Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T90167 Target Info
Target Name Polyubiquitin-C (UBC)
Synonyms ubiquitin C; HMG20
Target Type Patented-recorded Target
Gene Name UBC
UniProt ID
UBC_HUMAN
Ligand General Information  Top
Ligand Name Ethylamine Ligand Info
Canonical SMILES CCN
InChI 1S/C2H7N/c1-2-3/h2-3H2,1H3
InChIKey QUSNBJAOOMFDIB-UHFFFAOYSA-N
PubChem Compound ID 6341
Drug Binding Sites of Target  Top
PDB ID: 4FJV      Crystal Structure of Human Otubain2 and Ubiquitin Complex
Method X-ray diffraction Resolution 2.05 Å Mutation No [1]
PDB Sequence
DVPDYAHMQI
3
FVKTLTGKTI
13
TLEVEPSDTI
23
ENVKAKIQDK
33
EGIPPDQQRL
43

IFAGKQLEDG
53
RTLSDYNIQK
63
ESTLHLVLRL
73
RG
Residue
Distance (Å)
ARG74
4.710
Residue
Distance (Å)
GLY75
1.338
PDB ID: 2IBI      Covalent Ubiquitin-USP2 Complex
Method X-ray diffraction Resolution 2.20 Å Mutation Yes [2]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Residue
Distance (Å)
ARG74
4.492
Residue
Distance (Å)
GLY75
1.271
PDB ID: 3IHP      Covalent Ubiquitin-Usp5 Complex
Method X-ray diffraction Resolution 2.80 Å Mutation No [3]
PDB Sequence
MQIFVKTLTG
10
KTITLEVEPS
20
DTIENVKAKI
30
QDKEGIPPDQ
40
QRLIFAGKQL
50

EDGRTLSDYN
60
IQKESTLHLV
70
LRLRG
Residue
Distance (Å)
ARG74
4.541
Residue
Distance (Å)
GLY75
1.262
References  Top
REF 1 The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages. PLoS One. 2015 Jan 15;10(1):e0115344.
REF 2 Covalent Ubiquitin-USP2 Complex
REF 3 Covalent Ubiquitin-Usp5 Complex

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.