or .A:199 or .A:202 or .A:206 or .A:209 or .A:210 or .A:211 or .A:212 or .A:213 or .A:214 or .A:216 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:454 or .A:457 or .A:460 or .A:473 or .A:480 or .A:481 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:579; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.444
LEU14
4.144
LEU22
4.180
VAL23
4.993
LEU115
4.284
VAL116
4.430
ARG117
3.182
MET123
3.536
PHE134
4.639
LEU135
4.112
TYR138
3.469
LEU139
3.538
ILE142
4.558
TYR150
2.524
PRO152
4.085
LEU154
3.655
PHE157
4.291
ALA158
3.725
TYR161
3.407
PHE165
4.158
LEU182
4.390
ARG186
3.850
LEU198
3.702
LYS199
4.117
SER202
4.095
PHE206
4.614
ARG209
3.988
ALA210
3.607
PHE211
4.157
LYS212
4.120
ALA213
3.730
TRP214
3.606
VAL216
4.357
LEU250
4.307
LEU251
4.435
ALA254
3.426
ARG257
2.828
ALA258
4.121
LEU283
4.177
LEU284
4.335
SER287
2.588
ASP324
3.821
LEU327
3.897
GLY328
4.045
LEU331
4.622
SER342
2.891
VAL344
3.320
LEU345
4.219
LEU347
4.066
ARG348
2.910
ALA350
3.918
LYS351
4.064
GLU354
4.654
PRO384
4.135
LEU387
3.980
ILE388
3.383
ASN391
3.525
TYR401
2.749
PHE403
4.480
ASN405
3.933
LEU407
4.110
ARG410
4.674
TYR411
3.147
LYS414
4.274
VAL415
3.528
VAL418
3.441
LEU423
3.924
VAL426
4.141
LEU430
3.931
VAL433
4.282
GLY434
4.035
MET446
3.764
ALA449
4.100
GLU450
3.979
LEU453
3.651
SER454
4.883
LEU457
4.070
LEU460
3.457
VAL473
4.102
SER480
4.556
LEU481
3.490
VAL482
4.031
ARG485
2.809
PRO486
4.569
PHE488
3.622
SER489
2.806
PHE507
4.194
PHE509
4.736
LYS525
3.108
ALA528
3.911
LEU529
4.022
LEU532
4.013
VAL547
3.880
MET548
3.507
PHE551
3.560
ALA552
4.321
LEU575
4.261
SER579
4.805
|
|||||
| PDB ID: 7VR9 Crystal structure of human serum albumin complex with aripiprazole and myristic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | No | [14] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCDKE 565 TCFAEEGKKL575 VAASQAAL
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:150 or .A:152 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:228 or .A:232 or .A:238 or .A:241 or .A:242 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:261 or .A:264 or .A:283 or .A:284 or .A:287 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.221
LEU14
3.661
PHE19
3.669
LEU22
3.867
VAL23
4.287
TYR150
2.648
PRO152
3.697
LYS199
4.142
ARG209
3.835
ALA210
3.541
LYS212
4.119
ALA213
3.864
TRP214
4.567
VAL216
3.721
ARG218
3.454
LEU219
3.318
ARG222
3.513
PHE223
4.554
PHE228
4.139
SER232
4.261
LEU238
3.769
VAL241
4.435
HIS242
3.331
LEU250
4.494
LEU251
3.805
ALA254
3.847
ARG257
3.345
ALA258
3.222
LEU260
3.672
ALA261
4.995
ILE264
4.105
LEU283
3.282
LEU284
4.069
SER287
2.683
ILE290
3.865
ALA291
3.592
ASP324
3.300
VAL325
4.431
LEU327
3.813
GLY328
4.072
LEU331
4.592
SER342
2.563
VAL344
3.280
LEU345
4.361
LEU347
4.132
ARG348
2.672
ALA350
3.707
LYS351
3.895
GLU354
4.008
PRO384
3.775
LEU387
3.511
ILE388
3.893
ASN391
3.610
TYR401
3.397
PHE403
4.587
ASN405
3.971
ARG410
3.522
TYR411
3.391
VAL415
4.842
LEU423
4.573
VAL426
4.203
LEU430
3.704
VAL433
3.752
GLY434
4.181
MET446
4.397
ALA449
3.843
GLU450
4.417
LEU453
3.590
LEU457
4.018
LEU460
3.794
VAL482
3.614
ARG485
2.913
PRO486
4.500
PHE488
3.574
SER489
2.838
LEU491
4.661
PHE502
4.297
PHE507
3.710
PHE509
4.131
LYS525
3.696
ALA528
4.189
LEU529
3.983
LEU532
4.684
VAL547
4.052
MET548
3.934
PHE551
3.559
ALA552
3.761
LEU575
4.211
VAL576
4.156
SER579
3.718
GLN580
4.734
|
|||||
| PDB ID: 1E7C HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID and the general anesthetic halothane | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [15] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:115 or .A:116 or .A:117 or .A:123 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:250 or .A:251 or .A:253 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.943
LEU14
4.026
PHE19
4.770
LEU22
3.994
VAL23
4.501
LEU66
3.980
LEU115
4.440
VAL116
4.794
ARG117
2.882
MET123
3.365
LEU135
4.196
TYR138
3.365
LEU139
3.722
ILE142
4.330
TYR150
2.804
PRO152
4.138
LEU154
4.575
PHE157
4.509
ALA158
3.935
TYR161
3.600
PHE165
4.414
LEU182
4.407
ARG186
3.951
LEU250
4.254
LEU251
3.814
CYS253
4.821
ALA254
3.250
ARG257
3.495
ALA258
4.108
LEU283
4.058
LEU284
3.651
SER287
2.669
SER342
2.785
VAL344
3.511
LEU345
4.439
ARG348
3.015
PRO384
3.987
LEU387
3.879
ILE388
3.612
ASN391
3.845
TYR401
3.089
PHE403
4.825
ASN405
4.112
ARG410
3.097
TYR411
2.954
VAL415
3.683
VAL418
4.531
LEU423
4.678
VAL426
4.584
LEU430
4.059
VAL433
4.949
GLY434
4.646
MET446
4.055
ALA449
4.270
GLU450
4.168
LEU453
3.807
LEU457
3.970
LEU460
3.699
ARG485
3.278
PRO486
4.853
PHE488
3.695
SER489
3.192
PHE502
3.582
PHE507
3.531
PHE509
4.540
LYS525
2.934
ALA528
4.203
LEU529
4.347
LEU532
3.895
HIS535
4.205
VAL547
3.932
MET548
3.633
PHE551
3.835
ALA552
4.026
VAL576
4.014
SER579
3.699
GLN580
4.496
LEU583
4.483
|
|||||
| PDB ID: 1HK4 HUMAN SERUM ALBUMIN COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid) | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [16] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:66 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:223 or .A:228 or .A:238 or .A:241 or .A:242 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:261 or .A:264 or .A:283 or .A:284 or .A:286 or .A:287 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.447
LEU14
4.252
LEU22
4.193
VAL23
4.484
LEU66
4.958
LEU115
4.610
VAL116
4.726
ARG117
2.878
PRO118
4.891
MET123
3.383
PHE134
4.604
LEU135
4.549
TYR138
3.396
LEU139
3.797
ILE142
4.309
TYR150
2.452
PRO152
3.960
LEU154
4.512
PHE157
4.605
ALA158
4.112
TYR161
3.465
PHE165
4.169
LEU182
4.511
ARG186
4.100
LYS199
3.703
ARG209
3.856
ALA210
3.530
LYS212
4.209
ALA213
3.696
TRP214
4.027
VAL216
3.970
ARG218
3.950
LEU219
3.477
PHE223
4.647
PHE228
4.862
LEU238
3.958
VAL241
4.993
HIS242
3.938
LEU250
4.836
LEU251
4.128
ALA254
3.618
ARG257
3.337
ALA258
4.123
LEU260
3.467
ALA261
4.850
ILE264
3.657
LEU283
3.853
LEU284
4.064
LYS286
4.908
SER287
2.885
ILE290
3.586
ALA291
3.808
ASP324
3.659
VAL325
4.851
LEU327
3.862
GLY328
3.907
LEU331
4.504
SER342
2.927
VAL344
3.769
LEU345
4.210
LEU347
4.073
ARG348
2.657
ALA350
4.098
LYS351
4.384
GLU354
4.701
PRO384
4.126
LEU387
3.657
ILE388
3.435
ASN391
4.735
TYR401
3.246
PHE403
4.216
ASN405
3.835
ARG410
4.307
TYR411
2.905
VAL415
3.687
VAL418
4.140
LEU423
4.024
VAL426
4.423
LEU430
3.765
VAL433
4.476
GLY434
4.375
MET446
3.951
ALA449
3.843
GLU450
4.353
LEU453
3.896
LEU457
4.232
LEU460
3.815
SER480
4.917
VAL482
4.353
ARG485
2.706
PRO486
4.524
PHE488
3.775
SER489
2.603
PHE502
3.551
PHE507
3.464
PHE509
4.717
LYS525
3.506
ALA528
4.089
LEU529
4.161
LEU532
3.834
HIS535
4.271
VAL547
4.271
MET548
3.827
PHE551
3.458
ALA552
3.877
LEU575
4.715
VAL576
4.479
SER579
4.226
GLN580
4.445
LEU583
4.784
|
|||||
| PDB ID: 2BXK Human serum albumin complexed with myristate, azapropazone and indomethacin | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKEEQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:232 or .A:250 or .A:251 or .A:254 or .A:255 or .A:257 or .A:258 or .A:283 or .A:284 or .A:286 or .A:287 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.993
ARG10
3.938
LEU14
4.191
PHE19
3.926
LEU22
4.011
VAL23
4.296
VAL46
4.970
LEU66
4.002
LEU115
3.898
VAL116
4.176
ARG117
2.987
MET123
3.345
PHE134
3.661
LEU135
3.991
TYR138
3.326
LEU139
4.006
ILE142
3.813
TYR150
2.616
PRO152
4.427
LEU154
4.532
PHE157
4.782
ALA158
4.163
TYR161
3.541
PHE165
3.581
LEU182
4.361
ARG186
3.628
ARG209
3.898
ALA210
3.717
LYS212
4.049
ALA213
3.913
VAL216
4.290
SER232
4.825
LEU250
4.743
LEU251
3.658
ALA254
3.472
ASP255
4.946
ARG257
3.470
ALA258
3.918
LEU283
3.744
LEU284
4.131
LYS286
4.499
SER287
2.762
ASP324
3.682
LEU327
3.726
GLY328
3.935
LEU331
4.366
SER342
2.975
VAL344
3.296
LEU345
4.371
LEU347
4.235
ARG348
2.658
ALA350
4.223
LYS351
4.348
GLU354
4.151
PRO384
4.183
LEU387
3.402
ILE388
3.613
ASN391
3.943
TYR401
2.972
PHE403
4.082
ASN405
3.963
LEU407
4.797
ARG410
3.319
TYR411
2.944
LYS414
4.743
VAL415
4.685
VAL418
4.445
LEU423
3.845
VAL426
4.145
LEU430
3.822
VAL433
4.942
MET446
4.173
ALA449
4.117
GLU450
4.484
LEU453
3.664
LEU457
4.252
LEU460
3.828
SER480
3.612
VAL482
4.577
ARG485
2.760
PRO486
4.503
PHE488
3.776
SER489
2.542
LEU491
4.937
PHE502
3.769
PHE507
3.560
PHE509
4.783
LYS525
3.454
ALA528
4.002
LEU529
4.201
LEU532
3.990
HIS535
4.539
VAL547
4.002
MET548
3.841
PHE551
3.454
ALA552
3.962
LEU575
4.166
VAL576
4.270
SER579
3.967
GLN580
3.825
|
|||||
| PDB ID: 2XVV Human serum albumin complexed with dansyl-L-asparagine and myristic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [17] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKEEQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:69 or .A:70 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.077
LEU14
4.039
PHE19
4.253
LEU22
4.485
VAL23
4.112
VAL46
4.455
LEU66
3.960
LEU69
4.747
PHE70
4.295
LEU115
4.313
VAL116
4.255
ARG117
2.962
PRO118
4.838
MET123
3.366
PHE134
4.439
LEU135
4.350
TYR138
3.499
LEU139
4.020
ILE142
4.264
TYR150
2.559
PRO152
4.524
LEU154
3.972
PHE157
3.679
ALA158
3.659
TYR161
3.613
PHE165
4.059
LEU182
4.277
ARG186
3.897
ARG209
3.696
ALA210
3.766
LYS212
4.141
ALA213
3.827
VAL216
4.431
LEU251
3.669
ALA254
3.485
ARG257
3.141
ALA258
4.363
LEU283
3.545
LEU284
3.588
SER287
2.957
ASP324
3.808
VAL325
4.956
LEU327
3.987
GLY328
4.074
LEU331
4.489
SER342
3.013
VAL344
3.685
LEU345
4.228
