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| Target General Information |
Top |
| Target ID |
T81735 |
Target Info
|
| Target Name |
DNA-dependent protein kinase catalytic (PRKDC) |
| Synonyms |
p460; HYRC1; HYRC; DNPK1; DNA-dependent protein kinase catalytic subunit; DNA-PKcs; DNA-PK catalytic subunit |
| Target Type |
Clinical trial Target |
| Gene Name |
PRKDC |
| Biochemical Class |
Kinase |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
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| miRNA Mature ID |
hsa-miR-101-5p |
miRNA Info
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| miRNA Mature AC |
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| Sequence |
caguuaucacagugcugaugcu
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| miRNA Species |
Homo sapiens |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Luciferase Reporter Assay |
[1] |
| 2 |
Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
ATM serine/threonine kinase (ATM)
|
Target Info
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|
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DNA-dependent protein kinase catalytic (PRKDC)
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Target Info
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| References |
Top |
| REF 1 |
Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation. PLoS One. 2010 Jul 1;5(7):e11397.
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| REF 2 |
micorRNA-101 silences DNA-PKcs and sensitizes pancreatic cancer cells to gemcitabine. Biochem Biophys Res Commun. 2017 Jan 29;483(1):725-731.
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