Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T98089 | Target Info | |||
| Target Name | Deoxycytidine kinase (DCK) | ||||
| Synonyms | dCK | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | DCK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | adenosine diphosphate | Ligand Info | |||
| Canonical SMILES | C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N | ||||
| InChI | 1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||
| InChIKey | XTWYTFMLZFPYCI-KQYNXXCUSA-N | ||||
| PubChem Compound ID | 6022 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 1P5Z Structure of human dCK complexed with cytarabine and ADP-MG | ||||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [1] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLCEDWE49 VVPEPVARWC59 NVQSTNGGNV81 LQMMYEKPER 91 WSFTFQTYAC101 LSRIRAQLAS111 LNGKLKDAEK121 PVLFFERSVY131 SDRYIFASNL 141 YESECMNETE151 WTIYQDWHDW161 MNNQFGQSLE171 LDGIIYLQAT181 PETCLHRIYL 191 RGRNEEQGIP201 LEYLEKLHYK211 HESWLLHRTL221 KTNFDYLQEV231 PILTLDVNED 241 FKDKYESLVE251 KVKEFLSTL
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| PDB ID: 1P62 Structure of human dCK complexed with gemcitabine and ADP-MG | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [1] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLCEDWE49 VVPEPVARWC59 NVQSTNGGNV81 LQMMYEKPER 91 WSFTFQTYAC101 LSRIRAQLAS111 LNGKLKDAEK121 PVLFFERSVY131 SDRYIFASNL 141 YESECMNETE151 WTIYQDWHDW161 MNNQFGQSLE171 LDGIIYLQAT181 PETCLHRIYL 191 RGRNEEQGIP201 LEYLEKLHYK211 HESWLLHRTL221 KTNFDYLQEV231 PILTLDVNED 241 FKDKYESLVE251 KVKEFLSTL
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| PDB ID: 1P60 Structure of human dCK complexed with 2'-Deoxycytidine and ADP, Space group C 2 2 21 | ||||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | No | [1] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLCEDW48 EVVPEPVARW58 CNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESECMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYES248 LVEKVKEFLS258 TL
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| PDB ID: 1P61 Structure of human dCK complexed with 2'-Deoxycytidine and ADP, P 43 21 2 space group | ||||||
| Method | X-ray diffraction | Resolution | 2.21 Å | Mutation | No | [1] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLCEDWE49 VVPEPVARWC59 NVQSTNGGNV81 LQMMYEKPER 91 WSFTFQTYAC101 LSRIRAQLAS111 LNGKLKDAEK121 PVLFFERSVY131 SDRYIFASNL 141 YESECMNETE151 WTIYQDWHDW161 MNNQFGQSLE171 LDGIIYLQAT181 PETCLHRIYL 191 RGRNEEQGIP201 LEYLEKLHYK211 HESWLLHRTL221 KTNFDYLQEV231 PILTLDVNED 241 FKDKYESLVE251 KVKEFLSTL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .B:29 or .B:30 or .B:31 or .B:32 or .B:33 or .B:34 or .B:35 or .B:36 or .B:127 or .B:188 or .B:191 or .B:192 or .B:194 or .B:238 or .B:240 or .B:241 or .B:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2A7Q Crystal structure of human dCK complexed with clofarabine and ADP | ||||||
| Method | X-ray diffraction | Resolution | 2.55 Å | Mutation | No | [2] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLCEDWE49 VVPEPVARWC59 NVQSTNGGNV81 LQMMYEKPER 91 WSFTFQTYAC101 LSRIRAQLAS111 LNGKLKDAEK121 PVLFFERSVY131 SDRYIFASNL 141 YESECMNETE151 WTIYQDWHDW161 MNNQFGQSLE171 LDGIIYLQAT181 PETCLHRIYL 191 RGRNEEQGIP201 LEYLEKLHYK211 HESWLLHRTL221 KTNFDYLQEV231 PILTLDVNED 241 FKDKYESLVE251 KVKEFLSTL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3KFX Human dCK complex with 5-Me dC and ADP | ||||||