LEU347
4.224
ARG348
2.692
ALA350
4.205
LYS351
4.473
GLU354
4.272
PRO384
3.975
LEU387
3.732
ILE388
3.382
ASN391
4.268
TYR401
2.875
PHE403
4.818
ASN405
3.843
ARG410
4.114
TYR411
2.834
LYS414
4.605
VAL415
4.565
VAL418
4.596
LEU423
4.137
VAL426
4.507
LEU430
3.749
VAL433
4.362
GLY434
4.324
MET446
3.898
ALA449
4.149
GLU450
4.305
LEU453
3.790
LEU457
3.993
LEU460
4.009
SER480
3.629
VAL482
3.485
ARG485
2.791
PRO486
4.594
PHE488
3.744
SER489
2.559
LEU491
4.556
PHE502
4.478
PHE507
3.821
PHE509
4.949
LYS525
3.116
ALA528
4.134
LEU529
3.991
LEU532
3.975
HIS535
4.321
VAL547
3.702
MET548
3.652
PHE551
3.570
ALA552
4.273
LEU575
4.553
VAL576
4.197
SER579
3.649
GLN580
3.888
LEU583
4.804
|
|||||
| PDB ID: 8EW4 Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 1 | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [18] |
| PDB Sequence |
DAHKSEVAHR
10 FKDLGEENFK20 ALVLIAFAQY30 LQQCPFEDHV40 KLVNEVTEFA50 KTCVADESAE 60 NCDKSLHTLF70 GDKLCTVATL80 RETYGEMADC90 CAKQEPERNE100 CFLQHKDDNP 110 NLPRLVRPEV120 DVMCTAFHDN130 EETFLKKYLY140 EIARRHPYFY150 APELLFFAKR 160 YKAAFTECCQ170 AADKAACLLP180 KLDELRDEGK190 ASSAKQRLKC200 ASLQKFGERA 210 FKAWAVARLS220 QRFPKAEFAE230 VSKLVTDLTK240 VHTECCHGDL250 LECADDRADL 260 AKYICENQDS270 ISSKLKECCE280 KPLLEKSHCI290 AEVENDEMPA300 DLPSLAADFV 310 ESKDVCKNYA320 EAKDVFLGMF330 LYEYARRHPD340 YSVVLLLRLA350 KTYETTLEKC 360 CAAADPHECY370 AKVFDEFKPL380 VEEPQNLIKQ390 NCELFEQLGE400 YKFQNALLVR 410 YTKKVPQVST420 PTLVEVSRNL430 GKVGSKCCKH440 PEAKRMPCAE450 DYLSVVLNQL 460 CVLHEKTPVS470 DRVTKCCTES480 LVNRRPCFSA490 LEVDETYVPK500 EFNAETFTFH 510 ADICTLSEKE520 RQIKKQTALV530 ELVKHKPKAT540 KEQLKAVMDD550 FAAFVEKCCK 560 ADDKETCFAE570 EGKKLVAASQ580 AALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:30 or .A:66 or .A:67 or .A:70 or .A:99 or .A:108 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:146 or .A:148 or .A:149 or .A:150 or .A:152 or .A:153 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:185 or .A:186 or .A:189 or .A:190 or .A:193 or .A:195 or .A:196 or .A:197 or .A:198 or .A:199 or .A:200 or .A:202 or .A:204 or .A:206 or .A:209 or .A:210 or .A:211 or .A:212 or .A:213 or .A:214 or .A:215 or .A:216 or .A:219 or .A:222 or .A:223 or .A:235 or .A:238 or .A:241 or .A:242 or .A:245 or .A:246 or .A:247 or .A:248 or .A:249 or .A:250 or .A:251 or .A:253 or .A:254 or .A:257 or .A:260 or .A:264 or .A:284 or .A:287 or .A:290 or .A:291 or .A:293 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:402 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:427 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:451 or .A:453 or .A:454 or .A:457 or .A:460 or .A:480 or .A:481 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:536 or .A:547 or .A:548 or .A:551 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.140
LEU14
3.510
PHE19
4.352
LEU22
3.832
VAL23
3.374
ALA26
3.960
TYR30
3.322
LEU66
4.004
HIS67
3.613
PHE70
3.422
ASN99
3.615
ASP108
4.262
LEU115
4.389
VAL116
4.066
ARG117
3.216
PRO118
4.571
MET123
3.845
PHE134
4.637
LEU135
3.748
TYR138
3.668
LEU139
3.869
ILE142
3.397
HIS146
2.988
TYR148
3.221
PHE149
3.652
TYR150
3.363
PRO152
4.246
GLU153
4.085
LEU154
3.807
PHE157
4.311
ALA158
3.651
TYR161
3.405
PHE165
3.787
LEU182
4.385
LEU185
4.121
ARG186
3.136
GLY189
3.518
LYS190
3.374
SER193
3.732
LYS195
4.091
GLN196
3.349
ARG197
2.825
LEU198
4.276
LYS199
3.056
CYS200
4.254
SER202
3.618
GLN204
3.712
PHE206
4.848
ARG209
4.019
ALA210
3.479
PHE211
3.460
LYS212
3.455
ALA213
3.819
TRP214
3.405
ALA215
4.197
VAL216
3.308
LEU219
4.441
ARG222
4.438
PHE223
4.142
VAL235
4.596
LEU238
3.573
VAL241
3.476
HIS242
3.155
CYS245
3.607
CYS246
3.319
HIS247
4.419
GLY248
3.788
ASP249
3.093
LEU250
3.502
LEU251
3.427
CYS253
4.232
ALA254
3.218
ARG257
2.859
LEU260
4.043
ILE264
4.267
LEU284
3.550
SER287
4.017
ILE290
3.541
ALA291
3.845
VAL293
4.594
ASP324
3.541
VAL325
4.709
LEU327
3.625
GLY328
4.343
LEU331
4.207
SER342
2.965
VAL344
3.609
LEU345
4.094
LEU347
4.235
ARG348
2.836
ALA350
3.846
LYS351
3.787
GLU354
3.900
PRO384
3.829
LEU387
3.581
ILE388
3.536
ASN391
3.902
CYS392
4.749
TYR401
3.166
LYS402
4.828
PHE403
4.116
ASN405
3.932
LEU407
4.219
ARG410
3.506
TYR411
3.207
VAL415
3.728
VAL418
4.696
THR422
4.837
LEU423
3.587
VAL426
3.308
SER427
4.441
LEU430
3.823
VAL433
3.677
GLY434
3.652
CYS438
4.650
MET446
4.417
ALA449
4.149
GLU450
3.994
ASP451
5.000
LEU453
3.651
SER454
3.476
LEU457
4.052
LEU460
3.396
SER480
4.054
LEU481
4.244
VAL482
4.160
ARG485
2.805
PRO486
4.364
PHE488
3.790
SER489
3.215
LEU491
4.339
PHE502
4.219
PHE507
3.810
PHE509
4.413
LYS525
2.939
ALA528
4.092
LEU529
3.889
LEU532
3.664
HIS535
3.880
LYS536
4.908
VAL547
4.096
MET548
3.787
PHE551
3.459
LEU575
4.144
VAL576
4.178
SER579
3.729
GLN580
3.565
LEU583
4.729
|
|||||
| PDB ID: 1BJ5 HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [19] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:285 or .A:286 or .A:287 or .A:288 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:485 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.264
LEU14
4.040
PHE19
4.805
LEU22
4.111
VAL23
4.458
LEU66
3.855
LEU115
4.733
VAL116
4.722
ARG117
2.860
PRO118
4.899
MET123
3.422
PHE134
4.928
LEU135
3.909
TYR138
3.250
LEU139
4.085
ILE142
4.253
TYR150
2.795
PRO152
3.871
ALA158
4.001
TYR161
3.625
PHE165
4.217
LEU182
3.817
ARG186
4.106
LEU251
4.001
ALA254
3.486
ARG257
3.123
ALA258
3.950
LEU283
3.500
LEU284
4.029
GLU285
4.444
LYS286
4.825
SER287
2.357
HIS288
4.810
SER342
2.877
VAL344
3.582
LEU345
4.276
ARG348
2.559
PRO384
3.779
LEU387
3.436
ILE388
3.389
ASN391
4.072
TYR401
3.073
ASN405
3.985
ARG410
3.029
TYR411
2.775
VAL415
3.447
VAL418
4.845
LEU423
4.204
VAL426
4.096
LEU430
3.911
VAL433
3.927
GLY434
4.143
MET446
4.312
ALA449
4.177
GLU450
4.204
LEU453
3.478
LEU457
3.954
LEU460
3.578
VAL473
4.916
ARG485
3.097
PHE488
3.574
SER489
2.875
LEU491
4.981
PHE502
3.452
PHE507
3.129
LYS525
2.613
ALA528
4.176
LEU529
4.190
LEU532
4.094
HIS535
4.498
VAL547
3.826
MET548
3.619
PHE551
3.936
ALA552
3.842
VAL576
4.352
SER579
3.720
GLN580
4.358
LEU583
4.317
|
|||||
| PDB ID: 1E7G Human serum albumin complexed with tetradecanoic acid (myristic acid) | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [20] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:46 or .A:49 or .A:66 or .A:69 or .A:70 or .A:73 or .A:115 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:235 or .A:238 or .A:241 or .A:242 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:285 or .A:286 or .A:287 or .A:290 or .A:291 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.084
ARG10
4.115
LEU14
4.401
PHE19
3.302
LEU22
4.280
VAL23
3.939
ALA26
4.579
VAL46
3.588
PHE49
3.723
LEU66
3.555
LEU69
3.762
PHE70
3.438
LYS73
3.604
LEU115
4.750
ARG117
3.281
MET123
3.388
PHE134
4.597
LEU135
4.060
TYR138
3.560
LEU139
3.747
ILE142
4.132
TYR150
3.028
PRO152
3.903
LEU154
4.759
PHE157
4.759
ALA158
3.858
TYR161
3.488
PHE165
3.613
LEU182
3.839
ARG186
4.050
LYS199
3.357
ARG209
3.381
ALA210
3.423
LYS212
3.835
ALA213
3.801
TRP214
3.826
VAL216
4.019
ARG218
3.378
LEU219
3.997
ARG222
3.815
PHE223
4.739
VAL235
4.891
LEU238
3.549
VAL241
4.296
HIS242
3.713
LEU250
4.395
LEU251
3.389
ALA254
3.669
ARG257
3.223
ALA258
4.259
LEU260
4.031
ILE264
4.412
LEU283
3.117
LEU284
3.700
GLU285
4.713
LYS286
4.657
SER287
2.419
ILE290
3.802
ALA291
3.840
ASP324
4.011
LEU327
3.972
GLY328
4.131
LEU331
4.812
SER342
2.539
VAL344
3.058
LEU345
4.088
LEU347
4.214
ARG348
2.801
ALA350
4.055
LYS351
4.303
GLU354
3.933
PRO384
4.024
LEU387
3.213
ILE388
3.668
ASN391
4.060
TYR401
3.085
PHE403
4.903
ASN405
4.038
ARG410
3.085
TYR411
3.054
VAL415
3.805
VAL418
4.797
LEU423
4.695
VAL426
4.521
LEU430
4.034
VAL433
4.305
GLY434
3.886
MET446
4.262
ALA449
4.120
GLU450
4.243
LEU453
3.704
LEU457
3.950
LEU460
3.680
VAL482
4.970
ARG485
2.802
PRO486
4.812
PHE488
3.601
SER489
3.034
LEU491
4.756
PHE502
3.924
PHE507
3.407
PHE509
4.468
LYS525
2.955
ALA528
4.043
LEU529
4.220
LEU532
3.938
HIS535
4.410
VAL547
4.075
MET548
3.690
PHE551
3.868
ALA552
3.834
VAL576
4.239
SER579
4.008
GLN580
4.240
LEU583
4.180
|
|||||
| PDB ID: 1H9Z Human Serum Albumin Complexed With Myristic Acid and the R-(+) enantiomer of warfarin | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [21] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LGL
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:70 or .A:115 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:261 or .A:283 or .A:284 or .A:286 or .A:287 or .A:288 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:437 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:536 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.696
ARG10
4.536
LEU14
4.001
PHE19
4.617
LEU22
3.817
VAL23
4.149
VAL46
4.823
LEU66
3.503
PHE70
4.632
LEU115
4.227
ARG117
2.889
MET123
3.362
PHE134
4.354
LEU135
4.138
TYR138
3.275
LEU139
3.759
ILE142
3.847
TYR150
2.531
PRO152
4.366
LEU154
4.655
PHE157
4.536
ALA158
3.553
TYR161
3.268
PHE165
3.673
LEU182
4.199
ARG186
4.127
ARG209
3.594
ALA210
4.110
LYS212
4.456
ALA213
4.029
VAL216
4.519
LEU250
4.906
LEU251
3.646
ALA254
3.549
ARG257
3.410
ALA258
4.118
ALA261
4.994
LEU283
4.001
LEU284
3.992
LYS286
4.980
SER287
2.572
HIS288
4.898
ASP324
3.658
VAL325
4.998
LEU327
3.936
GLY328
4.054
LEU331
4.665
SER342
2.954
VAL344
3.735
LEU345
4.292
LEU347
3.962
ARG348
2.593
ALA350
4.191
LYS351
3.801
GLU354
4.330
PRO384
4.182
LEU387
