Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T65200 Target Info
Target Name Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
Synonyms HSD11B1; 11beta-HSD1A; 11HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-HSD1; 11-DH; 11 beta-hydroxysteroid dehydrogenase type 1
Target Type Clinical trial Target
Gene Name HSD11B1
Biochemical Class Short-chain dehydrogenases reductase
UniProt ID
DHI1_HUMAN
Ligand General Information  Top
Ligand Name NADPH Ligand Info
Canonical SMILES C1C=CN(C=C1C(=O)N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)(O)O)O)O)O
InChI 1S/C21H30N7O17P3/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
InChIKey ACFIXJIJDZMPPO-NNYOXOHSSA-N
PubChem Compound ID 5884
Drug Binding Sites of Target  Top
PDB ID: 1XU9      Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1
Method X-ray diffraction Resolution 1.55 Å Mutation Yes [1]
PDB Sequence
QPLNEEFRPE
30
MLQGKKVIVT
40
GASKGIGREM
50
AYHLAKMGAH
60
VVVTARSKET
70

LQKVVSHCLE
80
LGAASAHYIA
90
GTMEDMTFAE
100
QFVAQAGKLM
110
GGLDMLILNH
120

ITNTSLNLFH
130
DDIHHVRKSM
140
EVNFLSYVVL
150
TVAALPMLKQ
160
SNGSIVVVSS
170

LAGKVAYPMV
180
AAYSASKFAL
190
DGFFSSIRKE
200
YSVSRVNVSI
210
TLCVLGLIDT
220

ETAMKAVSGI
230
VHMQAAPKEE
240
CALEIIKGGA
250
LRQEEVYYDS
260
SLWTTLLIRN
270

PSRKILEFLY
280
STSYNMDRF
Residue
Distance (Å)
GLY41
3.195
ALA42
3.598
SER43
2.728
LYS44
3.637
GLY45
3.325
ILE46
2.859
GLY47
4.478
THR64
4.905
ALA65
3.533
ARG66
2.836
SER67
3.286
THR70
4.541
GLY91
3.817
THR92
3.120
MET93
2.923
GLU94
4.133
ASN119
2.816
HIS120
3.731
Residue
Distance (Å)
ILE121
3.009
THR122
4.115
ASN123
4.170
VAL142
4.180
TYR147
4.145
VAL168
3.403
SER169
3.485
SER170
3.168
LEU171
4.869
TYR183
2.544
LYS187
2.914
LEU215
3.371
GLY216
3.287
LEU217
3.612
ILE218
2.939
THR220
2.818
THR222
2.667
ALA223
3.643
PDB ID: 1XU7      Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1
Method X-ray diffraction Resolution 1.80 Å Mutation Yes [1]
PDB Sequence
QPLNEEFRPE
30
MLQGKKVIVT
40
GASKGIGREM
50
AYHLAKMGAH
60
VVVTARSKET
70