| Method | X-ray diffraction | Resolution | 1.96 Å | Mutation | Yes | [3] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTNGGN80 VLQMMYEKPE 90 RWSFTFQTYA100 CLSRIRAQLA110 SLNGKLKDAE120 KPVLFFERSV130 YSDRYIFASN 140 LYESESMNET150 EWTIYQDWHD160 WMNNQFGQSL170 ELDGIIYLQA180 TPETCLHRIY 190 LRGRNEEQGI200 PLEYLEKLHY210 KHESWLLHRT220 LKTNFDYLQE230 VPILTLDVNE 240 DFKDKYESLV250 EKVKEFLSTL260
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:37 or .A:188 or .A:191 or .A:192 or .A:238 or .A:240 or .A:241 or .A:242 or .A:246; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 3IPX X-Ray structure of Human Deoxycytidine Kinase in complex with ADP and an inhibitor | ||||||
| Method | X-ray diffraction | Resolution | 2.00 Å | Mutation | No | [4] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLCEDWE49 VVPEPVARWC59 NVQSTNGGNV81 LQMMYEKPER 91 WSFTFQTYAC101 LSRIRAQLAS111 LNGKLKDAEK121 PVLFFERSVY131 SDRYIFASNL 141 YESECMNETE151 WTIYQDWHDW161 MNNQFGQSLE171 LDGIIYLQAT181 PETCLHRIYL 191 RGRNEEQGIP201 LEYLEKLHYK211 HESWLLHRTL221 KTNFDYLQEV231 PILTLDVNED 241 FKDKYESLVE251 KVKEFLSTL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2ZI4 C4S dCK variant of dCK in complex with L-dA+ADP | ||||||
| Method | X-ray diffraction | Resolution | 2.10 Å | Mutation | Yes | [5] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLSEDWE49 VVPEPVARWS59 NVQSNGGNVL82 QMMYEKPERW 92 SFTFQTYACL102 SRIRAQLASL112 NGKLKDAEKP122 VLFFERSVYS132 DRYIFASNLY 142 ESESMNETEW152 TIYQDWHDWM162 NNQFGQSLEL172 DGIIYLQATP182 ETCLHRIYLR 192 GRNEEQGIPL202 EYLEKLHYKH212 ESWLLHRTLK222 TNFDYLQEVP232 ILTLDVNEDF 242 KDKYESLVEK252 VKEFLSTL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2ZI3 C4S-E247A dCK variant of dCK in complex with D-dA+ADP | ||||||
| Method | X-ray diffraction | Resolution | 2.30 Å | Mutation | Yes | [5] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLSEDWE49 VVPEPVARWS59 NVQSTQDEFE69 ELTMSQKNGG 79 NVLQMMYEKP89 ERWSFTFQTY99 ACLSRIRAQL109 ASLNGKLKDA119 EKPVLFFERS 129 VYSDRYIFAS139 NLYESESMNE149 TEWTIYQDWH159 DWMNNQFGQS169 LELDGIIYLQ 179 ATPETCLHRI189 YLRGRNEEQG199 IPLEYLEKLH209 YKHESWLLHR219 TLKTNFDYLQ 229 EVPILTLDVN239 EDFKDKYASL249 VEKVKEFLST259 L
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2ZI9 C4S-E247A dCK variant of dCK in complex with cladribine+ADP | ||||||
| Method | X-ray diffraction | Resolution | 2.51 Å | Mutation | Yes | [6] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYAS248 LVEKVKEFLS258 TL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:28 or .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:37 or .A:127 or .A:128 or .A:188 or .A:191 or .A:192 or .A:238 or .A:240 or .A:241 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2NO7 C4S dCK variant of dCK in complex with L-dC+ADP | ||||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | Yes | [7] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYES248 LVEKVKEFLS258 TL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2NO0 C4S dCK variant of dCK in complex with gemcitabine+ADP | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [7] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYES248 LVEKVKEFLS258 TL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:37 or .A:188 or .A:191 or .A:192 or .A:238 or .A:240 or .A:241 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2NOA The structure of deoxycytidine kinase