3.882
ILE388
3.387
ASN391
3.951
CYS392
4.055
TYR401
2.650
PHE403
4.887
ASN405
3.907
ARG410
3.956
TYR411
2.940
LYS414
4.008
VAL415
3.475
VAL418
3.584
THR422
3.923
LEU423
3.643
VAL426
3.639
LEU430
4.268
VAL433
3.765
GLY434
3.644
CYS437
4.184
CYS438
3.696
MET446
4.101
ALA449
3.941
GLU450
4.153
LEU453
3.808
LEU457
3.673
LEU460
3.577
VAL482
4.411
ARG485
2.747
PRO486
4.473
PHE488
3.811
SER489
2.532
PHE502
3.961
PHE507
3.861
PHE509
4.241
LYS525
3.234
ALA528
3.691
LEU529
3.901
LEU532
4.134
HIS535
4.704
LYS536
4.386
VAL547
3.903
MET548
4.013
PHE551
3.503
ALA552
3.888
LEU575
4.731
VAL576
4.273
SER579
3.560
GLN580
3.727
LEU583
4.779
|
|||||
| PDB ID: 1HA2 Human Serum Albumin Complexed With Myristic Acid and the S-(-) enantiomer of warfarin | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [21] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LGL
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:70 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:251 or .A:254 or .A:257 or .A:258 or .A:261 or .A:283 or .A:284 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:437 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.889
ARG10
4.448
LEU14
3.978
PHE19
4.744
LEU22
4.159
VAL23
4.077
VAL46
4.589
LEU66
3.559
PHE70
4.688
LEU115
4.516
VAL116
4.627
ARG117
3.014
MET123
3.381
PHE134
4.543
LEU135
3.912
TYR138
3.307
LEU139
3.756
ILE142
4.202
TYR150
2.641
PRO152
4.133
LEU154
4.418
PHE157
4.220
ALA158
3.545
TYR161
3.508
PHE165
4.130
LEU182
4.289
ARG186
4.005
ARG209
3.545
ALA210
3.777
LYS212
4.453
ALA213
4.072
VAL216
4.161
PHE228
4.657
SER232
4.799
LEU251
3.671
ALA254
3.620
ARG257
3.252
ALA258
4.243
ALA261
4.942
LEU283
3.759
LEU284
3.889
SER287
2.501
ASP324
3.795
VAL325
4.711
LEU327
3.839
GLY328
3.868
LEU331
4.273
SER342
2.852
VAL344
3.597
LEU345
4.211
LEU347
4.022
ARG348
2.476
ALA350
4.198
LYS351
4.066
GLU354
3.859
PRO384
4.003
LEU387
3.839
ILE388
3.404
ASN391
3.639
CYS392
4.215
TYR401
2.746
PHE403
4.332
ASN405
3.639
ARG410
4.172
TYR411
2.975
LYS414
4.870
VAL415
3.447
VAL418
3.302
THR422
4.052
LEU423
3.970
VAL426
4.315
LEU430
4.011
VAL433
3.945
GLY434
3.549
CYS437
4.666
CYS438
4.451
MET446
3.941
ALA449
4.158
GLU450
3.998
LEU453
3.937
LEU457
3.727
LEU460
3.546
SER480
4.896
VAL482
4.792
ARG485
2.797
PRO486
4.548
PHE488
3.882
SER489
2.656
PHE502
3.726
PHE507
3.634
PHE509
4.735
LYS525
2.974
ALA528
3.966
LEU529
4.076
LEU532
3.724
HIS535
4.125
VAL547
3.985
MET548
4.123
PHE551
3.582
ALA552
4.707
LEU575
4.977
VAL576
4.204
SER579
3.630
GLN580
4.066
LEU583
4.355
|
|||||
| PDB ID: 2BXI Human serum albumin complexed with myristate and azapropazone | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKEEQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:150 or .A:152 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:232 or .A:250 or .A:251 or .A:254 or .A:255 or .A:257 or .A:258 or .A:261 or .A:283 or .A:284 or .A:286 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.943
LEU14
4.085
LEU22
4.055
TYR150
2.975
PRO152
4.507
ARG209
3.594
ALA210
4.157
LYS212
4.407
ALA213
4.059
VAL216
4.253
SER232
4.832
LEU250
4.838
LEU251
4.012
ALA254
3.609
ASP255
4.975
ARG257
3.625
ALA258
3.822
ALA261
4.832
LEU283
3.215
LEU284
3.707
LYS286
4.428
SER287
2.732
ASP324
3.633
VAL325
4.748
LEU327
3.834
GLY328
4.049
LEU331
4.522
SER342
2.681
VAL344
3.648
LEU345
4.190
LEU347
4.076
ARG348
2.546
ALA350
4.073
LYS351
4.094
GLU354
4.069
PRO384
4.058
LEU387
3.546
ILE388
3.341
ASN391
4.307
TYR401
2.850
PHE403
4.213
ASN405
3.373
ARG410
3.942
TYR411
3.082
LYS414
4.391
VAL415
4.588
VAL418
4.935
LEU423
4.734
VAL426
4.903
LEU430
4.042
VAL433
4.418
GLY434
4.054
MET446
3.989
ALA449
3.872
GLU450
4.334
LEU453
3.825
LEU457
3.692
LEU460
4.154
SER480
3.522
VAL482
4.557
ARG485
2.792
PRO486
4.562
PHE488
3.790
SER489
2.615
LEU491
4.677
PHE507
3.696
PHE509
4.618
LYS525
3.297
ALA528
4.105
LEU529
3.862
LEU532
4.171
VAL547
4.101
MET548
3.758
PHE551
3.849
ALA552
4.141
LEU575
4.761
VAL576
4.491
SER579
4.205
|
|||||
| PDB ID: 2BXM Human serum albumin complexed with myristate and indomethacin | ||||||
| Method | X-ray diffraction | Resolution | 2.50 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:66 or .A:70 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:219 or .A:222 or .A:223 or .A:228 or .A:232 or .A:238 or .A:241 or .A:242 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:286 or .A:287 or .A:288 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:437 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.382
LEU14
3.995
PHE19
4.998
LEU22
3.884
VAL23
4.544
ALA26
4.796
LEU66
4.243
PHE70
4.071
LEU115
4.104
VAL116
4.926
ARG117
2.843
MET123
3.489
PHE134
4.574
LEU135
4.040
TYR138
3.286
LEU139
3.539
ILE142
4.325
TYR150
2.647
PRO152
4.176
LEU154
4.393
PHE157
4.225
ALA158
3.788
TYR161
3.420
PHE165
3.791
LEU182
4.154
ARG186
3.584
ARG209
3.650
ALA210
3.738
LYS212
4.424
ALA213
3.999
VAL216
3.923
LEU219
3.874
ARG222
4.655
PHE223
4.791
PHE228
4.374
SER232
4.141
LEU238
4.241
VAL241
4.777
HIS242
3.645
LEU250
4.845
LEU251
3.768
ALA254
3.469
ARG257
3.264
ALA258
4.250
LEU260
3.863
ILE264
4.271
LEU283
3.689
LEU284
3.958
LYS286
4.789
SER287
2.491
HIS288
4.828
ILE290
3.661
ALA291
3.820
ASP324
3.885
VAL325
4.958
LEU327
4.014
GLY328
3.941
LEU331
4.287
SER342
3.167
VAL344
3.619
LEU345
4.434
LEU347
4.045
ARG348
2.782
ALA350
4.054
LYS351
2.804
GLU354
4.296
PRO384
3.828
LEU387
3.997
ILE388
3.427
ASN391
3.750
CYS392
4.151
TYR401
3.015
PHE403
4.300
ASN405
3.811
ARG410
4.044
TYR411
2.942
LYS414
4.261
VAL415
3.731
VAL418
3.450
THR422
3.763
LEU423
3.716
VAL426
4.100
LEU430
3.986
VAL433
3.885
GLY434
3.624
CYS437
4.733
CYS438
4.153
MET446
4.219
ALA449
3.946
GLU450
4.105
LEU453
3.939
LEU457
3.769
LEU460
3.357
ARG485
2.910
PRO486
4.614
PHE488
3.644
SER489
2.646
LEU491
4.978
PHE502
3.880
PHE507
3.505
PHE509
4.167
LYS525
3.220
ALA528
4.071
LEU529
4.244
LEU532
3.987
HIS535
4.003
VAL547
3.719
MET548
3.672
PHE551
3.594
ALA552
4.044
LEU575
4.716
VAL576
4.642
SER579
3.973
GLN580
3.832
LEU583
4.456
|
|||||
| PDB ID: 2BXL Human serum albumin complexed with myristate and 3,5-diiodosalicylic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 L
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:115 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.996
LEU14
4.181
PHE19
4.922
LEU22
4.538
VAL23
4.424
LEU66
4.775
LEU115
4.422
ARG117
2.824
MET123
4.000
PHE134
4.534
LEU135
3.656
TYR138
3.351
LEU139
4.433
ILE142
4.761
TYR150
3.113
PRO152
4.484
PHE157
4.976
ALA158
3.790
TYR161
3.521
PHE165
3.852
LEU182
3.892
ARG186
4.240
ARG209
3.407
ALA210
4.272
LYS212
4.416
ALA213
3.924
VAL216
4.015
LEU251
4.051
ALA254
3.497
ARG257
3.307
ALA258
3.930
LEU283
3.645
LEU284
3.560
SER287
2.620
ASP324
3.925
LEU327
3.954
GLY328
3.985
LEU331
4.624
SER342
2.708
VAL344
3.886
LEU345
4.202
LEU347
4.142
ARG348
2.870
ALA350
3.958
LYS351
4.106
GLU354
4.189
PRO384
3.814
LEU387
3.340
ILE388
3.515
ASN391
3.831
TYR401
3.141
PHE403
4.918
ASN405
4.029
ARG410
4.348
TYR411
3.330
LYS414
4.807
VAL415
4.942
VAL418
4.475
LEU423
4.485
VAL426
4.494
LEU430
3.831
VAL433
4.513
GLY434
4.426
MET446
4.097
ALA449
4.144
GLU450
4.430
LEU453
3.649
LEU457
4.223
LEU460
3.543
SER480
3.926
VAL482
4.651
ARG485
3.042
PRO486
4.831
PHE488
3.482
SER489
2.750
LEU491
4.851
PHE502
3.827
PHE507
3.681
PHE509
4.187
LYS525
3.572
ALA528
4.133
LEU529
4.127
LEU532
3.893
HIS535
4.781
VAL547
3.951
MET548
3.742
PHE551
3.603
ALA552
4.083
LEU575
4.791
VAL576
4.516
SER579
4.075
GLN580
3.947
LEU583
4.876
|
|||||
| PDB ID: 2BXO Human serum albumin complexed with myristate and oxyphenbutazone | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:232 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.424
LEU14
4.097
PHE19
4.275
LEU22
3.875
VAL23
4.408
LEU66
4.710
LEU115
4.987
VAL116
4.844
ARG117
3.145
MET123
3.454
PHE134
4.868
LEU135
4.511
TYR138
3.486
LEU139
3.889
ILE142
4.002
TYR150
2.616
PRO152
4.518
LEU154
4.862
PHE157
4.438
ALA158
3.674
TYR161
3.367
PHE165
3.784
LEU182
4.390
ARG186
3.900
ARG209
3.560
ALA210
3.781
LYS212
4.376
ALA213
3.968
VAL216
3.898
SER232
4.924
LEU251
3.977
ALA254
3.339
ARG257
3.095
ALA258
4.378
LEU283
3.750
LEU284
3.918
SER287
3.004
ASP324
3.886
LEU327
3.734
GLY328
3.933
LEU331
4.231
SER342
2.814
VAL344
3.509
LEU345
4.282
LEU347
3.941
ARG348
2.662
ALA350
4.276
LYS351
4.128
GLU354
4.079
PRO384
3.996
LEU387
3.674
ILE388
3.410
ASN391
4.169
TYR401
3.225
PHE403
4.129
ASN405
3.673
LEU407
4.957
ARG410
4.085
TYR411
2.918
LYS414
4.591
VAL415
3.707
VAL418
4.293
LEU423
4.128
VAL426
4.419
LEU430
3.754
GLY434
4.723
MET446
3.950
ALA449
4.064
GLU450
4.142
LEU453
3.602
LEU457
3.995
LEU460
3.900
VAL482
4.694
ARG485
2.990
PRO486
4.647
PHE488
3.707
SER489
2.658
LEU491
4.953
PHE502
4.135
PHE507
3.553
PHE509
4.847
LYS525
3.216
ALA528
4.091
LEU529
4.232
LEU532
3.776
HIS535
4.033
VAL547
3.813
MET548
3.956
PHE551
3.581
ALA552
4.508
LEU575
4.160
VAL576
4.122
SER579
4.182
GLN580
3.667
LEU583
4.314
|
|||||
| PDB ID: 2BXQ Human serum albumin complexed with myristate, phenylbutazone and indomethacin | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKEEQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:70 or .A:115 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.344
LEU14
3.952
PHE19
3.943
LEU22
4.067
VAL23
3.880
LEU66
3.736
PHE70
4.991
LEU115
4.243
ARG117
2.902
PRO118
4.909
MET123