LQKVVSHCLE
80
LGAASAHYIA
90
GTMEDMTFAE
100
QFVAQAGKLM
110
GGLDMLILNH
120

ITNTSLNLFH
130
DDIHHVRKSM
140
EVNFLSYVVL
150
TVAALPMLKQ
160
SNGSIVVVSS
170

LAGKVAYPMV
180
AAYSASKFAL
190
DGFFSSIRKE
200
YSVSRVNVSI
210
TLCVLGLIDT
220

ETAMKAVSGI
230
VHMQAAPKEE
240
CALEIIKGGA
250
LRQEEVYYDS
260
SLWTTLLIRN
270

PSRKILEFLY
280
STS
Residue
Distance (Å)
GLY41
3.292
ALA42
3.750
SER43
2.643
LYS44
3.569
GLY45
3.343
ILE46
2.876
GLY47
4.511
ALA65
3.412
ARG66
2.797
SER67
3.252
THR70
4.484
GLY91
3.780
THR92
3.034
MET93
2.816
GLU94
3.884
ASN119
2.707
HIS120
3.649
ILE121
2.978
Residue
Distance (Å)
THR122
4.059
ASN123
3.998
VAL142
4.083
TYR147
4.056
VAL168
3.327
SER169
3.459
SER170
3.185
LEU171
4.847
TYR183
2.577
LYS187
2.812
LEU215
3.307
GLY216
3.174
LEU217
3.666
ILE218
2.862
THR220
2.694
THR222
2.599
ALA223
3.447
PDB ID: 4K1L      4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 beta-HSD1 inhibitors for the treatment of diabetes
Method X-ray diffraction Resolution 1.96 Å Mutation Yes [2]
PDB Sequence
QPLNEEFRPE
30
MLQGKKVIVT
40
GASKGIGREM
50
AYHLAKMGAH
60
VVVTARSKET
70

LQKVVSHCLE
80
LGAASAHYIA
90
GTMEDMTFAE
100
QFVAQAGKLM
110
GGLDMLILNH
120

ITNTSLNLFH
130
DDIHHVRKSM
140
EVNFLSYVVL
150
TVAALPMLKQ
160
SNGSIVVVSS
170

LAGKVAYPMV
180
AAYSASKFAL
190
DGFFSSIRKE
200
YSVSRVNVSI
210
TLCVLGLIDT
220

ETAMKAVSGI
230
VHMQAAPKEE
240
CALEIIKGGA
250
LRQEEVYYDS
260
SLWTTLLIRN
270

PSRKILEFLY
280
STS
Residue
Distance (Å)
GLY41
3.144
ALA42
3.723
SER43
2.832
LYS44
3.428
GLY45
3.474
ILE46
2.970
GLY47
4.542
ALA65
3.699
ARG66
2.806
SER67
2.587
THR70
4.782
GLY91
3.877
THR92
3.036
MET93
2.762
GLU94
3.949
ASN119
2.698
HIS120
3.623
Residue
Distance (Å)
ILE121
3.072
THR122
4.164
ASN123
4.436
VAL142
4.154
TYR147
3.984
VAL168
3.407
SER169
3.261
SER170
3.202
TYR183
2.511
LYS187
2.945
LEU215
3.234
GLY216
3.066
LEU217
3.704
ILE218
2.837
THR220
2.688
THR222
2.916
ALA223
3.368
PDB ID: 4HX5      Crystal structure of 11 beta-HSD1 in complex with SAR184841
Method X-ray diffraction Resolution 2.19 Å Mutation Yes [3]
PDB Sequence
EEFRPEMLQG
34
KKVIVTGASK
44
GIGREMAYHL
54
AKMGAHVVVT
64
ARSKETLQKV
74

VSHCLELGAA
84
SAHYIAGTME
94
DMTFAEQFVA
104
QAGKLMGGLD
114
MLILNHITNT
124

SLNLFHDDIH
134
HVRKSMEVNF
144
LSYVVLTVAA
154
LPMLKQSNGS
164
IVVVSSLAGK
174

VAYPMVAAYS
184
ASKFALDGFF
194
SSIRKEYSVS
204
RVNVSITLCV
214
LGLIDTETAM
224

KAVSGIVHMQ
234
AAPKEECALE
244
IIKGGALRQE
254
EVYYDSSLWT
264
TLLIRNPSRK
274

ILEFLYSTSY
284
N
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDP or .NDP2 or .NDP3 or :3NDP;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:44 or .A:45 or .A:46 or .A:47 or .A:65 or .A:66 or .A:67 or .A:70 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:120 or .A:121 or .A:122 or .A:123 or .A:142 or .A:147 or .A:168 or .A:169 or .A:170 or .A:171 or .A:183 or .A:187 or .A:215 or .A:216 or .A:217 or .A:218 or .A:220 or .A:222 or .A:223; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY41
3.174
ALA42
3.713
SER43
2.701
LYS44
3.671
GLY45
3.351
ILE46
2.903
GLY47
4.447
ALA65
3.500
ARG66
2.761
SER67
2.616
THR70
4.663
GLY91
3.842
THR92
3.128
MET93
2.886
GLU94
4.094
ASN119
2.702
HIS120
3.753
ILE121
3.020
Residue
Distance (Å)
THR122
4.121
ASN123
4.272
VAL142
4.173
TYR147
4.018
VAL168
3.414
SER169
3.285
SER170
3.638
LEU171
4.988
TYR183
2.620
LYS187
2.859
LEU215
3.247
GLY216
3.335
LEU217
3.490
ILE218
2.749
THR220
2.666
THR222
2.996
ALA223
3.375
PDB ID: 3QQP      Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor
Method X-ray diffraction Resolution 2.72 Å Mutation Yes [4]
PDB Sequence
QQPLNEEFRP
29
EMLQGKKVIV
39
TGASKGIGRE
49
MAYHLAKMGA
59
HVVVTARSKE
69

