Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T90167 Target Info
Target Name Polyubiquitin-C (UBC)
Synonyms ubiquitin C; HMG20
Target Type Patented-recorded Target
Gene Name UBC
UniProt ID
UBC_HUMAN
Ligand General Information  Top
Ligand Name Selenomethionine Ligand Info
Canonical SMILES C[Se]CCC(C(=O)O)N
InChI 1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
InChIKey RJFAYQIBOAGBLC-UHFFFAOYSA-N
PubChem Compound ID 15103
Drug Binding Sites of Target  Top
PDB ID: 4I6N      Crystal structure of Trichinella spiralis UCH37 catalytic domain bound to Ubiquitin vinyl methyl ester
Method X-ray diffraction Resolution 1.70 Å Mutation No [1]
PDB Sequence
QIFVKTLTGK
11
TITLEVEPSD
21
TIENVKAKIQ
31
DKEGIPPDQQ
41
RLIFAGKQLE
51

DGRTLSDYNI
61
QKESTLHLVL
71
RLRG
Residue
Distance (Å)
GLN2
1.328
ILE3
3.935
LEU15
3.569
GLU16
2.629
VAL17
2.723
GLU18
4.500
Residue
Distance (Å)
PRO19
3.926
LEU56
4.337
ILE61
3.950
GLN62
3.808
LYS63
3.557
PDB ID: 2J7Q      Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate
Method X-ray diffraction Resolution 1.80 Å Mutation No [2]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Residue
Distance (Å)
LEU73
4.753
Residue
Distance (Å)
GLY75
4.235
References  Top
REF 1 Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity. Biochemistry. 2013 May 21;52(20):3564-78.
REF 2 Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell. 2007 Mar 9;25(5):677-87.

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