3.439
PHE134
4.638
LEU135
4.423
TYR138
3.310
LEU139
3.875
ILE142
4.429
TYR150
2.681
PRO152
4.616
LEU154
4.427
PHE157
4.094
ALA158
3.670
TYR161
3.605
PHE165
3.955
LEU182
4.243
ARG186
4.077
ARG209
3.543
ALA210
4.695
LYS212
4.569
ALA213
3.932
VAL216
4.191
LEU250
4.355
LEU251
3.711
ALA254
3.651
ARG257
2.719
ALA258
4.548
LEU283
3.660
LEU284
3.833
SER287
2.553
ASP324
3.493
LEU327
3.970
GLY328
3.809
LEU331
4.408
SER342
3.183
VAL344
3.585
LEU345
4.385
LEU347
4.055
ARG348
2.711
ALA350
3.862
LYS351
3.680
GLU354
4.560
PRO384
3.984
LEU387
3.630
ILE388
3.410
ASN391
4.154
TYR401
3.051
PHE403
4.654
ASN405
3.655
ARG410
3.839
TYR411
2.932
LYS414
4.519
VAL415
4.756
VAL418
4.644
LEU423
4.342
VAL426
4.446
LEU430
4.292
VAL433
4.833
GLY434
3.820
CYS438
4.680
MET446
4.162
ALA449
4.186
GLU450
4.258
LEU453
3.902
LEU457
4.133
LEU460
4.012
SER480
3.347
VAL482
4.571
ARG485
2.942
PRO486
4.569
PHE488
3.766
SER489
2.626
LEU491
4.968
PHE502
3.967
PHE507
3.696
PHE509
4.923
LYS525
3.513
ALA528
3.801
LEU529
3.985
LEU532
4.013
HIS535
4.630
VAL547
3.969
MET548
3.655
PHE551
3.537
ALA552
3.711
LEU575
4.488
VAL576
4.440
SER579
3.586
GLN580
3.948
LEU583
4.939
|
|||||
| PDB ID: 3B9L Human serum albumin complexed with myristate and AZT | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [22] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:27 or .A:46 or .A:66 or .A:70 or .A:115 or .A:117 or .A:123 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:155 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:199 or .A:209 or .A:210 or .A:211 or .A:212 or .A:213 or .A:214 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:228 or .A:232 or .A:238 or .A:242 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:261 or .A:264 or .A:283 or .A:284 or .A:287 or .A:288 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:348 or .A:351 or .A:384 or .A:387 or .A:388 or .A:390 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:431 or .A:433 or .A:434 or .A:446 or .A:449 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:549 or .A:551 or .A:552 or .A:576 or .A:579 or .A:580; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.232
LEU14
3.924
PHE19
4.969
LEU22
3.997
VAL23
4.114
ALA26
4.998
PHE27
4.578
VAL46
3.948
LEU66
3.432
PHE70
3.919
LEU115
4.975
ARG117
2.983
MET123
3.561
LEU135
4.561
TYR138
3.483
LEU139
3.150
ILE142
4.099
TYR150
3.019
PRO152
3.986
LEU154
3.051
LEU155
4.492
PHE157
4.744
ALA158
3.173
TYR161
3.799
PHE165
4.239
LEU182
4.782
ARG186
3.102
LYS199
3.570
ARG209
3.757
ALA210
4.094
PHE211
4.006
LYS212
4.800
ALA213
3.529
TRP214
3.391
VAL216
4.638
ARG218
3.671
LEU219
4.044
ARG222
3.480
PHE223
4.806
PHE228
4.631
SER232
3.104
LEU238
3.238
HIS242
2.343
LEU250
4.638
LEU251
3.651
ALA254
3.386
ARG257
3.114
ALA258
3.919
LEU260
3.588
ALA261
3.365
ILE264
3.697
LEU283
3.957
LEU284
4.125
SER287
2.624
HIS288
4.920
ILE290
3.551
ALA291
3.984
ASP324
2.914
VAL325
4.576
LEU327
4.044
GLY328
3.451
LEU331
4.981
SER342
3.340
VAL344
2.931
LEU345
3.336
ARG348
2.531
LYS351
4.155
PRO384
3.687
LEU387
2.736
ILE388
3.405
GLN390
3.878
ASN391
2.417
TYR401
3.209
PHE403
3.047
ASN405
4.253
LEU407
3.140
TYR411
3.107
VAL415
3.462
VAL418
3.261
LEU423
3.371
VAL426
4.525
LEU430
2.905
GLY431
3.428
VAL433
4.773
GLY434
3.920
MET446
3.903
ALA449
3.725
LEU453
3.651
LEU457
4.272
LEU460
3.319
SER480
4.681
VAL482
4.532
ARG485
3.065
PRO486
4.495
PHE488
3.572
SER489
3.179
PHE502
4.475
PHE507
3.395
LYS525
3.290
ALA528
3.854
LEU529
3.746
LEU532
3.636
VAL547
4.109
MET548
3.323
ASP549
4.267
PHE551
3.847
ALA552
3.708
VAL576
3.839
SER579
4.099
GLN580
3.071
|
|||||
| PDB ID: 3TDL Structure of human serum albumin in complex with DAUDA | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [23] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKET 566 CFAEEGKKLV576 AASQAALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:70 or .A:150 or .A:151 or .A:152 or .A:250 or .A:251 or .A:254 or .A:255 or .A:257 or .A:258 or .A:283 or .A:284 or .A:285 or .A:287 or .A:288 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:415 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.690
ARG10
3.365
LEU14
3.823
PHE19
3.392
LEU22
3.442
VAL23
3.625
LEU66
3.288
PHE70
4.198
TYR150
2.523
ALA151
4.946
PRO152
3.678
LEU250
3.570
LEU251
3.681
ALA254
2.982
ASP255
4.740
ARG257
3.075
ALA258
4.061
LEU283
3.049
LEU284
2.770
GLU285
4.971
SER287
2.137
HIS288
4.585
SER342
2.632
VAL344
3.782
LEU345
4.412
ARG348
2.637
PRO384
3.938
LEU387
3.978
ILE388
3.850
ASN391
3.388
CYS392
4.323
TYR401
2.933
PHE403
4.266
ASN405
3.343
LEU407
4.475
ARG410
4.878
TYR411
3.234
VAL415
3.988
LEU423
4.347
VAL426
3.969
LEU430
3.522
VAL433
4.105
GLY434
3.885
CYS438
4.420
MET446
4.008
ALA449
3.737
GLU450
3.969
LEU453
3.115
LEU457
3.754
LEU460
3.846
ARG485
2.407
PRO486
4.604
PHE488
3.069
SER489
3.499
LEU491
4.908
PHE507
3.599
PHE509
4.343
LYS525
2.723
ALA528
3.643
LEU529
3.787
LEU532
3.569
VAL547
4.026
MET548
3.583
PHE551
3.533
ALA552
3.460
LEU575
3.615
VAL576
3.611
SER579
3.531
GLN580
4.611
|
|||||
| PDB ID: 2BXN Human serum albumin complexed with myristate and iodipamide | ||||||
| Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [13] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:66 or .A:70 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:285 or .A:286 or .A:287 or .A:288 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.424
LEU14
4.070
LEU22
4.051
VAL23
4.199
LEU66
4.020
PHE70
3.979
LEU115
4.488
VAL116
4.879
ARG117
2.887
MET123
3.708
PHE134
4.760
LEU135
4.432
TYR138
3.413
LEU139
3.854
ILE142
4.364
TYR150
2.603
PRO152
4.358
LEU154
4.730
PHE157
4.458
ALA158
3.804
TYR161
3.494
PHE165
3.907
LEU182
4.494
ARG186
4.082
ARG209
3.360
ALA210
4.165
LYS212
4.349
ALA213
4.245
VAL216
4.265
PHE228
4.177
SER232
4.312
LEU250
4.830
LEU251
4.245
ALA254
4.023
ARG257
3.439
ALA258
4.206
LEU283
3.623
LEU284
3.156
GLU285
4.715
LYS286
4.739
SER287
2.800
HIS288
4.381
ASP324
3.676
VAL325
4.963
LEU327
3.922
GLY328
4.088
LEU331
4.251
SER342
2.783
VAL344
3.538
LEU345
4.420
LEU347
3.613
ARG348
2.803
ALA350
3.970
LYS351
3.999
GLU354
4.815
PRO384
4.226
LEU387
3.692
ILE388
3.509
ASN391
4.089
TYR401
3.070
PHE403
4.636
ASN405
3.412
ARG410
3.873
TYR411
2.883
LYS414
4.033
VAL415
3.854
VAL418
4.311
LEU423
4.213
VAL426
4.195
LEU430
4.212
VAL433
4.490
GLY434
4.567
MET446
4.060
ALA449
4.278
GLU450
4.262
LEU453
3.841
LEU457
3.938
LEU460
3.704
VAL482
4.078
ARG485
2.879
PRO486
4.676
PHE488
3.726
SER489
2.526
PHE502
4.192
PHE507
3.602
PHE509
4.544
LYS525
2.908
ALA528
3.874
LEU529
4.267
LEU532
3.972
HIS535
4.918
VAL547
4.370
MET548
4.050
PHE551
3.559
ALA552
3.974
LEU575
4.437
VAL576
4.343
SER579
4.080
GLN580
3.951
LEU583
4.601
|
|||||
| PDB ID: 2XVW Human serum albumin complexed with dansyl-L-arginine and myristic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.65 Å | Mutation | No | [17] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKEEQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:114 or .A:115 or .A:116 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.195
LEU14
3.875
PHE19
4.479
LEU22
4.009
VAL23
4.271
LEU66
3.730
ARG114
4.580
LEU115
4.356
VAL116
4.669
ARG117
3.116
MET123
3.770
PHE134
4.792
LEU135
4.352
TYR138
3.643
LEU139
3.867
ILE142
4.482
TYR150
2.693
PRO152
4.414
LEU154
4.689
PHE157
4.523
ALA158
3.822
TYR161
3.543
PHE165
3.927
LEU182
4.562
ARG186
4.145
ARG209
3.715
ALA210
4.135
LYS212
4.301
ALA213
4.021
VAL216
4.122
PHE228
4.995
LEU251
3.724
ALA254
3.617
ARG257
3.091
ALA258
4.448
LEU283
3.664
LEU284
3.967
SER287
2.885
ASP324
4.002
VAL325
4.518
LEU327
3.972
GLY328
4.043
LEU331
3.953
SER342
2.700
VAL344
3.636
LEU345
4.268
LEU347
4.047
ARG348
2.669
ALA350
3.991
LYS351
4.016
GLU354
4.562
PRO384
4.145
LEU387
3.736
ILE388
3.583
ASN391
4.016
TYR401
3.151
PHE403
4.630
ASN405
3.529
ARG410
3.787
TYR411
2.899
LYS414
4.387
VAL415
4.898
VAL418
4.653
LEU423
4.394
VAL426
4.494
LEU430
3.730
VAL433
4.619
GLY434
4.608
MET446
4.049
ALA449
4.128
GLU450
4.112
LEU453
3.753
LEU457
4.096
LEU460
3.957
SER480
3.857
VAL482
4.135
ARG485
2.784
PRO486
4.608
PHE488
3.836
SER489
2.580
PHE502
4.735
PHE507
3.437
PHE509
4.538
LYS525
3.703
ALA528
3.847
LEU529
4.158
LEU532
4.014
VAL547
3.813
MET548
3.737
PHE551
3.395
ALA552
4.109
LEU575
4.469
VAL576
4.596
SER579
3.593
GLN580
4.205
LEU583
4.532
|
|||||
| PDB ID: 1HK5 HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid) | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [16] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVAHLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:115 or .A:116 or .A:117 or .A:123 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:199 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:232 or .A:238 or .A:242 or .A:251 or .A:254 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:285 or .A:287 or .A:288 or .A:290 or .A:291 or .A:293 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.442
LEU14
3.978
LEU22
3.993
VAL23
4.455
LEU115
4.608
VAL116
4.788
ARG117
3.023
MET123
4.266
LEU135
4.836
TYR138
3.542
LEU139
4.437
ILE142
4.432
TYR150
2.427
PRO152
4.296
LEU154
4.868
PHE157
4.565
ALA158
3.896
TYR161
3.485
PHE165
4.207
LEU182
4.388
ARG186
4.219
LYS199
4.741
ARG209
3.664
ALA210
3.623
LYS212
4.244
ALA213
3.838
VAL216
4.060
HIS218
2.966
LEU219
3.714
ARG222
3.310
PHE223
4.559
SER232
4.703
LEU238