TLQKVVSHCL
79
ELGAASAHYI
89
AGTMEDMTFA
99
EQFVAQAGKL
109
MGGLDMLILN
119

HITNTSLNLF
129
HDDIHHVRKS
139
MEVNFLSYVV
149
LTVAALPMLK
159
QSNGSIVVVS
169

SLAGKVAYPM
179
VAAYSASKFA
189
LDGFFSSIRK
199
EYSVSRVNVS
209
ITLCVLGLID
219

TETAMKAVSG
229
IVHMQAAPKE
239
ECALEIIKGG
249
ALRQEEVYYD
259
SSLWTTLLIR
269

NPSRKILEFL
279
YSTSYNMDRF
289
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDP or .NDP2 or .NDP3 or :3NDP;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:44 or .A:45 or .A:46 or .A:47 or .A:64 or .A:65 or .A:66 or .A:67 or .A:70 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:120 or .A:121 or .A:122 or .A:123 or .A:142 or .A:147 or .A:168 or .A:169 or .A:170 or .A:183 or .A:187 or .A:215 or .A:216 or .A:217 or .A:218 or .A:220 or .A:222 or .A:223; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY41
3.189
ALA42
3.604
SER43
2.893
LYS44
3.376
GLY45
3.221
ILE46
2.689
GLY47
4.469
THR64
4.932
ALA65
3.507
ARG66
2.709
SER67
3.179
THR70
4.514
GLY91
4.074
THR92
3.186
MET93
2.867
GLU94
4.140
ASN119
2.650
HIS120
3.732
Residue
Distance (Å)
ILE121
3.057
THR122
4.080
ASN123
4.268
VAL142
3.967
TYR147
3.880
VAL168
3.290
SER169
3.138
SER170
3.598
TYR183
2.510
LYS187
2.866
LEU215
3.198
GLY216
3.182
LEU217
3.656
ILE218
2.968
THR220
2.669
THR222
2.724
ALA223
3.221
PDB ID: 2RBE      The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors
Method X-ray diffraction Resolution 1.90 Å Mutation Yes [5]
PDB Sequence
EEFRPEMLQG
34
KKVIVTGASK
44
GIGREMAYHL
54
AKMGAHVVVT
64
ARSKETLQKV
74

