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| Target General Information |
Top |
| Target ID |
T78356 |
Target Info
|
| Target Name |
Thromboxane-A synthase (TBXAS1) |
| Synonyms |
Thromboxane A2 synthase; TXS; TXA synthase; Cytochrome P450 5A1; CYP5A1; CYP5 |
| Target Type |
Clinical trial Target |
| Gene Name |
TBXAS1 |
| Biochemical Class |
Intramolecular oxidoreductase |
| UniProt ID |
|
| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-34b-3p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
caaucacuaacuccacugccau
|
| miRNA Species |
Homo sapiens |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| 2 |
qRT-PCR |
[2] |
| Representative Target(s) Regulated by This miRNA |
Apoptosis regulator Bcl-2 (BCL-2)
|
Target Info
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|
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Cyclic AMP-responsive element-binding protein (CREB1)
|
Target Info
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| References |
Top |
| REF 1 |
Thromboxane A2 receptor promotes tumor growth through an autoregulatory feedback pathway. J Mol Cell Biol. 2013 Dec;5(6):380-90.
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| REF 2 |
miR-34b-3p May Promote Antiplatelet Efficiency of Aspirin by Inhibiting Thromboxane Synthase Expression. Thromb Haemost. 2019 Sep;119(9):1451-1460.
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