4.072
HIS242
4.851
LEU251
3.932
ALA254
3.583
ARG257
3.229
ALA258
4.361
LEU260
4.001
ILE264
4.169
LEU283
3.695
LEU284
3.737
GLU285
4.915
SER287
2.492
HIS288
4.918
ILE290
3.763
ALA291
2.967
VAL293
4.946
ASP324
3.803
VAL325
4.920
LEU327
4.085
GLY328
3.823
LEU331
4.463
SER342
2.932
VAL344
3.720
LEU345
4.331
LEU347
4.115
ARG348
2.815
ALA350
4.223
LYS351
4.448
GLU354
4.263
PRO384
3.912
LEU387
3.708
ILE388
3.520
ASN391
4.486
TYR401
2.911
PHE403
4.404
ASN405
3.546
ARG410
3.806
TYR411
3.332
VAL415
3.907
VAL418
4.399
LEU423
4.062
VAL426
4.507
LEU430
3.778
VAL433
4.640
GLY434
4.466
MET446
3.967
ALA449
4.039
GLU450
4.251
LEU453
3.962
LEU457
4.196
LEU460
3.930
VAL482
4.695
ARG485
2.866
PRO486
4.714
PHE488
3.668
SER489
2.469
PHE502
3.797
PHE507
3.528
PHE509
4.765
LYS525
3.063
ALA528
3.880
LEU529
4.050
LEU532
4.029
HIS535
4.022
VAL547
4.072
MET548
3.837
PHE551
3.527
ALA552
3.832
LEU575
4.974
VAL576
4.623
SER579
3.835
GLN580
4.056
LEU583
4.495
|
|||||
| PDB ID: 2I2Z Human serum albumin complexed with myristate and aspirin | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | Yes | [24] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLCASL203 QKFGERAFKA 213 WAVARLSQRF223 PKAEFAEVSK233 LVTDLTKVHT243 ECCHGDLLEC253 ADDRADLAKY 263 ICENQDSISS273 KLKECCEKPL283 LEKSHCIAEV293 ENDEMPADLP303 SLAADFVESK 313 DVCKNYAEAK323 DVFLGMFLYE333 YARRHPDYSV343 VLLLRLAKTY353 ETTLEKCCAA 363 ADPHECYAKV373 FDEFKPLVEE383 PQNLIKQNCE393 LFEQLGEYKF403 QNALLVRYTK 413 KVPQVSTPTL423 VEVSRNLGKV433 GSKCCKHPEA443 KRMPCAEDYL453 SVVLNQLCVL 463 HEKTPVSDRV473 TKCCTESLVN483 RRPCFSALEV493 DETYVPKEFN503 AETFTFHADI 513 CTLSEKERQI523 KKQTALVELV533 KHKPKATKEQ543 LKAVMDDFAA553 FVEKCCKADD 563 KETCFAEEGK573 KLVAASQAAL583 G
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:115 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:261 or .A:283 or .A:284 or .A:286 or .A:287 or .A:288 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:422 or .A:423 or .A:426 or .A:427 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.636
LEU14
3.843
PHE19
3.452
LEU22
4.117
VAL23
3.551
LEU66
4.367
LEU115
4.842
ARG117
3.320
MET123
3.430
PHE134
4.238
LEU135
3.811
TYR138
3.188
LEU139
4.001
ILE142
3.929
TYR150
2.817
PRO152
4.372
LEU154
3.738
PHE157
3.990
ALA158
3.631
TYR161
3.524
PHE165
3.564
LEU182
4.277
ARG186
4.422
LEU250
3.781
LEU251
4.391
ALA254
3.646
ARG257
3.654
ALA258
4.132
ALA261
4.785
LEU283
3.856
LEU284
3.768
LYS286
4.675
SER287
2.624
HIS288
4.731
SER342
3.034
VAL344
3.712
LEU345
4.419
ARG348
2.698
PRO384
4.003
LEU387
3.700
ILE388
3.575
ASN391
3.610
CYS392
4.966
TYR401
2.829
PHE403
4.893
ASN405
4.137
ARG410
3.257
TYR411
2.814
VAL415
3.751
THR422
4.343
LEU423
3.090
VAL426
3.213
SER427
3.261
LEU430
3.175
VAL433
3.501
GLY434
4.321
CYS438
4.999
MET446
4.239
ALA449
4.339
GLU450
4.253
LEU453
3.395
LEU457
3.615
LEU460
3.701
VAL473
4.909
ARG485
2.886
PRO486
4.502
PHE488
3.709
SER489
2.569
LEU491
4.561
PHE502
3.772
PHE507
3.516
PHE509
4.695
LYS525
3.121
ALA528
4.027
LEU529
4.113
LEU532
4.241
HIS535
3.679
VAL547
3.765
MET548
3.699
PHE551
3.600
ALA552
3.780
LEU575
4.620
VAL576
4.401
SER579
3.853
GLN580
3.805
LEU583
4.967
|
|||||
| PDB ID: 2XSI Human serum albumin complexed with dansyl-L-glutamate and myristic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [17] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKEEQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:70 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:480 or .A:481 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.494
LEU14
4.004
PHE19
4.645
LEU22
3.608
VAL23
4.203
VAL46
4.835
LEU66
3.888
PHE70
4.225
LEU115
4.145
VAL116
4.556
ARG117
2.900
PRO118
4.491
MET123
3.399
PHE134
4.649
LEU135
4.137
TYR138
3.315
LEU139
4.057
ILE142
4.450
TYR150
2.588
PRO152
4.323
LEU154
4.450
PHE157
4.127
ALA158
3.721
TYR161
3.678
PHE165
3.773
LEU182
4.311
ARG186
4.510
ARG209
3.923
ALA210
3.887
LYS212
4.196
ALA213
3.797
VAL216
4.045
PHE228
4.563
SER232
4.527
LEU250
4.882
LEU251
3.742
ALA254
3.721
ARG257
3.081
ALA258
4.408
LEU283
3.557
LEU284
4.133
SER287
2.566
ASP324
3.513
VAL325
4.565
LEU327
3.878
GLY328
4.106
LEU331
4.284
SER342
2.707
VAL344
3.388
LEU345
4.191
LEU347
4.154
ARG348
2.777
ALA350
4.181
LYS351
4.125
GLU354
3.967
PRO384
4.224
LEU387
3.724
ILE388
3.557
ASN391
3.951
TYR401
2.750
PHE403
4.720
ASN405
3.692
ARG410
3.935
TYR411
2.846
LYS414
3.797
VAL415
4.107
VAL418
4.721
LEU423
4.487
VAL426
4.521
LEU430
3.787
VAL433
4.681
GLY434
4.552
MET446
4.394
ALA449
4.156
GLU450
4.177
LEU453
3.720
LEU457
3.908
LEU460
3.864
SER480
3.494
LEU481
4.991
VAL482
4.137
ARG485
2.790
PRO486
4.636
PHE488
3.862
SER489
2.704
LEU491
4.574
PHE502
4.051
PHE507
3.608
PHE509
4.430
LYS525
3.094
ALA528
3.854
LEU529
3.674
LEU532
3.779
HIS535
4.694
VAL547
3.481
MET548
3.799
PHE551
3.450
ALA552
3.805
LEU575
4.666
VAL576
4.539
SER579
3.946
GLN580
3.774
LEU583
4.535
|
|||||
| PDB ID: 3B9M Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [22] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:26 or .A:27 or .A:46 or .A:66 or .A:70 or .A:114 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:232 or .A:235 or .A:236 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:288 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:383 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:402 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:431 or .A:432 or .A:433 or .A:434 or .A:449 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:536 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.730
LEU14
3.893
LEU22
3.502
VAL23
4.028
ALA26
4.738
PHE27
3.688
VAL46
4.939
LEU66
3.818
PHE70
3.405
ARG114
4.703
LEU115
3.069
VAL116
4.947
ARG117
3.380
PRO118
4.946
MET123
3.407
PHE134
4.494
LEU135
4.566
TYR138
3.532
LEU139
3.321
ILE142
3.610
TYR150
2.870
PRO152
3.773
LEU154
3.257
PHE157
4.279
ALA158
3.736
TYR161
3.034
PHE165
3.713
LEU182
4.173
ARG186
3.322
ARG209
2.869
ALA210
3.728
LYS212
4.304
ALA213
3.817
VAL216
4.244
SER232
4.523
VAL235
4.349
THR236
4.871
LEU250
4.798
LEU251
3.698
ALA254
3.576
ARG257
3.161
ALA258
4.262
LEU283
2.918
LEU284
4.087
SER287
2.972
HIS288
4.608
ASP324
3.649
VAL325
4.859
LEU327
4.299
GLY328
3.642
LEU331
4.840
SER342
3.886
VAL344
2.591
LEU345
3.498
LEU347
4.407
ARG348
2.315
ALA350
4.991
LYS351
3.940
GLU354
4.306
GLU383
4.658
PRO384
4.219
LEU387
4.475
ILE388
3.014
ASN391
3.815
TYR401
3.442
LYS402
4.303
PHE403
2.584
ASN405
4.142
LEU407
3.746
ARG410
3.037
TYR411
1.929
LYS414
4.766
VAL415
4.065
VAL418
4.765
LEU423
4.286
VAL426
3.459
LEU430
3.426
GLY431
3.105
LYS432
4.477
VAL433
4.465
GLY434
3.405
ALA449
3.737
LEU453
3.855
LEU457
4.162
LEU460
3.568
VAL482
4.374
ARG485
2.968
PRO486
3.636
PHE488
3.633
SER489
3.503
LEU491
4.203
PHE502
3.914
PHE507
3.878
PHE509
4.333
LYS525
3.580
ALA528
4.359
LEU529
3.907
LEU532
3.817
LYS536
4.886
VAL547
3.426
MET548
4.108
PHE551
3.646
ALA552
4.284
LEU575
4.394
VAL576
4.110
SER579
3.463
GLN580
4.128
|
|||||
| PDB ID: 4LB9 X-ray study of human serum albumin complexed with etoposide | ||||||
| Method | X-ray diffraction | Resolution | 2.70 Å | Mutation | No | [8] |
| PDB Sequence |
AHKSEVAHRF
11 KDLGEENFKA21 LVLIAFAQYL31 QQCPFEDHVK41 LVNEVTEFAK51 TCVADESAEN 61 CDKSLHTLFG71 DKLCTVATLR81 ETYGEMADCC91 AKQEPERNEC101 FLQHKDDNPN 111 LPRLVRPEVD121 VMCTAFHDNE131 ETFLKKYLYE141 IARRHPYFYA151 PELLFFAKRY 161 KAAFTECCQA171 ADKAACLLPK181 LDELRDEGKA191 SSAKQRLKCA201 SLQKFGERAF 211 KAWAVARLSQ221 RFPKAEFAEV231 SKLVTDLTKV241 HTECCHGDLL251 ECADDRADLA 261 KYICENQDSI271 SSKLKECCEK281 PLLEKSHCIA291 EVENDEMPAD301 LPSLAADFVE 311 SKDVCKNYAE321 AKDVFLGMFL331 YEYARRHPDY341 SVVLLLRLAK351 TYETTLEKCC 361 AAADPHECYA371 KVFDEFKPLV381 EEPQNLIKQN391 CELFEQLGEY401 KFQNALLVRY 411 TKKVPQVSTP421 TLVEVSRNLG431 KVGSKCCKHP441 EAKRMPCAED451 YLSVVLNQLC 461 VLHEKTPVSD471 RVTKCCTESL481 VNRRPCFSAL491 EVDETYVPKE501 FNAETFTFHA 511 DICTLSEKER521 QIKKQTALVE531 LVKHKPKATK541 EQLKAVMDDF551 AAFVEKCCKA 561 DDKETCFAEE571 GKKLVAASQA581 ALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:66 or .A:70 or .A:150 or .A:152 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:286 or .A:287 or .A:288 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.609
LEU14
3.891
PHE19
4.968
LEU22
3.684
VAL23
3.638
ALA26
4.112
LEU66
3.678
PHE70
3.600
TYR150
2.916
PRO152
4.083
LEU250
4.215
LEU251
3.762
ALA254
3.170
ARG257
3.200
ALA258
4.156
LEU283
3.579
LEU284
3.616
LYS286
4.925
SER287
2.586
HIS288
4.997
SER342
2.741
VAL344
3.258
LEU345
4.081
ARG348
2.712
PRO384
3.853
LEU387
3.261
ILE388
3.837
ASN391
3.395
TYR401
2.390
PHE403
4.607
ASN405
4.062
ARG410
3.656
TYR411
3.548
VAL415
3.665
VAL418
4.386
LEU423
4.160
VAL426
3.719
LEU430
3.305
VAL433
4.078
GLY434
4.413
MET446
4.003
ALA449
4.140
GLU450
4.262
LEU453
3.832
LEU457
3.963
LEU460
3.561
VAL473
3.628
VAL482
4.938
ARG485
3.400
PRO486
4.525
PHE488
3.528
SER489
2.478
LEU491
3.911
PHE502
3.931
PHE507
3.472
PHE509
4.345
LYS525
3.584
ALA528
3.897
LEU529
3.800
LEU532
3.980
HIS535
4.294
VAL547
3.661
MET548
4.119
PHE551
3.400
ALA552
4.323
LEU575
3.853
VAL576
4.134
SER579
4.185
GLN580
4.646
|
|||||
| PDB ID: 2I30 Human serum albumin complexed with myristate and salicylic acid | ||||||