VSHCLELGAA
84
SAHYIAGTME
94
DMTFAEQFVA
104
QAGKLMGGLD
114
MLILNHITNT
124

SLNLFHDDIH
134
HVRKSMEVNF
144
LSYVVLTVAA
154
LPMLKQSNGS
164
IVVVSSLAGK
174

VAYPMVAAYS
184
ASKFALDGFF
194
SSIRKEYSVS
204
RVNVSITLCV
214
LGLIDTETAM
224

KAVSGIVHMQ
234
AAPKEECALE
244
IIKGGALRQE
254
EVYYDSSLWT
264
TLLIRNPSRK
274

ILEFLYSTY
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDP or .NDP2 or .NDP3 or :3NDP;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:44 or .A:45 or .A:46 or .A:47 or .A:65 or .A:66 or .A:67 or .A:70 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:120 or .A:121 or .A:122 or .A:123 or .A:142 or .A:147 or .A:168 or .A:169 or .A:170 or .A:183 or .A:187 or .A:215 or .A:216 or .A:217 or .A:218 or .A:220 or .A:222 or .A:223; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY41
3.210
ALA42
3.705
SER43
2.658
LYS44
3.549
GLY45
3.390
ILE46
2.876
GLY47
4.453
ALA65
3.528
ARG66
2.755
SER67
2.642
THR70
4.769
GLY91
3.775
THR92
3.186
MET93
3.562
GLU94
3.718
ASN119
2.660
HIS120
3.975
Residue
Distance (Å)
ILE121
3.166
THR122
4.126
ASN123
4.046
VAL142
4.294
TYR147
3.856
VAL168
3.453
SER169
3.331
SER170
3.699
TYR183
2.633
LYS187
2.952
LEU215
3.418
GLY216
3.062
LEU217
3.534
ILE218
2.678
THR220
3.150
THR222
2.997
ALA223
3.378
PDB ID: 3BYZ      2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
Method X-ray diffraction Resolution 2.69 Å Mutation Yes [6]
PDB Sequence
EEFRPEMLQG
34
KKVIVTGASK
44
GIGREMAYHL
54
AKMGAHVVVT
64
ARSKETLQKV
74

VSHCLELGAA
84
SAHYIAGTME
94
DMTFAEQFVA
104
QAGKLMGGLD
114
MLILNHITNT
124

SLNLFHDDIH
134
HVRKSMEVNF
144
LSYVVLTVAA
154
LPMLKQSNGS
164
IVVVSSLAGK
174

VAYPMVAAYS
184
ASKFALDGFF
194
SSIRKEYSVS
204
RVNVSITLCV
214
LGLIDTETAM
224

KAVSGIVHMQ
234
AAPKEECALE
244
IIKGGALRQE
254
EVYYDSSLWT
264
TLLIRNPSRK
274

ILEFLYST
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDP or .NDP2 or .NDP3 or :3NDP;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:44 or .A:45 or .A:46 or .A:47 or .A:65 or .A:66 or .A:67 or .A:70 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:120 or .A:121 or .A:122 or .A:123 or .A:142 or .A:147 or .A:168 or .A:169 or .A:170 or .A:183 or .A:187 or .A:215 or .A:216 or .A:217 or .A:218 or .A:220 or .A:222 or .A:223; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY41
3.098
ALA42
3.585
SER43
2.968
LYS44
3.063
GLY45
3.341
ILE46
2.878
GLY47
4.292
ALA65
3.380
ARG66
2.409
SER67
2.481
THR70
4.549
GLY91
3.966
THR92
3.187
MET93
3.024
GLU94
4.161
ASN119
2.881
HIS120
3.962
Residue
Distance (Å)
ILE121
3.254
THR122
4.286
ASN123
4.700
VAL142
4.103
TYR147
4.024
VAL168
3.515
SER169
3.153
SER170
3.106
TYR183
2.745
LYS187
2.759
LEU215
3.320
GLY216
3.203
LEU217
3.601
ILE218
2.638
THR220
2.733
THR222
2.599
ALA223
3.342
PDB ID: 3EY4      Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
Method X-ray diffraction Resolution 3.00 Å Mutation Yes [7]
PDB Sequence
EEFRPEMLQG
34
KKVIVTGASK
44
GIGREMAYHL
54
AKMGAHVVVT
64
ARSKETLQKV
74

