Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92076 | Target Info | |||
| Target Name | Extracellular calcium-sensing receptor (CASR) | ||||
| Synonyms | hCasR; Parathyroid cell calciumreceptor; Parathyroid cell calcium-sensing receptor 1; Parathyroid calcium receptor; Parathyroid Cell calcium-sensing receptor; PCaR1; GPRC2A; CaSR | ||||
| Target Type | Successful Target | ||||
| Gene Name | CASR | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | NPS-2143 | Ligand Info | |||
| Canonical SMILES | CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O | ||||
| InChI | 1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1 | ||||
| InChIKey | PZUJQWHTIRWCID-HXUWFJFHSA-N | ||||
| PubChem Compound ID | 6918446 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7M3E Asymmetric Activation of the Calcium Sensing Receptor Homodimer | ||||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
YGPDQRAQKK
29 GDIILGGLFP39 IHFGVAAKDQ49 DLKSRPESVE59 CIRYNFRGFR69 WLQAMIFAIE 79 EINSSPALLP89 NLTLGYRIFD99 TCNTVSKALE109 ATLSFVAQNK119 IDSLNLDCSE 133 HIPSTIAVVG143 ATGSGVSTAV153 ANLLGLFYIP163 QVSYASSSRL173 LSNKNQFKSF 183 LRTIPNDEHQ193 ATAMADIIEY203 FRWNWVGTIA213 ADDDYGRPGI223 EKFREEAEER 233 DICIDFSELI243 SQYSDEEEIQ253 HVVEVIQNST263 AKVIVVFSSG273 PDLEPLIKEI 283 VRRNITGKIW293 LASEAWASSS303 LIAMPQYFHV313 VGGTIGFALK323 AGQIPGFREF 333 LKKVHPRKSV343 HNGFAKEFWE353 ETFNCHLQFR392 PLCTGDENIS402 SVETPYIDYT 412 HLRISYNVYL422 AVYSIAHALQ432 DIYTCLPGRG442 LFTNGSCADI452 KKVEAWQVLK 462 HLRHLNFTNN472 MGEQVTFDEC482 GDLVGNYSII492 NWHLSPEDGS502 IVFKEVGYYN 512 VYAKKGERLF522 INEEKILWSG532 FSREVPFSNC542 SRDCLAGTRK552 GIIEGEPTCC 562 FECVECPDGE572 YSDETDASAC582 NKCPDDFWSN592 ENHTSCIAKE602 IEFLSWTEPF 612 GIALTLFAVL622 GIFLTAFVLG632 VFIKFRNTPI642 VKATNRELSY652 LLLFSLLCCF 662 SSSLFFIGEP672 QDWTCRLRQP682 AFGISFVLCI692 SCILVKTNRV702 LLVFLNLQFL 726 LVFLCTFMQI736 VICVIWLYTA746 PPSSYRNQEL756 EDEIIFITCH766 EGSLMALGFL 776 IGYTCLLAAI786 CFFFAFKSRK796 LPENFNEAKF806 ITFSMLIFFI816 VWISFIPAYA 826 STYGKFVSAV836 EVIAILAASF846 GLLACIFFNK856 IYIILFKPSR866 NTIEEVRCST 876
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| PDB ID: 7M3J Asymmetric Activation of the Calcium Sensing Receptor Homodimer | ||||||
| Method | Electron microscopy | Resolution | 4.10 Å | Mutation | No | [1] |
| PDB Sequence |
QRAQKKGDII
33 LGGLFPIHFG43 VAAKDQDLKS53 RPESVECIRY63 NFRGFRWLQA73 MIFAIEEINS 83 SPALLPNLTL93 GYRIFDTCNT103 VSKALEATLS113 FVAQNKIPST138 IAVVGATGSG 148 VSTAVANLLG158 LFYIPQVSYA168 SSSRLLSNKN178 QFKSFLRTIP188 NDEHQATAMA 198 DIIEYFRWNW208 VGTIAADDDY218 GRPGIEKFRE228 EAEERDICID238 FSELISQYSD 248 EEEIQHVVEV258 IQNSTAKVIV268 VFSSGPDLEP278 LIKEIVRRNI288 TGKIWLASEA 298 WASSSLIAMP308 QYFHVVGGTI318 GFALKAGQIP328 GFREFLKKVH338 PRKSVHNGFA 348 KEFWEETFNI401 SSVETPYIDY411 THLRISYNVY421 LAVYSIAHAL431 QDIYTCLPGR 441 GLFTNGSCAD451 IKKVEAWQVL461 KHLRHLNFTN471 NMGEQVTFDE481 CGDLVGNYSI 491 INWHLSPEDG501 SIVFKEVGYY511 NVYAKKGERL521 FINEEKILWS531 GFSREVPFSN 541 CSRDCLAGTR551 KGIIEGEPTC561 CFECVECPDG571 EYSDETDASA581 CNKCPDDFWS 591 NENHTSCIAK601 EIEFLSWTEP611 FGIALTLFAV621 LGIFLTAFVL631 GVFIKFRNTP 641 IVKATNRELS651 YLLLFSLLCC661 FSSSLFFIGE671 PQDWTCRLRQ681 PAFGISFVLC 691 ISCILVKTNR701 VLLLNLQFLL727 VFLCTFMQIV737 ICVIWLYTAP747 PSSYRNQELE 757 DEIIFITCHE767 GSLMALGFLI777 GYTCLLAAIC787 FFFAFKSRKL797 PENFNEAKFI 807 TFSMLIFFIV817 WISFIPAYAS827 TYGKFVSAVE837 VIAILAASFG847 LLACIFFNKI 857 YIILFKPSRN867 TIEEVRC
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Asymmetric activation of the calcium-sensing receptor homodimer. Nature. 2021 Jul;595(7867):455-459. | ||||
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