| Method | X-ray diffraction | Resolution | 2.90 Å | Mutation | No | [24] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:70 or .A:115 or .A:117 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:288 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:431 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:490 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.686
LEU14
3.765
PHE19
4.475
LEU22
4.527
VAL23
4.514
LEU66
3.571
PHE70
3.690
LEU115
4.019
ARG117
2.943
MET123
3.391
PHE134
4.587
LEU135
3.932
TYR138
3.001
LEU139
3.889
ILE142
4.104
TYR150
2.866
PRO152
4.261
LEU154
3.889
PHE157
3.592
ALA158
3.899
TYR161
3.370
PHE165
3.836
LEU182
4.686
ARG186
4.205
LEU250
4.785
LEU251
3.834
ALA254
3.594
ARG257
3.079
ALA258
3.627
LEU283
3.457
LEU284
3.336
SER287
2.677
HIS288
4.579
SER342
2.995
VAL344
3.349
LEU345
4.051
ARG348
2.661
PRO384
3.648
LEU387
3.620
ILE388
3.391
ASN391
3.822
TYR401
3.120
PHE403
3.246
ASN405
3.447
LEU407
4.552
ARG410
4.359
TYR411
3.041
LYS414
4.029
VAL415
3.689
VAL418
3.459
THR422
3.615
LEU423
4.577
VAL426
4.271
LEU430
3.473
GLY431
4.422
VAL433
4.640
GLY434
3.608
MET446
4.156
ALA449
4.224
GLU450
3.972
LEU453
3.622
LEU457
4.054
LEU460
3.421
ARG485
3.071
PRO486
4.690
PHE488
3.716
SER489
2.590
ALA490
4.990
LEU491
4.830
PHE502
3.647
PHE507
3.732
PHE509
4.819
LYS525
3.550
ALA528
3.894
LEU529
4.247
LEU532
3.916
HIS535
4.076
VAL547
4.318
MET548
3.657
PHE551
3.572
ALA552
3.611
LEU575
4.738
VAL576
4.452
SER579
3.690
GLN580
3.826
LEU583
4.885
|
|||||
| PDB ID: 6XV0 lauric acid functionalized hexamolybdoaluminate bound to human serum albumin | ||||||
| Method | X-ray diffraction | Resolution | 3.00 Å | Mutation | No | [25] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 L
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:46 or .A:66 or .A:70 or .A:115 or .A:117 or .A:123 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:185 or .A:189 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:390 or .A:391 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.141
LEU14
3.740
PHE19
4.759
LEU22
3.765
VAL23
4.139
VAL46
4.956
LEU66
3.748
PHE70
4.115
LEU115
4.881
ARG117
2.857
MET123
4.259
LEU135
4.762
TYR138
3.582
LEU139
3.983
ILE142
3.681
TYR150
2.877
PRO152
3.974
LEU154
3.696
PHE157
4.101
ALA158
3.674
TYR161
3.495
PHE165
4.144
LEU182
4.075
LEU185
4.456
GLY189
4.443
ARG209
4.009
ALA210
3.937
LYS212
4.201
ALA213
3.570
VAL216
3.700
PHE228
3.924
SER232
3.657
LEU250
3.774
LEU251
4.133
ALA254
3.611
ARG257
2.314
ALA258
3.938
LEU283
3.300
LEU284
3.757
SER287
2.948
ASP324
3.356
VAL325
4.422
LEU327
3.932
GLY328
4.181
SER342
3.516
VAL344
3.267
LEU345
4.193
LEU347
3.943
ARG348
2.687
ALA350
3.765
LYS351
3.788
GLU354
4.561
PRO384
3.665
LEU387
3.327
ILE388
3.637
GLN390
4.844
ASN391
3.686
TYR401
3.262
PHE403
4.870
ASN405
4.270
ARG410
3.753
TYR411
3.266
LYS414
4.164
VAL415
3.749
VAL418
3.625
LEU423
3.706
VAL426
3.609
LEU430
3.591
VAL433
3.724
GLY434
4.456
MET446
3.668
ALA449
3.666
GLU450
3.948
LEU453
3.667
LEU457
3.602
LEU460
3.625
VAL482
4.700
ARG485
3.052
PRO486
4.961
PHE488
3.567
SER489
3.679
PHE507
3.580
PHE509
4.442
LYS525
3.797
ALA528
3.778
LEU529
3.759
LEU532
3.768
VAL547
3.751
MET548
3.616
PHE551
3.537
ALA552
4.375
LEU575
4.797
VAL576
4.235
SER579
3.621
|
|||||
| PDB ID: 8EY5 Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 3 | ||||||
| Method | X-ray diffraction | Resolution | 3.10 Å | Mutation | No | [26] |
| PDB Sequence |
DAHKSEVAHR
10 FKDLGEENFK20 ALVLIAFAQY30 LQQCPFEDHV40 KLVNEVTEFA50 KTCVADESAE 60 NCDKSLHTLF70 GDKLCTVATL80 RETYGEMADC90 CAKQEPERNE100 CFLQHKDDNP 110 NLPRLVRPEV120 DVMCTAFHDN130 EETFLKKYLY140 EIARRHPYFY150 APELLFFAKR 160 YKAAFTECCQ170 AADKAACLLP180 KLDELRDEGK190 ASSAKQRLKC200 ASLQKFGERA 210 FKAWAVARLS220 QRFPKAEFAE230 VSKLVTDLTK240 VHTECCHGDL250 LECADDRADL 260 AKYICENQDS270 ISSKLKECCE280 KPLLEKSHCI290 AEVENDEMPA300 DLPSLAADFV 310 ESKDVCKNYA320 EAKDVFLGMF330 LYEYARRHPD340 YSVVLLLRLA350 KTYETTLEKC 360 CAAADPHECY370 AKVFDEFKPL380 VEEPQNLIKQ390 NCELFEQLGE400 YKFQNALLVR 410 YTKKVPQVST420 PTLVEVSRNL430 GKVGSKCCKH440 PEAKRMPCAE450 DYLSVVLNQL 460 CVLHEKTPVS470 DRVTKCCTES480 LVNRRPCFSA490 LEVDETYVPK500 EFNAETFTFH 510 ADICTLSEKE520 RQIKKQTALV530 ELVKHKPKAT540 KEQLKAVMDD550 FAAFVEKCCK 560 ADDKETCFAE570 EGKKLVAASQ580 AALG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:108 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:146 or .A:148 or .A:149 or .A:150 or .A:153 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:185 or .A:186 or .A:189 or .A:190 or .A:193 or .A:195 or .A:196 or .A:197 or .A:198 or .A:199 or .A:200 or .A:202 or .A:206 or .A:209 or .A:210 or .A:211 or .A:212 or .A:213 or .A:214 or .A:215 or .A:216 or .A:218 or .A:219 or .A:222 or .A:223 or .A:238 or .A:241 or .A:242 or .A:245 or .A:246 or .A:247 or .A:248 or .A:253 or .A:257 or .A:260 or .A:264 or .A:287 or .A:290 or .A:291 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:402 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:454 or .A:457 or .A:460 or .A:480 or .A:481 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:490 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP108
4.131
LEU115
3.751
VAL116
4.370
ARG117
2.897
PRO118
4.553
MET123
4.159
PHE134
4.026
LEU135
3.724
TYR138
3.560
LEU139
3.772
ILE142
3.451
HIS146
3.325
TYR148
3.319
PHE149
3.730
TYR150
3.601
GLU153
4.821
LEU154
3.861
PHE157
4.257
ALA158
3.666
TYR161
3.281
PHE165
3.662
LEU182
4.067
LEU185
3.772
ARG186
3.469
GLY189
3.447
LYS190
3.181
SER193
3.328
LYS195
3.787
GLN196
3.390
ARG197
2.396
LEU198
4.263
LYS199
2.706
CYS200
3.245
SER202
4.097
PHE206
3.744
ARG209
3.041
ALA210
3.981
PHE211
3.216
LYS212
3.850
ALA213
3.644
TRP214
3.236
ALA215
4.155
VAL216
4.456
ARG218
4.545
LEU219
3.796
ARG222
3.748
PHE223
4.399
LEU238
3.687
VAL241
3.903
HIS242
3.632
CYS245
3.564
CYS246
3.187
HIS247
4.532
GLY248
4.428
CYS253
4.056
ARG257
2.609
LEU260
3.854
ILE264
4.344
SER287
4.252
ILE290
3.533
ALA291
3.735
ASP324
3.521
LEU327
4.229
GLY328
3.785
LEU331
4.514
SER342
2.938
VAL344
2.974
LEU345
3.994
LEU347
3.696
ARG348
2.811
ALA350
4.033
LYS351
3.973
GLU354
4.083
PRO384
3.832
LEU387
3.910
ILE388
3.910
ASN391
3.507
CYS392
4.666
TYR401
3.414
LYS402
4.541
PHE403
4.456
ASN405
3.983
LEU407
4.683
ARG410
3.180
TYR411
3.153
LYS414
3.306
VAL415
4.724
LEU423
4.424
VAL426
3.777
LEU430
3.482
VAL433
3.905
GLY434
3.978
CYS438
4.945
MET446
3.747
ALA449
4.093
GLU450
4.009
LEU453
3.769
SER454
3.276
LEU457
3.952
LEU460
4.053
SER480
3.432
LEU481
3.829
VAL482
3.603
ARG485
2.670
PRO486
4.582
PHE488
3.519
SER489
2.805
ALA490
4.487
LEU491
4.446
PHE502
3.910
PHE507
3.238
PHE509
4.989
LYS525
3.127
ALA528
4.354
LEU529
3.990
LEU532
3.406
HIS535
4.248
VAL547
3.111
MET548
3.223
PHE551
3.214
LEU575
4.477
VAL576
3.849
SER579
4.043
GLN580
3.534
LEU583
4.471
|
|||||
| PDB ID: 1O9X HUMAN SERUM ALBUMIN COMPLEXED WITH TETRADECANOIC ACID (MYRISTIC ACID) AND HEMIN | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [27] |
| PDB Sequence |
KSEVAHRFKD
13 LGEENFKALV23 LIAFAQYLQQ33 CPFEDHVKLV43 NEVTEFAKTC53 VADESAENCD 63 KSLHTLFGDK73 LCTVATLRET83 YGEMADCCAK93 QEPERNECFL103 QHKDDNPNLP 113 RLVRPEVDVM123 CTAFHDNEET133 FLKKYLYEIA143 RRHPYFYAPE153 LLFFAKRYKA 163 AFTECCQAAD173 KAACLLPKLD183 ELRDEGKASS193 AKQRLKCASL203 QKFGERAFKA 213 WAVARLSQRF223 PKAEFAEVSK233 LVTDLTKVHT243 ECCHGDLLEC253 ADDRADLAKY 263 ICENQDSISS273 KLKECCEKPL283 LEKSHCIAEV293 ENDEMPADLP303 SLAADFVESK 313 DVCKNYAEAK323 DVFLGMFLYE333 YARRHPDYSV343 VLLLRLAKTY353 ETTLEKCCAA 363 ADPHECYAKV373 FDEFKPLVEE383 PQNLIKQNCE393 LFEQLGEYKF403 QNALLVRYTK 413 KVPQVSTPTL423 VEVSRNLGKV433 GSKCCKHPEA443 KRMPCAEDYL453 SVVLNQLCVL 463 HEKTPVSDRV473 TKCCTESLVN483 RRPCFSALEV493 DETYVPKEFN503 AETFTFHADI 513 CTLSEKERQI523 KKQTALVELV533 KHKPKATKEQ543 LKAVMDDFAA553 FVEKCCKADD 563 KETCFAEEGK573 KLVAASQAA
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:150 or .A:152 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:219 or .A:222 or .A:223 or .A:238 or .A:241 or .A:242 or .A:245 or .A:251 or .A:254 or .A:255 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:287 or .A:290 or .A:291 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:525 or .A:528 or .A:529 or .A:548 or .A:551 or .A:552; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.478
LEU14
3.807
LEU22
4.081
TYR150
2.434
PRO152
3.921
ARG209
3.018
ALA210
4.446
LYS212
3.328
ALA213
3.899
VAL216
4.149
LEU219
3.433
ARG222
3.649
PHE223
4.972
LEU238
3.645
VAL241
3.630
HIS242
3.423
CYS245
4.538
LEU251
4.939
ALA254
3.084
ASP255
4.846
ARG257
3.221
ALA258
3.761
LEU260
4.280
ILE264
4.374
LEU283
3.738
LEU284
3.938
SER287
2.565
ILE290
3.904
ALA291
3.809
ASP324
3.883
LEU327
3.783
GLY328
4.280
LEU331
4.673
SER342
2.743
VAL344
3.797
LEU345
4.636
LEU347
4.229
ARG348
3.979
LYS351
3.354
GLU354
4.489
PRO384
4.347
LEU387
4.045
ILE388
3.533
ASN391
4.134
TYR401
2.529
ASN405
4.357
ARG410
4.148
TYR411
2.739
VAL415
3.273
VAL418
3.861
LEU423
4.092
VAL426
4.283
LEU430
3.949
VAL433
4.577
MET446
4.428
ALA449
3.867
GLU450
4.306
LEU453
3.673
LEU457
3.803
LEU460
3.657
VAL473
3.713
VAL482
4.954
ARG485
2.500
PRO486
4.773
PHE488
3.626
SER489
2.429
LYS525
2.885
ALA528
4.962
LEU529
4.138
MET548
3.682
PHE551
3.519
ALA552
4.235
|
|||||
| PDB ID: 5IFO X-ray structure of HSA-Myr-KP1019 | ||||||
