Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70176 | Target Info | |||
| Target Name | Cyclin-dependent kinase 2 (CDK2) | ||||
| Synonyms | Sin3 associated polypeptide; SIN3-associated protein; P33 protein kinase; Cell division protein kinase 2; CDKN2 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Trifluoromagnesate(1-) | Ligand Info | |||
| Canonical SMILES | [F-].[F-].[F-].[Mg+2] | ||||
| InChI | 1S/3FH.Mg/h3*1H;/q;;;+2/p-3 | ||||
| InChIKey | GJOMWUHGUQLOAC-UHFFFAOYSA-K | ||||
| PubChem Compound ID | 5496785 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3QHW Structure of a pCDK2/CyclinA transition-state mimic | ||||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | No | [1] |
| PDB Sequence |
GHMENFQKVE
8 KIGEGTYGVV18 YKARNKLTGE28 VVALKKIRLD38 TETEGVPSTA48 IREISLLKEL 58 NHPNIVKLLD68 VIHTENKLYL78 VFEFLHQDLK88 KFMDASALTG98 IPLPLIKSYL 108 FQLLQGLAFC118 HSHRVLHRDL128 KPQNLLINTE138 GAIKLADFGL148 ARAFGVPVRT 158 YHEVVTLWYR169 APEILLGCKY179 YSTAVDIWSL189 GCIFAEMVTR199 RALFPGDSEI 209 DQLFRIFRTL219 GTPDEVVWPG229 VTSMPDYKPS239 FPKWARQDFS249 KVVPPLDEDG 259 RSLLSQMLHY269 DPNKRISAKA279 ALAHPFFQDV289 TKPVPHL
|
|||||
|
|
||||||
| PDB ID: 3QHR Structure of a pCDK2/CyclinA transition-state mimic | ||||||
| Method | X-ray diffraction | Resolution | 2.17 Å | Mutation | No | [1] |
| PDB Sequence |
GHMENFQKVE
8 KIGEGTYGVV18 YKARNKLTGE28 VVALKKIRLD38 TETEGVPSTA48 IREISLLKEL 58 NHPNIVKLLD68 VIHTENKLYL78 VFEFLHQDLK88 KFMDASALTG98 IPLPLIKSYL 108 FQLLQGLAFC118 HSHRVLHRDL128 KPQNLLINTE138 GAIKLADFGL148 ARAFGVPVRT 158 YHEVVTLWYR169 APEILLGCKY179 YSTAVDIWSL189 GCIFAEMVTR199 RALFPGDSEI 209 DQLFRIFRTL219 GTPDEVVWPG229 VTSMPDYKPS239 FPKWARQDFS249 KVVPPLDEDG 259 RSLLSQMLHY269 DPNKRISAKA279 ALAHPFFQDV289 TKPVPHL
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis. Structure. 2011 May 11;19(5):675-90. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.