Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T83369 Target Info
Target Name Coagulation factor IX (F9)
Synonyms Plasma thromboplastin component; PTC protein; Factor IX; Christmas factor
Target Type Successful Target
Gene Name F9
Biochemical Class Peptidase
UniProt ID
FA9_HUMAN
Ligand General Information  Top
Ligand Name Uridine-5'-Diphosphate Ligand Info
Canonical SMILES C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
InChI 1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKey XCCTYIAWTASOJW-XVFCMESISA-N
PubChem Compound ID 6031
Drug Binding Sites of Target  Top
PDB ID: 5F85      Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) and UDP
Method X-ray diffraction Resolution 2.15 Å Mutation No [1]
PDB Sequence
GDQCESNPCL
57
NGGSCKDDIN
67
SYECWCPFGF
77
EGKNCELLE
Residue
Distance (Å)
GLU52
4.868
Residue
Distance (Å)
PDB ID: 5F84      Crystal structure of Drosophila Poglut1 (Rumi) complexed with its glycoprotein product (glucosylated EGF repeat) and UDP
Method X-ray diffraction Resolution 2.50 Å Mutation No [1]
PDB Sequence
GDQCESNPCL
57
NGGSCKDDIN
67
SYECWCPFGF
77
EGKNCELLE
Residue
Distance (Å)
GLU52
4.924
Residue
Distance (Å)
References  Top
REF 1 Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat Chem Biol. 2016 Sep;12(9):735-40.

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