Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87109 | Target Info | |||
| Target Name | Casein kinase I delta (CSNK1D) | ||||
| Synonyms | Tau-protein kinase CSNK1D; HCKID; Casein kinase I isoform delta; CKId; CKI-delta | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | CSNK1D | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Adenosine monophosphate | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O)N | ||||
| InChI | 1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | UDMBCSSLTHHNCD-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 6083 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7P7G Crystal structure of phosphorylated pT220 Casein Kinase I delta (CK1d), conformation 2 and 3 | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [1] |
| PDB Sequence |
RYRLGRKIGS
17 GSFGDIYLGT27 DIAAGEEVAI37 KLECVKTKHP47 QLHIESKIYK57 MMQGGVGIPT 67 IRWCGAEGDY77 NVMVMELLGP87 SLEDLFNFCS97 RKFSLKTVLL107 LADQMISRIE 117 YIHSKNFIHR127 DVKPDNFLMG137 LGKKGNLVYI147 IDFGLAKKYR157 DARTHQHIPY 167 RENKNLTGTA177 RYASINTHLG187 IEQSRRDDLE197 SLGYVLMYFN207 LGSLPWQGLK 217 AAKRQKYERI228 SEKKMSTPIE238 VLCKGYPSEF248 ATYLNFCRSL258 RFDDKPDYSY 268 LRQLFRNLFH278 RQGFSYDYVF288 DWNMLK
|
|||||
|
|
||||||
| PDB ID: 7P7F Crystal structure of phosphorylated pT220 Casein Kinase I delta (CK1d), conformation 1 | ||||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [1] |
| PDB Sequence |
LRVGNRYRLG
12 RKIGSGSFGD22 IYLGTDIAAG32 EEVAIKLECV42 KTKHPQLHIE52 SKIYKMMQGG 62 VGIPTIRWCG72 AEGDYNVMVM82 ELLGPSLEDL92 FNFCSRKFSL102 KTVLLLADQM 112 ISRIEYIHSK122 NFIHRDVKPD132 NFLMGLGKKG142 NLVYIIDFGL152 AKKYRDARTH 162 QHIPYRENKN172 LTGTARYASI182 NTHLGIEQSR192 RDDLESLGYV202 LMYFNLGSLP 212 WQGLKAAKRQ223 KYERISEKKM233 STPIEVLCKG243 YPSEFATYLN253 FCRSLRFDDK 263 PDYSYLRQLF273 RNLFHRQGFS283 YDYVFDWNML293 K
|
|||||
|
|
ILE15
3.838
GLY16
3.771
SER17
4.185
GLY18
3.611
SER19
4.818
GLY21
3.863
ILE23
2.861
ALA36
3.640
LYS38
2.894
GLU52
4.733
PRO66
4.837
MET82
3.633
|
|||||
| PDB ID: 7P7H Crystal structure of Casein Kinase I delta (CK1d) with alphaG-in conformation | ||||||
| Method | X-ray diffraction | Resolution | 2.40 Å | Mutation | No | [1] |
| PDB Sequence |
LRVGNRYRLG
12 RKIGSGSFGD22 IYLGTDIAAG32 EEVAIKLECV42 KTKHPQLHIE52 SKIYKMMQGG 62 VGIPTIRWCG72 AEGDYNVMVM82 ELLGPSLEDL92 FNFCSRKFSL102 KTVLLLADQM 112 ISRIEYIHSK122 NFIHRDVKPD132 NFLMGLGKKG142 NLVYIIDFGL152 AKKYRDARTH 162 QHIPYRENKN172 LTGTARYASI182 NTHLGIEQSR192 RDDLESLGYV202 LMYFNLGSLP 212 WQGLKAATKR222 QKYERISEKK232 MSTPIEVLCK242 GYPSEFATYL252 NFCRSLRFDD 262 KPDYSYLRQL272 FRNLFHRQGF282 SYDYVFDWNM292 LK
|
|||||
|
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes. Mol Cell. 2022 Jun 2;82(11):2006-2020.e8. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.