Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84631 | Target Info | |||
| Target Name | Coagulation factor Xa (F10) | ||||
| Synonyms | Fxa; Factor Xa; F10; Activated coagulation factor X | ||||
| Target Type | Successful Target | ||||
| Gene Name | F10 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | DL-threo-beta-hydroxyaspartate | Ligand Info | |||
| Canonical SMILES | C(C(C(=O)O)O)(C(=O)O)N | ||||
| InChI | 1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1 | ||||
| InChIKey | YYLQUHNPNCGKJQ-LWMBPPNESA-N | ||||
| PubChem Compound ID | 443239 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1XKA FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [1] |
| PDB Sequence |
QCETSPCQNQ
58 GKCKGLGEYT69 CTCLEGFEGK79 NCELFTRKLC89 SLDNGDCDQF99 CHEEQNSVVC 109 SCARGYTLAD119 NGKACIPTGP129 YPCGKQTLER139
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| PDB ID: 1XKB FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
DQCETSPCQN
57 QGKCKGLGEY68 TCTCLEGFEG78 KNCELFTRKL88 CSLDNGDCDQ98 FCHEEQNSVV 108 CSCARGYTLA118 DNGKACIPTG128 PYPCGKQTLE138
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis for chemical inhibition of human blood coagulation factor Xa. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6630-5. | ||||
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