complexed with lamivudine and ADP. | ||||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | Yes | [8] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYES248 LVEKVKEFLS258 TL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:37 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2NO6 C4S dCK variant of dCK in complex with FTC+ADP | ||||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | Yes | [7] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYES248 LVEKVKEFLS258 TL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:37 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 2NO1 C4S dCK variant of dCK in complex with D-dC+ADP | ||||||
| Method | X-ray diffraction | Resolution | 1.91 Å | Mutation | Yes | [7] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFSL170 ELDGIIYLQA 180 TPETCLHRIY190 LRGRNEEQGI200 PLEYLEKLHY210 KHESWLLHRT220 LKTNFDYLQE 230 VPILTLDVNE240 DFKDKYESLV250 EKVKEFLSTL260
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 2NO9 The structure of deoxycytidine kinase complexed with troxacitabine and ADP. | ||||||
| Method | X-ray diffraction | Resolution | 2.15 Å | Mutation | Yes | [8] |
| PDB Sequence |
TRIKKISIEG
28 NIAAGKSTFV38 NILKQLSEDW48 EVVPEPVARW58 SNVQSTQDEF68 EELTMSQKNG 78 GNVLQMMYEK88 PERWSFTFQT98 YACLSRIRAQ108 LASLNGKLKD118 AEKPVLFFER 128 SVYSDRYIFA138 SNLYESESMN148 ETEWTIYQDW158 HDWMNNQFGQ168 SLELDGIIYL 178 QATPETCLHR188 IYLRGRNEEQ198 GIPLEYLEKL208 HYKHESWLLH218 RTLKTNFDYL 228 QEVPILTLDV238 NEDFKDKYES248 LVEKVKEFLS258 TL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:37 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
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| PDB ID: 3HP1 Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP | ||||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | Yes | [9] |
| PDB Sequence |
RIKKISIEGN
29 IAAGKSTFVN39 ILKQLCEDWE49 VVPEPVARWC59 NVQGGNVLQM84 MYEKPERWSF 94 TFQTYACLSM104 IRAQLASLNG114 KLKDAEKPVL124 FFERSVYSAR134 YIFASNLYES 144 ECMNETEWTI154 YQDWHDWMNN164 QFGQSLELDG174 IIYLQATPET184 CLHRIYLRGR 194 NEEQGIPLEY204 LEKLHYKHES214 WLLHRTLKTN224 FDYLQEVPIL234 TLDVNEDFKD 244 KYESLVEKVK254 EFLSTL
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .ADP or .ADP2 or .ADP3 or :3ADP;style chemicals stick;color identity;select .A:29 or .A:30 or .A:31 or .A:32 or .A:33 or .A:34 or .A:35 or .A:36 or .A:127 or .A:188 or .A:191 or .A:192 or .A:194 or .A:238 or .A:240 or .A:241 or .A:242; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. Nat Struct Biol. 2003 Jul;10(7):513-9. | ||||
| REF 2 | The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):133-9. | ||||
| REF 3 | Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues. Biochemistry. 2010 Aug 10;49(31):6784-90. | ||||
| REF 4 | Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6784-7. | ||||
| REF 5 | Structural basis for substrate promiscuity of dCK. J Mol Biol. 2008 May 2;378(3):607-21. | ||||
| REF 6 | Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase. J Med Chem. 2008 Jul 24;51(14):4219-25. | ||||
| REF 7 | Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides. J Med Chem. 2007 Jun 28;50(13):3004-14. | ||||
| REF 8 | Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Res. 2007;35(1):186-92. | ||||
| REF 9 | Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. Biochemistry. 2009 Feb 17;48(6):1256-63. | ||||
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