| Method | X-ray diffraction | Resolution | 3.20 Å | Mutation | No | [28] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:27 or .A:46 or .A:66 or .A:70 or .A:115 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:209 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:286 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:402 or .A:405 or .A:410 or .A:411 or .A:414 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:507 or .A:509 or .A:525 or .A:526 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:575 or .A:576 or .A:579; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
3.682
LEU14
3.731
PHE19
4.276
LEU22
3.659
VAL23
3.816
ALA26
4.371
PHE27
4.952
VAL46
4.267
LEU66
3.652
PHE70
4.010
LEU115
3.767
ARG117
3.657
PRO118
4.890
MET123
3.656
PHE134
4.877
LEU135
3.657
TYR138
3.466
LEU139
3.776
ILE142
4.039
TYR150
2.673
PRO152
4.214
LEU154
3.704
PHE157
4.184
ALA158
3.742
TYR161
3.511
PHE165
3.567
LEU182
4.553
ARG209
3.343
LYS212
4.938
ALA213
3.732
VAL216
4.193
PHE228
4.900
SER232
4.726
LEU250
4.084
LEU251
3.621
ALA254
3.508
ARG257
4.192
ALA258
4.058
LEU283
2.841
LEU284
3.769
LYS286
4.787
SER287
2.934
ASP324
3.541
VAL325
4.841
LEU327
3.952
GLY328
4.047
LEU331
3.873
SER342
3.184
VAL344
3.207
LEU345
4.075
LEU347
4.048
ARG348
2.983
ALA350
4.184
LYS351
3.875
GLU354
3.776
PRO384
3.681
LEU387
3.257
ILE388
3.624
ASN391
3.934
TYR401
3.119
LYS402
3.494
ASN405
3.376
ARG410
4.232
TYR411
2.704
LYS414
4.672
LEU423
4.212
VAL426
3.731
LEU430
3.991
VAL433
4.464
GLY434
4.467
CYS438
4.971
MET446
3.801
ALA449
3.939
GLU450
4.221
LEU453
3.662
LEU457
3.650
LEU460
3.853
ARG485
2.410
PRO486
4.693
PHE488
3.601
SER489
2.642
LEU491
4.593
PHE507
3.499
PHE509
3.851
LYS525
3.283
GLN526
4.739
ALA528
4.142
LEU529
4.250
LEU532
3.721
VAL547
3.908
MET548
3.672
PHE551
4.043
LEU575
4.251
VAL576
4.345
SER579
3.638
|
|||||
| PDB ID: 8EW7 Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 2 | ||||||
| Method | X-ray diffraction | Resolution | 3.30 Å | Mutation | No | [29] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:232 or .A:235 or .A:324 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:403 or .A:405 or .A:407 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG209
3.251
ALA210
4.055
LYS212
3.641
ALA213
3.858
VAL216
4.156
SER232
4.370
VAL235
4.882
ASP324
3.669
LEU327
3.575
GLY328
3.605
LEU331
4.176
SER342
2.346
VAL344
3.368
LEU345
4.105
LEU347
4.548
ARG348
2.906
ALA350
3.865
LYS351
3.197
GLU354
3.986
PRO384
4.002
LEU387
3.536
ILE388
4.105
ASN391
3.746
TYR401
3.309
PHE403
4.278
ASN405
3.787
LEU407
4.318
ARG410
4.039
TYR411
3.262
LYS414
2.844
VAL415
3.613
VAL418
3.977
THR422
4.880
LEU423
3.959
VAL426
3.866
LEU430
3.550
VAL433
3.712
GLY434
3.966
MET446
3.861
ALA449
3.726
GLU450
4.148
LEU453
3.803
LEU457
4.449
LEU460
4.038
VAL473
4.913
VAL482
4.884
ARG485
3.213
PRO486
4.896
PHE488
3.738
SER489
3.273
PHE502
3.742
PHE507
3.434
PHE509
4.565
LYS525
2.793
ALA528
3.333
LEU529
3.642
LEU532
3.663
HIS535
4.502
VAL547
3.714
MET548
3.676
PHE551
3.464
ALA552
3.794
LEU575
4.315
VAL576
3.949
SER579
3.742
GLN580
4.145
LEU583
4.704
|
|||||
| PDB ID: 7Z57 Crystal structure of Human Serum Albumin in complex with surfactant GenX (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy) propanoate) | ||||||
| Method | X-ray diffraction | Resolution | 2.20 Å | Mutation | No | [30] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 L
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:22 or .A:23 or .A:26 or .A:27 or .A:46 or .A:66 or .A:70 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:235 or .A:250 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:287 or .A:324 or .A:325 or .A:327 or .A:328 or .A:347 or .A:350 or .A:351 or .A:354 or .A:401 or .A:405 or .A:482 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:575 or .A:576 or .A:579 or .A:580; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.512
LEU14
4.122
LEU22
4.031
VAL23
4.045
ALA26
4.477
PHE27
4.842
VAL46
4.822
LEU66
3.965
PHE70
3.951
ARG117
3.018
PRO118
4.419
MET123
4.009
PHE134
4.197
LEU135
3.687
TYR138
3.476
LEU139
3.899
ILE142
4.047
TYR150
2.640
PRO152
4.056
LEU154
3.782
PHE157
4.256
ALA158
3.679
TYR161
3.617
PHE165
3.526
LEU182
4.123
ARG186
4.169
ARG209
3.541
ALA210
3.776
LYS212
3.939
ALA213
3.716
VAL216
3.899
PHE228
4.232
SER232
3.831
VAL235
4.259
LEU250
4.222
LEU251
3.681
ALA254
3.506
ARG257
2.979
ALA258
4.000
LEU283
3.805
LEU284
3.743
SER287
2.502
ASP324
3.716
VAL325
4.677
LEU327
3.928
GLY328
4.257
LEU347
4.553
ALA350
4.810
LYS351
4.669
GLU354
4.075
TYR401
3.330
ASN405
4.510
VAL482
4.511
PHE502
3.610
PHE507
3.635
PHE509
4.362
LYS525
3.411
ALA528
3.667
LEU529
3.814
LEU532
3.877
HIS535
3.933
VAL547
3.664
MET548
3.632
PHE551
3.621
LEU575
4.287
VAL576
4.042
SER579
3.847
GLN580
3.780
|
|||||
| PDB ID: 7JWN Crystal structure of Human Serum Albumin in complex with ketoprofen | ||||||
| Method | X-ray diffraction | Resolution | 2.60 Å | Mutation | No | [31] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LGL
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:108 or .A:145 or .A:146 or .A:147 or .A:148 or .A:149 or .A:190 or .A:193 or .A:194 or .A:196 or .A:197 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:405 or .A:430 or .A:433 or .A:434 or .A:437 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:459 or .A:485 or .A:486 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:526 or .A:528 or .A:529 or .A:532 or .A:545 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASP108
3.654
ARG145
4.235
HIS146
3.287
PRO147
4.453
TYR148
3.682
PHE149
3.329
LYS190
3.569
SER193
2.697
ALA194
4.367
GLN196
4.023
ARG197
3.736
SER342
2.623
VAL344
3.347
LEU345
4.022
ARG348
3.128
PRO384
3.984
LEU387
3.818
ILE388
3.883
ASN391
3.828
CYS392
3.646
TYR401
3.495
ASN405
4.211
LEU430
4.766
VAL433
4.044
GLY434
4.024
CYS437
4.501
CYS438
3.846
MET446
4.063
ALA449
4.250
GLU450
4.177
LEU453
3.650
GLN459
3.866
ARG485
2.663
PRO486
4.525
SER489
4.903
PHE502
4.612
PHE507
3.989
PHE509
4.222
LYS525
3.558
GLN526
4.928
ALA528
3.872
LEU529
4.136
LEU532
4.301
LYS545
3.924
VAL547
3.764
MET548
3.955
PHE551
3.594
ALA552
4.232
LEU575
4.758
VAL576
4.217
SER579
3.907
|
|||||
| PDB ID: 3SQJ Recombinant human serum albumin from transgenic plant | ||||||
| Method | X-ray diffraction | Resolution | 2.05 Å | Mutation | No | [32] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:7 or .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:30 or .A:45 or .A:46 or .A:49 or .A:66 or .A:67 or .A:69 or .A:70 or .A:73 or .A:99 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:153 or .A:154 or .A:157 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:196 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:219 or .A:222 or .A:223 or .A:228 or .A:232 or .A:235 or .A:238 or .A:241 or .A:242 or .A:245 or .A:249 or .A:250 or .A:251 or .A:253 or .A:254 or .A:257 or .A:258 or .A:260 or .A:264 or .A:283 or .A:284 or .A:287 or .A:290 or .A:291 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:410 or .A:411 or .A:414 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL7
4.412
ARG10
3.698
LEU14
4.003
PHE19
3.796
LEU22
4.137
VAL23
4.090
ALA26
4.118
TYR30
3.637
GLU45
3.652
VAL46
3.395
PHE49
3.578
LEU66
4.234
HIS67
3.860
LEU69
3.265
PHE70
3.451
LYS73
3.384
ASN99
3.931
LEU115
4.693
VAL116
4.799
ARG117
2.757
PRO118
4.975
MET123
4.568
LEU135
4.198
TYR138
3.565
LEU139
3.792
ILE142
3.769
TYR150
2.678
PRO152
3.673
GLU153
4.574
LEU154
4.245
PHE157
4.360
ALA158
3.578
TYR161
3.599
PHE165
3.848
LEU182
4.133
ARG186
3.809
GLN196
3.174
ARG209
4.027
ALA210
3.310
LYS212
4.257
ALA213
3.890
VAL216
3.669
LEU219
3.536
ARG222
4.633
PHE223
4.462
PHE228
4.058
SER232
4.233
VAL235
4.682
LEU238
3.933
VAL241
3.699
HIS242
3.252
CYS245
3.621
ASP249
3.714
LEU250
3.258
LEU251
3.364
CYS253
4.095
ALA254
3.364
ARG257
2.731
ALA258
3.572
LEU260
3.958
ILE264
3.988
LEU283
3.551
LEU284
3.899
SER287
2.579
ILE290
3.703
ALA291
4.077
ASP324
3.748
VAL325
4.725
LEU327
3.943
GLY328
3.968
LEU331
4.486
SER342
2.887
VAL344
3.544
LEU345
4.402
LEU347
4.207
ARG348
2.887
ALA350
3.700
LYS351
3.566
GLU354
3.649
PRO384
3.897
LEU387
3.768
ILE388
3.923
ASN391
3.978
CYS392
4.720
TYR401
2.403
PHE403
4.115
ASN405
3.740
ARG410
3.874
TYR411
3.217
LYS414
4.903
VAL415
3.521
VAL418
4.314
LEU423
4.390
VAL426
4.628
LEU430
4.181
VAL433
3.938
GLY434
4.282
CYS438
4.720
MET446
3.844
ALA449
3.903
GLU450
3.924
LEU453
3.883
LEU457
3.561
LEU460
3.835
VAL473
4.876
VAL482
3.792
ARG485
2.856
PRO486
4.459
PHE488
3.598
SER489
2.675
LEU491
4.621
PHE502
4.060
PHE507
3.726
PHE509
4.822
LYS525
3.146
ALA528
3.553
LEU529
4.029
LEU532
3.859
HIS535
3.510
VAL547
3.657
MET548
3.749
PHE551
3.634
ALA552
4.866
LEU575
4.414
VAL576
3.865
SER579
3.633
GLN580
3.814
LEU583
4.562
|
|||||
| PDB ID: 3CX9 Crystal Structure of Human serum albumin complexed with Myristic acid and lysophosphatidylethanolamine | ||||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [33] |
| PDB Sequence |
HKSEVAHRFK
