Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77393 | Target Info | |||
| Target Name | WD repeat-containing protein 5 (WDR5) | ||||
| Synonyms | BMP2-induced 3-kb gene protein; BIG3 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | WDR5 | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Serotonin | Ligand Info | |||
| Canonical SMILES | C1=CC2=C(C=C1O)C(=CN2)CCN | ||||
| InChI | 1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | ||||
| InChIKey | QZAYGJVTTNCVMB-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 5202 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7CFP Crystal structure of WDR5 in complex with a H3Q5ser peptide | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
VKPNYALKFT
40 LAGHTKAVSS50 VKFSPNGEWL60 ASSSADKLIK70 IWGAYDGKFE80 KTISGHKLGI 90 SDVAWSSDSN100 LLVSASDDKT110 LKIWDVSSGK120 CLKTLKGHSN130 YVFCCNFNPQ 140 SNLIVSGSFD150 ESVRIWDVKT160 GKCLKTLPAH170 SDPVSAVHFN180 RDGSLIVSSS 190 YDGLCRIWDT200 ASGQCLKTLI210 DDDNPPVSFV220 KFSPNGKYIL230 AATLDNTLKL 240 WDYSKGKCLK250 TYTGHKNEKY260 CIFANFSVTG270 GKWIVSGSED280 NLVYIWNLQT 290 KEIVQKLQGH300 TDVVISTACH310 PTENIIASAA320 LENDKTIKLW330 KSDC |
|||||
|
|
||||||
| PDB ID: 7CFQ Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
VKPNYALKFT
40 LAGHTKAVSS50 VKFSPNGEWL60 ASSSADKLIK70 IWGAYDGKFE80 KTISGHKLGI 90 SDVAWSSDSN100 LLVSASDDKT110 LKIWDVSSGK120 CLKTLKGHSN130 YVFCCNFNPQ 140 SNLIVSGSFD150 ESVRIWDVKT160 GKCLKTLPAH170 SDPVSAVHFN180 RDGSLIVSSS 190 YDGLCRIWDT200 ASGQCLKTLI210 DDDNPPVSFV220 KFSPNGKYIL230 AATLDNTLKL 240 WDYSKGKCLK250 TYTGHKNEKY260 CIFANFSVTG270 GKWIVSGSED280 NLVYIWNLQT 290 KEIVQKLQGH300 TDVVISTACH310 PTENIIASAA320 LENDKTIKLW330 KSDC |
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv. 2021 Jun 18;7(25):eabf4291. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.