Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T90167 Target Info
Target Name Polyubiquitin-C (UBC)
Synonyms ubiquitin C; HMG20
Target Type Patented-recorded Target
Gene Name UBC
UniProt ID
UBC_HUMAN
Ligand General Information  Top
Ligand Name Propylamine Ligand Info
Canonical SMILES CCCN
InChI 1S/C3H9N/c1-2-3-4/h2-4H2,1H3
InChIKey WGYKZJWCGVVSQN-UHFFFAOYSA-N
PubChem Compound ID 7852
Drug Binding Sites of Target  Top
PDB ID: 7MIC      Maize rayado fino virus protease in complex with Ubiquitin
Method X-ray diffraction Resolution 2.09 Å Mutation Yes [1]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Residue
Distance (Å)
ARG74
4.737
Residue
Distance (Å)
GLY75
1.400
PDB ID: 3BY4      Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin
Method X-ray diffraction Resolution 1.55 Å Mutation No [2]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Residue
Distance (Å)
ARG74
4.586
Residue
Distance (Å)
GLY75
1.337
PDB ID: 3C0R      Structure of Ovarian Tumor (OTU) domain in complex with Ubiquitin
Method X-ray diffraction Resolution 2.31 Å Mutation No [2]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Residue
Distance (Å)
ARG74
4.740
Residue
Distance (Å)
GLY75
1.338
PDB ID: 3PT2      Structure of a viral OTU domain protease bound to Ubiquitin
Method X-ray diffraction Resolution 2.50 Å Mutation No [3]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3CN or .3CN2 or .3CN3 or :33CN;style chemicals stick;color identity;select .B:74 or .B:75; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG74
4.803
Residue
Distance (Å)
GLY75
1.396
PDB ID: 4HXD      Diversity of ubiquitin and ISG15 specificity amongst nairoviruses viral ovarian tumor domain proteases
Method X-ray diffraction Resolution 2.85 Å Mutation No [4]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .3CN or .3CN2 or .3CN3 or :33CN;style chemicals stick;color identity;select .A:74 or .A:75; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
Residue
Distance (Å)
ARG74
4.961
Residue
Distance (Å)
GLY75
1.334
References  Top
REF 1 The endopeptidase of the maize-affecting Marafivirus type member maize rayado fino virus doubles as a deubiquitinase. J Biol Chem. 2021 Aug;297(2):100957.
REF 2 Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem. 2008 Apr 18;283(16):11038-49.
REF 3 Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2222-7.
REF 4 Diversity of ubiquitin and ISG15 specificity among nairoviruses' viral ovarian tumor domain proteases. J Virol. 2013 Apr;87(7):3815-27.

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