VSHCLELGAA
84
SAHYIAGTME
94
DMTFAEQFVA
104
QAGKLMGGLD
114
MLILNHITNT
124

SLNLFHDDIH
134
HVRKSMEVNF
144
LSYVVLTVAA
154
LPMLKQSNGS
164
IVVVSSLAGK
174

VAYPMVAAYS
184
ASKFALDGFF
194
SSIRKEYSVS
204
RVNVSITLCV
214
LGLIDTETAM
224

KAVSGIVHMQ
234
AAPKEECALE
244
IIKGGALRQE
254
EVYYDSSLWT
264
TLLIRNPSRK
274

ILEFLYSTS
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDP or .NDP2 or .NDP3 or :3NDP;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:44 or .A:45 or .A:46 or .A:47 or .A:64 or .A:65 or .A:66 or .A:67 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:120 or .A:121 or .A:122 or .A:123 or .A:142 or .A:147 or .A:168 or .A:169 or .A:170 or .A:171 or .A:183 or .A:187 or .A:215 or .A:216 or .A:217 or .A:218 or .A:220 or .A:222 or .A:223; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY41
3.213
ALA42
3.855
SER43
2.822
LYS44
2.860
GLY45
3.520
ILE46
2.899
GLY47
3.736
THR64
4.688
ALA65
3.542
ARG66
2.686
SER67
2.585
GLY91
3.624
THR92
3.078
MET93
3.034
GLU94
4.527
ASN119
3.135
HIS120
3.812
ILE121
3.171
Residue
Distance (Å)
THR122
4.286
ASN123
4.194
VAL142
4.696
TYR147
4.050
VAL168
3.168
SER169
3.602
SER170
3.020
LEU171
4.913
TYR183
2.472
LYS187
2.514
LEU215
3.643
GLY216
3.280
LEU217
3.467
ILE218
2.958
THR220
2.836
THR222
2.616
ALA223
3.492
PDB ID: 4P38      Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329
Method X-ray diffraction Resolution 2.80 Å Mutation No [8]
PDB Sequence
EFRPEMLQGK
35
KVIVTGASKG
45
IGREMAYHLA
55
KMGAHVVVTA
65
RSKETLQKVV
75

SHCLELGAAS
85
AHYIAGTMED
95
MTFAEQFVAQ
105
AGKLMGGLDM
115
LILNHITNTS
125

LNLFHDDIHH
135
VRKSMEVNFL
145
SYVVLTVAAL
155
PMLKQSNGSI
165
VVVSSLAGKV
175

AYPLVAAYSA
185
SKFALDGFFS
195
SIRKEYSVSR
205
VNVSITLCVL
215
GLIDTETAMK
225

AVSGIVHMQA
235
APKEECALEI
245
IKGGALRQEE
255
VYYDSSRWTT
265
LLIRNPSRKI
275

LEELYSTSYN
285
WDRFI
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NDP or .NDP2 or .NDP3 or :3NDP;style chemicals stick;color identity;select .A:41 or .A:42 or .A:43 or .A:44 or .A:45 or .A:46 or .A:47 or .A:64 or .A:65 or .A:66 or .A:67 or .A:70 or .A:91 or .A:92 or .A:93 or .A:94 or .A:119 or .A:120 or .A:121 or .A:122 or .A:123 or .A:142 or .A:147 or .A:168 or .A:169 or .A:170 or .A:183 or .A:187 or .A:215 or .A:216 or .A:217 or .A:218 or .A:220 or .A:222 or .A:223; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
GLY41
3.246
ALA42
3.607
SER43
2.703
LYS44
3.282
GLY45
3.339
ILE46
2.773
GLY47
4.428
THR64
4.704
ALA65
3.377
ARG66
2.546
SER67
2.891
THR70
4.461
GLY91
3.800
THR92
3.368
MET93
2.973
GLU94
4.156
ASN119
2.623
HIS120
3.900
Residue
Distance (Å)
ILE121
3.164
THR122
4.220
ASN123
3.858
VAL142
3.973
TYR147
4.047
VAL168
3.535
SER169
3.314
SER170
3.401
TYR183
2.536
LYS187
2.961
LEU215
3.491
GLY216
3.313
LEU217
3.317
ILE218
3.013
THR220
2.970
THR222
2.679
ALA223
3.311
References  Top
REF 1 Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. J Biol Chem. 2005 Feb 11;280(6):4639-48.
REF 2 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11?-HSD1 inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4685-91.
REF 3 Discovery of SAR184841, a potent and long-lasting inhibitor of 11-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2414-21.
REF 4 Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11beta-hydroxysteroid-dehydrogenase type 1. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2244-51.
REF 5 The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61.
REF 6 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure an... J Med Chem. 2008 May 22;51(10):2933-43.
REF 7 Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
REF 8 Novel acidic 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47.

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