Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T84631 Target Info
Target Name Coagulation factor Xa (F10)
Synonyms Fxa; Factor Xa; F10; Activated coagulation factor X
Target Type Successful Target
Gene Name F10
Biochemical Class Peptidase
UniProt ID
FA10_HUMAN
Ligand General Information  Top
Ligand Name 2-(carboxymethylamino)-2-oxoacetic acid Ligand Info
Canonical SMILES C(C(=O)O)NC(=O)C(=O)O
InChI 1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
InChIKey BIMZLRFONYSTPT-UHFFFAOYSA-N
PubChem Compound ID 3080614
Drug Binding Sites of Target  Top
PDB ID: 6Q9F      Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in complex with Mn, NOG and Factor X peptide fragment (39mer-4Ser)
Method X-ray diffraction Resolution 1.63 Å Mutation Yes [1]
PDB Sequence
NQGKCKDGLG
106
EYTCTSLEGF
116
Residue
Distance (Å)
ASP103
4.423
Residue
Distance (Å)
PDB ID: 5JQY      Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and factor X substrate peptide fragment(39mer-4Ser)
Method X-ray diffraction Resolution 1.99 Å Mutation Yes [2]
PDB Sequence
GKCKDGLGEY
108
TCTSLEGF
Residue
Distance (Å)
ASP103
3.203
Residue
Distance (Å)
PDB ID: 5JZ8      Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine, and factor X substrate peptide fragment (39mer)
Method X-ray diffraction Resolution 2.10 Å Mutation No [2]
PDB Sequence
GKCKDGLGEY
108
TCTCLEGF
Residue
Distance (Å)
ASP103
2.955
Residue
Distance (Å)
PDB ID: 5JZU      Aspartyl/Asparaginyl beta-hydroxylase (AspH)oxygenase and TPR domains in complex with manganese, N-oxalylglycine and factor X substrate peptide fragment (26mer)
Method X-ray diffraction Resolution 2.50 Å Mutation No [2]
PDB Sequence
GKCKDGLGEY
108
TCT
Click to Show 3D Structure of This Binding Site
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Residue
Distance (Å)
ASP103
3.179
Residue
Distance (Å)
References  Top
REF 1 Aspartyl/Asparaginyl beta-hydroxylase (AspH) H679A in complex with Mn, NOG and Factor X peptide fragment (39mer-4Ser)
REF 2 Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nat Commun. 2019 Oct 28;10(1):4910.

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