12 DLGEENFKAL22 VLIAFAQYLQ32 QCPFEDHVKL42 VNEVTEFAKT52 CVADESAENC 62 DKSLHTLFGD72 KLCTVATLRE82 TYGEMADCCA92 KQEPERNECF102 LQHKDDNPNL 112 PRLVRPEVDV122 MCTAFHDNEE132 TFLKKYLYEI142 ARRHPYFYAP152 ELLFFAKRYK 162 AAFTECCQAA172 DKAACLLPKL182 DELRDEGKAS192 SAKQRLKCAS202 LQKFGERAFK 212 AWAVARLSQR222 FPKAEFAEVS232 KLVTDLTKVH242 TECCHGDLLE252 CADDRADLAK 262 YICENQDSIS272 SKLKECCEKP282 LLEKSHCIAE292 VENDEMPADL302 PSLAADFVES 312 KDVCKNYAEA322 KDVFLGMFLY332 EYARRHPDYS342 VVLLLRLAKT352 YETTLEKCCA 362 AADPHECYAK372 VFDEFKPLVE382 EPQNLIKQNC392 ELFEQLGEYK402 FQNALLVRYT 412 KKVPQVSTPT422 LVEVSRNLGK432 VGSKCCKHPE442 AKRMPCAEDY452 LSVVLNQLCV 462 LHEKTPVSDR472 VTKCCTESLV482 NRRPCFSALE492 VDETYVPKEF502 NAETFTFHAD 512 ICTLSEKERQ522 IKKQTALVEL532 VKHKPKATKE542 QLKAVMDDFA552 AFVEKCCKAD 562 DKETCFAEEG572 KKLVAASQAA582 LG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:26 or .A:66 or .A:150 or .A:152 or .A:209 or .A:210 or .A:212 or .A:213 or .A:216 or .A:228 or .A:232 or .A:235 or .A:250 or .A:251 or .A:254 or .A:283 or .A:284 or .A:324 or .A:325 or .A:327 or .A:328 or .A:331 or .A:342 or .A:344 or .A:345 or .A:347 or .A:348 or .A:350 or .A:351 or .A:354 or .A:384 or .A:387 or .A:388 or .A:391 or .A:392 or .A:401 or .A:403 or .A:405 or .A:407 or .A:411 or .A:415 or .A:418 or .A:422 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:438 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:473 or .A:480 or .A:482 or .A:485 or .A:486 or .A:488 or .A:489 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:547 or .A:548 or .A:551 or .A:552 or .A:575 or .A:576 or .A:579 or .A:580; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.494
LEU14
3.533
PHE19
4.816
LEU22
3.806
VAL23
4.083
ALA26
4.424
LEU66
3.130
TYR150
4.699
PRO152
4.167
ARG209
3.828
ALA210
3.590
LYS212
3.838
ALA213
3.880
VAL216
3.960
PHE228
4.150
SER232
4.041
VAL235
4.927
LEU250
4.267
LEU251
4.044
ALA254
3.563
LEU283
4.054
LEU284
4.222
ASP324
3.612
VAL325
4.910
LEU327
4.249
GLY328
3.715
LEU331
4.275
SER342
3.209
VAL344
3.231
LEU345
4.412
LEU347
3.917
ARG348
2.224
ALA350
4.358
LYS351
3.954
GLU354
4.133
PRO384
4.084
LEU387
3.804
ILE388
4.130
ASN391
3.716
CYS392
4.721
TYR401
3.080
PHE403
4.633
ASN405
3.816
LEU407
4.993
TYR411
3.428
VAL415
3.379
VAL418
3.096
THR422
4.263
LEU423
3.273
VAL426
4.089
LEU430
3.722
VAL433
3.694
GLY434
3.650
CYS438
4.911
MET446
4.297
ALA449
3.933
GLU450
3.433
LEU453
3.535
LEU457
3.591
LEU460
4.085
VAL473
4.682
SER480
4.480
VAL482
3.502
ARG485
2.907
PRO486
4.680
PHE488
3.967
SER489
4.238
PHE502
4.359
PHE507
3.366
PHE509
4.662
LYS525
2.922
ALA528
3.616
LEU529
3.994
LEU532
3.592
VAL547
4.255
MET548
3.642
PHE551
3.480
ALA552
4.962
LEU575
3.684
VAL576
4.340
SER579
3.725
GLN580
4.201
|
|||||
| PDB ID: 1BKE HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID | ||||||
| Method | X-ray diffraction | Resolution | 3.15 Å | Mutation | No | [19] |
| PDB Sequence |
KSEVAHRFKD
13 LGEENFKALV23 LIAFAQYLQQ33 CPFEDHVKLV43 NEVTEFAKTC53 VADESAENCD 63 KSLHTLFGDK73 LCTVATLRET83 YGEMADCCAK93 QEPERNECFL103 QHKDDNPNLP 113 RLVRPEVDVM123 CTAFHDNEET133 FLKKYLYEIA143 RRHPYFYAPE153 LLFFAKRYKA 163 AFTECCQAAD173 KAACLLPKLD183 ELRDEGKASS193 AKQRLKCASL203 QKFGERAFKA 213 WAVARLSQRF223 PKAEFAEVSK233 LVTDLTKVHT243 ECCHGDLLEC253 ADDRADLAKY 263 ICENQDSISS273 KLKECCEKPL283 LEKSHCIAEV293 ENDEMPADLP303 SLAADFVESK 313 DVCKNYAEAK323 DVFLGMFLYE333 YARRHPDYSV343 VLLLRLAKTY353 ETTLEKCCAA 363 ADPHECYAKV373 FDEFKPLVEE383 PQNLIKQNCE393 LFEQLGEYKF403 QNALLVRYTK 413 KVPQVSTPTL423 VEVSRNLGKV433 GSKCCKHPEA443 KRMPCAEDYL453 SVVLNQLCVL 463 HEKTPVSDRV473 TKCCTESLVN483 RRPCFSALEV493 DETYVPKEFN503 AETFTFHADI 513 CTLSEKERQI523 KKQTALVELV533 KHKPKATKEQ543 LKAVMDDFAA553 FVEKCCKADD 563 KETCFAEEGK573 KLVAASQAAL583 G
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MYR or .MYR2 or .MYR3 or :3MYR;style chemicals stick;color identity;select .A:10 or .A:14 or .A:19 or .A:22 or .A:23 or .A:66 or .A:115 or .A:116 or .A:117 or .A:118 or .A:123 or .A:134 or .A:135 or .A:138 or .A:139 or .A:142 or .A:150 or .A:152 or .A:158 or .A:161 or .A:165 or .A:182 or .A:186 or .A:251 or .A:254 or .A:257 or .A:258 or .A:283 or .A:284 or .A:285 or .A:286 or .A:287 or .A:288 or .A:342 or .A:344 or .A:345 or .A:348 or .A:384 or .A:387 or .A:388 or .A:391 or .A:401 or .A:405 or .A:410 or .A:411 or .A:415 or .A:418 or .A:423 or .A:426 or .A:430 or .A:433 or .A:434 or .A:446 or .A:449 or .A:450 or .A:453 or .A:457 or .A:460 or .A:485 or .A:486 or .A:488 or .A:489 or .A:491 or .A:502 or .A:507 or .A:509 or .A:525 or .A:528 or .A:529 or .A:532 or .A:535 or .A:547 or .A:548 or .A:551 or .A:552 or .A:576 or .A:579 or .A:580 or .A:583; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ARG10
4.085
LEU14
4.054
PHE19
4.610
LEU22
4.386
VAL23
4.427
LEU66
3.904
LEU115
4.973
VAL116
4.646
ARG117
3.185
PRO118
4.922
MET123
3.351
PHE134
4.840
LEU135
3.985
TYR138
3.163
LEU139
3.938
ILE142
4.097
TYR150
2.814
PRO152
3.977
ALA158
4.156
TYR161
3.589
PHE165
3.898
LEU182
3.812
ARG186
4.014
LEU251
3.963
ALA254
3.602
ARG257
3.276
ALA258
4.310
LEU283
3.313
LEU284
3.901
GLU285
4.383
LYS286
4.808
SER287
2.325
HIS288
4.945
SER342
2.748
VAL344
3.438
LEU345
4.224
ARG348
2.456
PRO384
3.784
LEU387
3.564
ILE388
3.325
ASN391
3.915
TYR401
3.157
ASN405
3.952
ARG410
2.762
TYR411
2.590
VAL415
3.526
VAL418
4.678
LEU423
4.134
VAL426
3.982
LEU430
3.649
VAL433
4.247
GLY434
4.183
MET446
4.241
ALA449
4.200
GLU450
4.434
LEU453
3.614
LEU457
4.030
LEU460
3.653
ARG485
3.184
PRO486
4.945
PHE488
3.561
SER489
2.676
LEU491
4.932
PHE502
3.477
PHE507
3.076
PHE509
4.825
LYS525
2.811
ALA528
4.066
LEU529
4.186
LEU532
4.174
HIS535
4.429
VAL547
4.005
MET548
3.604
PHE551
3.700
ALA552
3.947
VAL576
4.284
SER579
3.698
GLN580
4.205
LEU583
4.484
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of Human Serum Albumin in complex with Aristolochic Acid at 1.9 A resolution | ||||
| REF 2 | Structural and mechanistic insights for the binding of aristolochic acids and their active metabolites to human serum albumin | ||||
| REF 3 | Structural and mechanistic insights for the binding of aristolochic acids and their active metabolites to | ||||
| REF 4 | Structural and mechanistic insights for the binding of aristolochic acids and their active metabolites to human serum albumin | ||||
| REF 5 | Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid. Int J Biol Macromol. 2022 Sep 1;216:172-178. | ||||
| REF 6 | Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis. Adv Sci (Weinh). 2020 Nov 9;7(24):2002997. | ||||
| REF 7 | The atomic structure of human methemalbumin at 1.9 A. Biochem Biophys Res Commun. 2002 Mar 8;291(4):813-9. | ||||
| REF 8 | Structural studies of several clinically important oncology drugs in complex with human serum albumin. Biochim Biophys Acta. 2013 Dec;1830(12):5356-74. | ||||
| REF 9 | Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146. J Am Chem Soc. 2010 Jan 20;132(2):824-32. | ||||
| REF 10 | Structural basis of the drug-binding specificity of human serum albumin | ||||
| REF 11 | Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin. Mol Pharmacol. 2020 Dec;98(6):648-657. | ||||
| REF 12 | Structural Analysis of Human Serum Albumin in Complex with the Fibrate Drug Gemfibrozil. Int J Mol Sci. 2022 Feb 4;23(3):1769. | ||||
| REF 13 | Structural basis of the drug-binding specificity of human serum albumin. J Mol Biol. 2005 Oct 14;353(1):38-52. | ||||
| REF 14 | Effects of Myristate on the Induced Circular Dichroism Spectra of Aripiprazole Bound to Human Serum Albumin: A Structural-Chemical Investigation. doi:10.1021/acsomega.1c06220. | ||||
| REF 15 | Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J Biol Chem. 2000 Dec 8;275(49):38731-8. | ||||
| REF 16 | Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6440-5. | ||||
| REF 17 | Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin. J Struct Biol. 2011 Apr;174(1):84-91. | ||||
| REF 18 | Human Serum Albumin with Cobalt (II) and Myristic Acid | ||||
| REF 19 | Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat Struct Biol. 1998 Sep;5(9):827-35. | ||||
| REF 20 | Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin. J Mol Biol. 2000 Nov 10;303(5):721-32. | ||||
| REF 21 | Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I. J Biol Chem. 2001 Jun 22;276(25):22804-9. | ||||
| REF 22 | A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography. J Struct Biol. 2008 Apr;162(1):40-9. | ||||
| REF 23 | A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin. Protein Sci. 2011 Dec;20(12):2095-101. | ||||
| REF 24 | Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin. J Struct Biol. 2007 Feb;157(2):348-55. | ||||
| REF 25 | Binding of a Fatty Acid-Functionalized Anderson-Type Polyoxometalate to Human Serum Albumin. Inorg Chem. 2020 Apr 20;59(8):5243-5246. | ||||
| REF 26 | Human Serum Albumin with Cobalt (II) and Myristic Acid | ||||
| REF 27 | Crystal structural analysis of human serum albumin complexed with hemin and fatty acid. BMC Struct Biol. 2003 Jul 7;3:6. | ||||
| REF 28 | X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism. J Med Chem. 2016 Jun 23;59(12):5894-903. | ||||
| REF 29 | Human Serum Albumin with Cobalt (II) and Myristic Acid | ||||
| REF 30 | Investigation of the Interaction between Human Serum Albumin and Branched Short-Chain Perfluoroalkyl Compounds. Chem Res Toxicol. 2022 Nov 21;35(11):2049-2058. | ||||
| REF 31 | Crystal structure of Human Serum Albumin in complex with ketoprofen | ||||
| REF 32 | Large-scale production of functional human serum albumin from transgenic rice seeds. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19078-83. | ||||
| REF 33 | Structural basis of transport of lysophospholipids by human serum albumin. Biochem J. 2009 Sep 14;423(1):23-30. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.